|
T12490 |
Pitavastatin lactone
|
|
Others
|
|
Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes. |
|
T6031 |
GNE0877
|
GNE 0877,GNE-0877 |
LRRK2
|
|
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). |
|
T6714 |
URB-597
|
KDS-4103,FAAH Inhibitor II |
Mitophagy
,
FAAH
,
Autophagy
|
|
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. |
|
T3424 |
Ezutromid
|
BMN 195,VOX-C1100,SMT C1100 |
Others
|
|
Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ... |
|
T13373 |
YM17E
|
|
Acyltransferase
,
AChR
|
|
|
|
T20373 |
1-Phenylpyrrole
|
NSC16581,NSC-16581,NSC 16581 |
Others
|
|
1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver. |
|
T22148 |
(S)-Lisofylline
|
|
Others
|
|
(S)-Lisofylline is the inactive optical enantiomer of (R)-lisofylline which is an anti-inflammatory agent. (S)-Lisofylline is exclusively converted to pentoxifylline in human liver microsomes. |
|
T19526 |
Pradefovir mesylate
|
Pradefovir mesilate,Remofovir mesylate,Hepavir B |
P450
|
|
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM. |
|
T73040 |
CYP1B1-IN-4
|
|
P450
|
|
CYP1B1-IN-4, a 2,4-diarylthiazole compound, exhibits selective inhibition of CYP1B1 (IC50=0.2 nM), demonstrating minimal cytotoxicity and high stability in human and rat liver microsomes [1]. |
|
T11235 |
Estradiol 3-sulfamate
|
E2MATE,BLE 00084,ES-J 995 |
Estrogen Receptor/ERR
|
|
Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in t... |
|
T11339 |
Furegrelate sodium
|
U-63557A |
PPAR
|
|
|
|
T27918 |
LY 43578
|
LY-43578,LY43578 |
P450
,
Aromatase
|
|
LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (IC50 of 0.3 and 5 μm, respectively) in rat liver microsomes.... |
|
T14983 |
Clomethiazole
|
Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE |
P450
,
GABA Receptor
|
|
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C... |
|
T27371 |
FR-167356
|
FR167356,FR 167356 |
ATPase
|
|
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces b... |
|
T3647 |
HTHQ
|
HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone |
Reactive Oxygen Species
|
|
HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely e... |
|
T14953 |
Chloroquinoxaline sulfonamide
|
Chloroquinoxaline,NSC-339004 |
Antibiotic
|
|
Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a structural analog of sulfaquinoxaline, an organic micropollutant that is frequently detected at low levels in drinking water and surface water.Chloroquinoxaline sulf... |
|
T21254 |
Vonoprazan Fumarate
|
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 |
Proton pump
|
|
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... |
|
T28449 |
Pradefovir
|
ICN-2001-3,MB-6866,ICN-20013,MB-06866,Remofovir |
HBV
|
|
Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converte... |
|
T23549 |
YM 511
|
|
P450
,
Aromatase
|
|
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly ... |
|
T37149 |
Carbamazepine 10,11-epoxide
|
|
Others
|
|
Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e... |
|
T27061 |
CP-24879 hydrochloride
|
CP-24879 HCl |
Others
|
|
CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an... |
|
T25428 |
Flufiprole
|
Rizazole,Butene-fipronil |
|
|
Flufiprole is used as a phenylpyrazole pesticide. It has enantioselective metabolism in human and rat liver microsomes. |
|
T27567 |
IAA-94
|
IAA94,IAA 94 |
|
|
IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM. |
|
T37210 |
5-hydroxy Indomethacin
|
|
|
|
5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes.
1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fet... |
|
T70091 |
IACS-4759
|
|
|
|
IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes. |
|
T37229 |
(±)8,9-DiHETE
|
|
|
|
(±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosa... |
|
T32912 |
Lu49888 HCl
|
Azidopamil,LU49888,LU 49888,Ludopamil,LU-49888 |
|
|
LU 49888 is a photoaffinity analog of verapamil that has been used to identify specific binding sites for phenylalkylamines of calcium channels present in rabbit skeletal muscle microsomes. |
|
T37306 |
6-hydroxy Chlorzoxazone
|
6-hydroxy Chlorzoxazone,NSC 24955 |
|
|
6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone. [1] It is formed by metabolism of chlorzoxazone by the cytochrome P450 (CYP) isoform CYP2E1 in human hepatic microsomes. |
|
T37430 |
Mirtazapine N-oxide
|
|
|
|
Mirtazapine N-oxide is a metabolite of mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 in human liver microsomes. |
|
T36666 |
Dehydro Warfarin
|
|
|
|
Dehydro warfarin is a metabolite of (±)-warfarin .1It is formed from (±)-warfarin by rat liver microsomes.
1.Kaminsky, L.S., Fasco, M.J., and Guengerich, F.P.Comparison of different forms of liver, kidney, and lung micro... |
|
T36794 |
Dolutegravir O-β-D-Glucuronide
|
|
|
|
Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized ... |
|
T40238 |
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
|
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium |
|
|
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in viv... |
|
T40239 |
Tenofovir-C3-O-C15-CF3 ammonium
|
Tenofovir-C3-O-C15-CF3 ammonium |
|
|
Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo. |
|
T35919 |
N-hydroxy Riluzole
|
|
|
|
N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes.
1.Sanderink, G.J., Bournique,... |
|
T35715 |
N-desmethyl Eletriptan
|
|
|
|
N-desmethyl Eletriptan is a metabolite of eletriptan .1It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes.
1.Evans, D.C., O’Connor, D., Lake, B.G., et al.Eletript... |
|
T13658 |
DMEA-PNU-159682
|
|
Others
|
|
DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule, including neomycin (MMDX) metabolites from liver microsomes and effective ADC cytotoxin PNU-159682. |
|
T25826 |
MMV024101
|
MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101 |
|
|
MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent comp... |
|
T28156 |
Nepaprazole
|
TY-11345,TY11345,TY 11345 |
|
|
Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being... |
|
T35997 |
22-HDHA
|
|
|
|
22-HDHA is an oxidation product of docosahexaenoic acid . In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 micr... |
|
T17802 |
DBCO-PEG4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of ... |
|
T35512 |
(±)16-HDHA
|
|
|
|
(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stre... |
|
T36607 |
(±)8-HDHA
|
|
|
|
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress... |
|
T64190 |
Keap1-Nrf2-IN-12
|
|
|
|
eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes. |
|
T36058 |
Dibutyl-3-Hydroxybutyl Phosphate
|
|
|
|
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to co... |
|
T18302 |
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 ... |
|
T61136 |
Enpp-1-IN-11
|
|
|
|
Enpp-1-IN-11 (compound 23) is a highly potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1), with a Ki value of 45 nM. It demonstrates excellent stability in human and mouse plasma and exhibit... |
|
T37440 |
C2 Adamantanyl Galactosylceramide (d18:1/2:0)
|
|
|
|
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocer... |
|
T73148 |
ACT-777991
|
|
|
|
ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells tow... |
|
T36840 |
(R)-Omeprazole (sodium salt)
|
|
|
|
(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxid... |
|
T18292 |
Mal-PEG4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, D... |
