23
4
7
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4170 | PKM2-IN-1 | PKM2 inhibitor,compound 3k | PKM |
PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. | |||
T67900 | PKM2 inhibitor G | PKM | |
PKM2 inhibitor G is a inhibitor of pyruvate kinase. | |||
T39984 | PKM2-IN-3 | PKM2-IN-3 | |
PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC 50 value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect. | |||
T62758 | PKM2 activator 2 | PKM | |
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol... | |||
T61504 | PKM2 activator 3 | ||
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is part... | |||
T81446 | PKM2 activator 6 | ||
Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM, respectively. It promotes apoptosis in colorectal cells while suppress... | |||
T72692 | PKM2 activator 4 | ||
PKM2 Activator 4, a chemical compound, functions as an activator of PKM2 with an activation concentration (AC 50) ranging from 1 to 10 μM. It is primarily utilized in cancer research. | |||
T79636 | PKM2-IN-4 | ||
Compound 5C, referred to as Pkm2-in-4, is a selective PKM2 inhibitor (IC50 = 0.35 µM) that modulates pyruvate-dependent respiration and promotes mitochondrial H2O2 production rate and electron transport system coupling [... | |||
T72693 | PKM2 activator 5 | PKM | |
PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases. | |||
T71867 | PKM2 inhibitor 2825-0090 | ||
PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo. | |||
T74814 | PKM2/PDK1-IN-1 | ||
PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS producti... | |||
T4223 | Mitapivat | PKR-IN-1 | PKM |
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency. | |||
T6816 | DASA-58 | PKM | |
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. | |||
T7214 | TEPP-46 | ML265 | PKM |
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. . | |||
T60102L | Dimethylaminomicheliolide HCl | PKM | |
Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations. | |||
T15362 | FX-11 | LDHA Inhibitor FX11 | Dehydrogenase |
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce... | |||
T68986 | ZINC08383544 | ||
ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor. | |||
T70665 | PF-06284674 | ||
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator. | |||
T75362 | TEPC466 | ||
TEPC466, a novel TEPP-46-based aggregation-induced emission (AIE) probe, exhibits high selectivity and sensitivity for PKM2 protein detection through the AIE effect. Demonstrating low toxicity, TEPC466 has been effective... | |||
T75317 | Vitamin K5 | ||
Vitamin K5 (Synkamin), a photosensitizer and antimicrobial agent, serves as a specific PKM2 inhibitor, demonstrating IC 50 values of 28, 191, and 120 μM against PKM2, PKM1, and PKL, respectively. It induces apoptosis in ... | |||
T77775 | TP-1454 | ||
TP-1454 is an activator against PKM2 with a biochemically determined AC50 of 10 Nm. It can regulate tumor immune responses by acting on T regulatory cells. | |||
T79602 | MTP | Autophagy | |
MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation. Further, it inhibits JAK2 signaling, rendering it useful for the study of ora... | |||
T79637 | CIAC001 | ||
CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically acti... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3376 | Cynaroside | Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside | Others , Influenza Virus , DNA/RNA Synthesis |
Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation. | |||
T1125 | Shikonin | NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid | TNF , NF-κB , Chloride channel , HIV Protease , PKM |
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities. | |||
T16837 | SAICAR | Others | |
T60581 | Alkannin | ||
Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1]. |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-04766 | PKM2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
PKM2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is P52480-2. | |||
TMPY-04465 | PKM2 Protein, Human, Recombinant (His) | Human | E. coli |
PKM2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 59 kDa and the accession number is P14618-1. | |||
TMPH-03362 | PKM2 Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus Insect Cells |
PKM2 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 61.8 kDa and the accession number is P11980. | |||
TMPH-02871 | PKM2 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells |
PKM2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 61.8 kDa and the accession number is P52480. | |||
TMPH-02872 | PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli |
PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.8 kDa and the accession number is P52480. | |||
TMPH-03363 | PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) | Rat | E. coli |
PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.8 kDa and the accession number is P11980. | |||
TMPY-04387 | AKT2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer prog... |