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T0082 |
Domperidone
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R33812 |
Dopamine Receptor
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Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger z... |
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T24115 |
GSK854
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GSK-854,GSK 854 |
Apoptosis
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GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,... |
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T8669 |
3,3',4,4'-Benzophenonetetracarboxylic dianhydride
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Others
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3,3',4,4'-Benzophenonetetracarboxylic dianhydride is a compound used as a polyimide precursor in the production of polyimide films and adhesives. It is a non-toxic material with no known adverse effects on human health. |
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T0514 |
Phenindione
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Rectadione,phenylindandione,Phenylindione |
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Phenindione (Rectadione) is an indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. |
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T13730 |
Hydroxocobalamin acetate
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Others
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Hydroxocobalamin acetate is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia. Hydroxocobalamin, an injectable naturally occurring form of vitamin B12 with a favorable ad... |
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T1787 |
Levobupivacaine
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Sodium Channel
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Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... |
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T32161 |
Indoxyl sulfate
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Indoxyl sulfate is a metabolite of tryptophan, showing adverse effects on bones and the central nervous system, having been most frequently implicated as a contributor to renal disease progression and vascular disease |
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T36879 |
L-Leucyl-L-Leucine methyl ester hydrobromide
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The lysosomotropic dipeptide LLME has selective toxicity for NK cells, CTL, and M phi without adverse effects on a variety of other lymphoid or nonlymphoid cell types. See also E-2080. |
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T40932 |
Benzylacyclouridine
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5-Benzylacyclouridine,BAU |
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Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (... |
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T33583 |
Naldemedine
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S-297995,S297995,Naldemedine,S 297995,S297,995,S 297,995,S297,995;Naldemedine,S-297,995 |
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Naldemedine (S 297995) is a peripheral selective μ-opioid receptor antagonist being developed by Shionogi for the treatment of opioid-induced adverse reactions, including constipation, nausea, and vomiting. They are usua... |
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T68735 |
Ciclotropium (free base)
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Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing... |
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T62722 |
SC13
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SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects. |
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T16377 |
Odiparcil
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SB-424323 |
Thrombin
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Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antit... |
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T61344 |
VO-OHPic
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VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in mod... |
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T70362 |
V11294A
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V11294A is a novel PDE4 inhibitor. A single oral 300 mg dose of V11294A administered to healthy volunteers results in plasma concentrations adequate to inhibit activation of inflammatory cells ex vivo, which persists fo... |
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T70433 |
Antalarmin
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Antalarmin is a CRF-1 antagonist. By blocking CRF-1 activity the release of ACTH is reduced, and chronic stress is decreased in response to chronic stress. Antalarmin could be useful in reducing the adverse health conseq... |
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T60771 |
Metamizol
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Metamizol (Methamizole) blocks thyroid hormone production from the thyroid gland which is an anti-thyroid agent. However, Metamizol has hepatotoxicity as adverse effect [1]. |
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T73441 |
TBI-166
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TBI-166, an orally active riminophenazine analogue, serves as an anti-tuberculosis agent and exhibits fewer adverse reactions compared to its lead compound, Clofazimine [1] [2] [3]. |
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T69780 |
VU6007477
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VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp,uu = 0.32;... |
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T73091 |
NBI-921352
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XEN901 |
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NBI-921352 (XEN901) is a potent sodium channel inhibitor, specifically targeting Na_v1.6 channels. It effectively treats epilepsy-related nervous system pathologies without causing adverse side effects. |
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T78933 |
BD-9136
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Epigenetic Reader Domain
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BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential for cancer research [1]. |
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T70000 |
Ebopiprant HCl
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Ebopiprant, also known as OBE-022, is an Oral and Selective Prostaglandin F 2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. OBE022 exhibits potent tocolytic effects on human ... |
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T62254 |
TLR9-IN-1
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TLR9-IN-1 is a selective and potent TLR9 inhibitor that acts on human TLR9 (IC50: 7 nM). TLR9-IN-1 can be used in the study of adverse immune response-related diseases. |
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T69970 |
AZD5718
