|
T3206 |
NKL 22
|
Histone Deacetylase Inhibitor IV,PAOA |
HDAC
|
|
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. |
|
T2157 |
M344
|
MS 344,Histone Deacetylase Inhibitor III |
HDAC
|
|
M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. |
|
T3193 |
Pimelic diphenylamide 106
|
Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 |
HDAC
|
|
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. |
|
T6055 |
Quisinostat
|
JNJ-26481585 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... |
|
T6481 |
Droxinostat
|
NS 41080 |
Apoptosis
,
HDAC
|
|
Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. |
|
T6865 |
Quisinostat dihydrochloride
|
Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... |
|
T8508 |
HDAC-IN-3
|
GSK3117391A |
HDAC
|
|
HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. |
|
T3983 |
TMP195
|
TFMO 2,TMP 195 |
HDAC
|
|
TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor. |
|
T3358 |
ITSA-1
|
ITSA1 |
HDAC
|
|
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors. |
|
T14947 |
CHDI-390576
|
|
HDAC
|
|
CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, HDAC 9, and can be used in cancer research. |
|
T8517 |
Belinostat
|
PX105684,PXD101,PXD-101 |
HDAC
,
Autophagy
|
|
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity. |
|
T73515 |
MC2590
|
|
Apoptosis
,
HDAC
|
|
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis. |
|
T21505 |
Suberoyl bis-hydroxamic acid
|
SBHA,Suberohydroxamic acid |
Apoptosis
,
HDAC
|
|
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ... |
|
T17028 |
Tefinostat
|
CHR-2845 |
HDAC
|
|
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefino... |
|
T16962 |
SW-100
|
|
HDAC
|
|
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the... |
|
T1583 |
Vorinostat
|
MK0683,suberoylanilide hydroxamic acid,SAHA |
Apoptosis
,
Mitophagy
,
Virus Protease
,
HDAC
,
Autophagy
|
|
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i... |
|
T2078 |
Fimepinostat
|
CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 |
Apoptosis
,
PI3K
,
HDAC
|
|
Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C... |
|
T77334 |
HDAC-IN-57
|
|
Apoptosis
,
HDAC
|
|
HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ... |
|
T6678 |
Splitomicin
|
1-Naphthalenepropanoic Acid |
Sirtuin
,
HDAC
|
|
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
|
T1852 |
Rac-Belinostat
|
NSC726630,PXD101,PX-105684 |
HDAC
|
|
Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptos... |
|
T27083 |
Crebinostat
|
|
Epigenetic Reader Domain
,
Histone Acetyltransferase
,
HDAC
|
|
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct... |
|
T3661 |
Citarinostat
|
ACY241,HDAC-IN-2 |
HDAC
|
|
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ... |
|
T11543 |
HDAC-IN-5
|
|
HDAC
|
|
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. |
|
T25630 |
Largazole
|
|
Others
|
|
Largazole is a potent and selective histone deacetylase (HDAC) inhibitor and antiproliferative agent from Symploca. |
|
T34635 |
SHP-141
|
SHP141,SHP 141 |
Others
|
|
SHP-141 is a topical preparation containing histone deacetylase (HDAC) inhibitor, with potential anti-tumor activity. |
|
T26731 |
Azumamide E
|
|
Others
|
|
Azumamide E, a cyclotetrapeptide isolated from the sponge Mycale izuensis, is a carboxylic acid containing natural histone deacetylase (HDAC) inhibitor. |
|
T63747 |
MC4355
|
|
Others
|
|
MC4355 is a dual inhibitor of EZH2 and histone deacetylase (HDAC). |
|
T79543 |
J27644
|
|
HDAC
|
|
J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1]. |
|
T36686 |
Ac-Arg-Gly-Lys(Ac)-AMC
|
|
|
|
Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluor... |
|
T62500 |
WW437
|
|
Others
|
|
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo. |
|
T61630 |
HDAC-IN-42
|
|
Others
|
|
HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and in... |
|
T36110 |
L-Pyrohomoglutamic Acid
|
|
Others
|
|
L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors.
1.Pomplun, S., Wang, Y., Kirschner, A.... |
|
T79541 |
HDAC-IN-61
|
|
HDAC
|
|
HDAC-IN-61 (compound 12k) is a potent, orally active inhibitor of histone deacetylase (HDAC) with anticancer activity, exhibiting an IC50 of 30 nM against Bel-7402 cells, and is utilized for cancer research [1]. |
|
TP1836 |
BMf-BH3
|
|
|
|
BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetyl... |
|
T78766 |
HDAC-IN-59
|
|
HDAC
|
|
HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage, arrests the cell cycle at the G2/M phase, and triggers the mi... |
|
T21749 |
4-iodo-SAHA
|
|
Others
|
|
4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM for Skbr3, HT29, U937, JA16, and HL60 cell lines, resp... |
|
T36102 |
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
|
|
Others
|
|
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone dea... |
|
T36105 |
Coumarin-SAHA
|
coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA |
Others
|
|
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanili... |
|
T78767 |
HDAC-IN-60
|
|
HDAC
|
|
HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage, arrests the cell cycle at the G2/M phase, and triggers mitoch... |
|
T71110 |
Nanatinostat TFA
|
|
Others
|
|
Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inh... |
|
T63791 |
HDAC-IN-36
|
|
Others
|
|
HDAC-IN-36 is an orally active HDAC (histone deacetylase) inhibitor with an IC50 value of 11.68 nM for HDAC6. HDAC-IN-36 induces apoptosis, autophagy and inhibits migration. HDAC-IN-36 exhibits antitumor and antimetastat... |
|
T77937 |
JPS014 TFA
|
|
HDAC
,
PROTACs
|
|
JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a hi... |
|
T74453 |
JPS014
|
|
Others
|
|
JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is ... |
|
T74455 |
JPS035
|
|
Others
|
|
JPS035, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), specifically HDAC1/2. Its potent activity is associated with an... |
|
T79713 |
JMJD3/HDAC-IN-1
|
|
HDAC
|
|
Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone deacetylase, IC50 = 16 nM). It induces hypermethylation of his... |
|
T77938 |
JPS016 TFA
|
|
HDAC
,
PROTACs
|
|
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substa... |
|
T74456 |
JPS036
|
|
Others
|
|
JPS036, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), efficiently degrades class I histone deacetylase (HDAC), particularly HDAC1/2. Its activity results in a substantial inc... |
|
T74454 |
JPS016
|
|
Others
|
|
JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC). It serves as a potent HDAC1/2 degrader, resulting in a signific... |
|
T70195 |
NL-103
|
|
Others
|
|
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibito... |
|
T62072 |
HDAC-IN-47
|
|
Others
|
|
HDAC-IN-47 is an orally active histone deacetylase (HDAC) inhibitor with IC50 values of 19.75 nM, 57.8 nM, 40.27 nM, 5.63 nM and 302.73 nM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. HDAC-IN-47 can block the ... |
