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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T25402 | Fagaramide | AI330755,AI3 30755,AI3-30755 | |
Fagaramide possesses Antiplasmodial activity. | |||
T14656 | Bis-propargyl-PEG3 | Others | |
Bis-propargyl-PEG3 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs. It is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (ZnDPA) complexes[1] [2]. | |||
T71289 | 9-O-Demethyltrigonostemone | ||
9-O-Demethyltrigonostemone is a natural IDO1 inhibitor, cytotoxic and antiplasmodial agent from the Roots of Strophioblachia fimbricalyx. | |||
T116970 | TLC3407-3786 | ||
MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity ... | |||
T75640 | Thalifendine chloride | ||
Thalifendine chloride, a Berberine metabolite, exhibits antiplasmodial and antiamoebic properties. It effectively inhibits P. falciparum and E. histolytica, with IC50 values of 7.91 μM and 116 μM, respectively [1] [2]. | |||
T75536 | Koshidacin B | ||
Koshidacin B, a cyclic tetrapeptide, exhibits potent antiplasmodial activity, evidenced by its ability to inhibit Plasmodium falciparum strains FCR3 and K1 with IC50 values of 0.89 μM and 0.83 μM, respectively. It has be... | |||
T79460 | Antimalarial agent 28 | Parasite | |
Antimalarial agent 28 (Compound 2i) acts as an antiplasmodial agent, exhibiting inhibition of P. berghei with IC50 values of 0.561 μM for the liver stage, 0.14 μM for early gametocytes, and 4.34 μM for the ring stages of... | |||
T60998 | Anticancer agent 75 | ||
Anticancer agent 75 has good antiplasmodial activity. Anticancer agent 75 is a potent anticancer agent with cytotoxicity and selectivity in cancer cell lines. The cytotoxicity of Anticancer agent 75 to normal human kidne... | |||
T83044 | Antimalarial agent 33 | Parasite | |
Antimalarial agent 33 (compound 5g) exhibits antiplasmodial activity targeting both erythrocytic and hepatic stages of Plasmodium, with an effective concentration (EC50) of 1.1 μM against the K1 strain of P. falciparum. ... | |||
T9763 | MMV666810 | ||
MMV666810, a 2-aminopyrazine analogue of MMV390048, exhibits potent antiplasmodial activity against asexual parasites with an IC50 value of 5.94 nM. It demonstrates enhanced efficacy against late-stage gametocytes with a... | |||
T35757 | Beauvericin A | ||
Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated fromB. bassianathat has diverse biological activities.1,2,3It is active againstM. tuberculosis(MIC = 25 μg/ml) andP. falciparum(IC50=... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1610 | Epimagnolin A | Parasite | |
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. | |||
TN3466 | Atherosperminine | cAMP , Calcium Channel , AChR , Parasite | |
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t... | |||
TN2239 | Strictosamide | ATPase , Potassium Channel , Sodium Channel , Parasite , Antifungal | |
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain. | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
T8206 | Cycleanine | Others | |
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. | |||
T11811 | Laetanine | Parasite | |
Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta. | |||
T3832 | 11-O-Galloylbergenin | Antioxidant , Immunology/Inflammation related | |
11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities. | |||
TL0013 | Heraclenin | Anti-infection , Immunology/Inflammation related | |
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Her... | |||
T3682 | (-)-Catechin gallate | (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate | Others , COX |
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat... | |||
T2S1635 | 3-Isomangostin | MTH1 | |
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac... | |||
T37345 | 5,7-Dihydroxycoumarin | Antibacterial | |
5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic... | |||
TN5327 | 11(13)-Dehydroivaxillin | ||
11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy. | |||
TN2380 | Glycerol 1-(26-hydroxyhexacosanoate) | Others | |
Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial | |||
TN2418 | Cassiachromone | Others | |
Cassiachromone has antiplasmodial activity | |||
T11681 | Isochondrodendrine | Isochondrodendrin | Others |
Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. | |||
TN2413 | Diacetylpiptocarphol | Others | |
Diacetylpiptocarphol has antiplasmodial activity | |||
TN3456 | Artoheterophyllin B | Antifection | |
Artoheterophyllin B has antiplasmodial activity. | |||
TN4218 | Homaloside D | Antifection | |
Homaloside D has antiplasmodial activity. | |||
TN2650 | 16-Oxocleroda-3,13E-dien-15-oic acid | Antifection | |
16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity. | |||
TN5657 | Goniotriol | ||
Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity a... | |||
TN4387 | Khellactone | Antifection | |
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -se... | |||
TN3707 | Coronarin B | Antifection | |
Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity. | |||
TN6009 | Pseudopalmatine | ||
Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM. | |||
TN1442 | Betulinic acid methyl ester | Antifection | |
Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis. | |||
TN3583 | Canophyllal | Antifection | |
Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. | |||
TN4443 | Lipiferolide | Telomerase , Antifection | |
Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytoto... | |||
TN2867 | 3,4,5-Trimethoxyphenyl-(6-O-galloyl)-O-beta-D-glucopyranoside | Antifection | |
3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside shows in vitro antiplasmodial activity. | |||
T11509 | Guanfu base H | Atisinium chloride | Others |
Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM). | |||
TN1930 | Methylenetanshinquinone | Antifection | |
Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. | |||
TN3124 | 5-Hydroxysophoranone | Antibacterial , Parasite , Antifection | |
T75568 | Z-Antiepilepsirine | ||
Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1]. | |||
TN1834 | Kobusin | Others , NOS , NF-κB | |
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ... | |||
TN5061 | Stephanine | Adrenergic Receptor , Antifection | |
l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activitie... | |||
TN5201 | Uncarinic acid E | BCL , MEK , Caspase , PI3K , Antifection , p53 | |
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu... | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... | |||
TN2190 | Scoulerine | Apoptosis , Beta-Secretase , BACE , Parasite | |
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. |