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AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Precl... |
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T75328 |
Hydroxocobalamin hydrochloride
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Hydroxocobalamin hydrochloride, a naturally occurring injectable form of vitamin B12, exhibits a favorable adverse effect profile. It is utilized as a dietary supplement for the study of vitamin B12 deficiency, including... |
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T63514 |
PPARγ agonist 1
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PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects. pparγ agonist 1 has shown research potential in cardiovascular diseases assoc... |
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T14493 |
Balapiravir
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R1626,Ro 4588161 |
Others
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Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safe... |
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T74364 |
SDOX
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Topoisomerase
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SDOX, a Doxorubicin (DOX) prodrug, selectively releases the active agent, DOX, in tumor cells with elevated glutathione (GSH) levels, thereby reducing inadvertent adverse effects on healthy tissues while maintaining ther... |
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T65440 |
Sodium Thiosulfate Pentahydrate
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Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3... |
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T61751 |
DNA-PK-IN-3
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DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tum... |
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T61976 |
DS-6930
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DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM. DS-6930 can effectively reduce plasma glucose (PG) level, and has less PPARγ-related adverse effects compared with Rosiglitazone. DS-6930 has researc... |
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T69119 |
Disopyramide HCl
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Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agen... |
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T69129 |
Clozapine HCl
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Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serot... |
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T70446 |
Abivertinib HCl
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Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell p... |
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T76468 |
Cecropin A (1-7)-Melittin A (2-9)
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Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide that exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative aerobic bacteria, in addition to antimalarial properties. Not... |
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T68324 |
KCN1
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KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF repo... |
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T72406 |
Tofacitinib Prodrug-1
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Tofacitinib Prodrug-1 is an effective and oral active prodrug to mitigate the systemic adverse effects of Tofacitinib. Tofacitinib Prodrug-1 can effectively attenuate the oxazolone-induced colitis in mice model with low ... |
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T37464 |
CAY10711
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CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displa... |
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T68330 |
Cerlapirdine hydrochloride
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Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of... |
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T64204 |
NU5455
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NU5455 is a selective, potent, orally active inhibitor of DNA-PKcs. NU5455 enhances the efficacy of locally released doxorubicin in liver tumour xenografts without causing any adverse effects. nU5455 enhances the efficac... |
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T71955 |
C3001a
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C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous sy... |
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T83121 |
Anatumomab mafenatox
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ABR-214936 |
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Anatumomab mafenatox (ABR-214936), a 73 KDa recombinant protein, targets the tumor-associated antigen 5T4 commonly expressed in malignancies. It is a conjugate comprising a modified form of SEA linked to a murine Fab. Th... |
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T9669 |
EST73502 hydrochloride
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EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respecti... |
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T73255 |
Akt1-IN-1
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Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenici... |
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T63545 |
FAK-IN-3
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FAK-IN-3 is a potent inhibitor of adherens spot kinase (FAK). FAK-IN-3 reduces migration and invasion of PA-1 cells and inhibits the expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis with no si... |
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T80789 |
WAY-639872
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WAY-639872 is an active molecule exhibiting (in vivo) efficacy. This compound selectively targets (enzyme X), demonstrating inhibition with an IC50 of 2 nM. Importantly, it possesses a (high level) of specificity, showin... |
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T71119 |
Netarsudil free base
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Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Hum... |
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T76020 |
AUNP-12 TFA
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AUNP-12 TFA (NP-12 TFA), a peptide antagonist of the PD-1 signaling pathway, exhibits equipotent antagonism toward PD-L1 and PD-L2, enhancing lymphocyte proliferation and effector functions. It promotes immune activation... |
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T81932 |
LIN28-IN-1
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LIN28-IN-1 (compound 5) is a selective inhibitor targeting the RNA-binding protein LIN28, specifically binding to its cold shock domain (CSD). This compound robustly interrupts the LIN28-let-7 miRNA interaction with an I... |
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T70070 |
Cisapride tartrate
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Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisa... |
