|
T8450 |
TCN 213
|
TCN213 |
NMDAR
|
|
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B |
|
T5104 |
BTSA1
|
|
Apoptosis
,
BCL
|
|
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. |
|
T1447 |
Fenclonine
|
Fenchlonine,PCPA,CP-10188,4-Chloro-DL-phenylalanine,DL-4-Chlorophenylalanine |
Hydroxylase
|
|
Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to dep... |
|
T2131 |
Articaine hydrochloride
|
Ultracaine,Articaine HCl,Hoe-045 |
Sodium Channel
|
|
Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. |
|
T0150 |
Hydroxyhexamide
|
(±)-Hydroxyhexamid |
Potassium Channel
,
Drug Metabolite
|
|
Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent. |
|
T12145L |
N-Desethylsunitinib hydrochloride
|
|
VEGFR
,
PDGFR
,
c-Kit
|
|
N-Desethylsunitinib hydrochloride is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ, and KIT inhibitor. |
|
T7806 |
Licarbazepine
|
10,11-hydroxy-10,11 Dihydrocarbamezer |
Others
|
|
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. |
|
T0785 |
Dexchlorpheniramine Maleate
|
S-(+)-Chlorpheniramine maleate salt |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Dexchlorpheniramine Maleate (S-(+)-Chlorpheniramine maleate salt) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active d... |
|
T22431 |
SU5204
|
3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one |
EGFR
,
VEGFR
,
HER
|
|
SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2) |
|
T0182L2 |
(±) Clopidogrel hydrogen sulfate
|
Plavix,Clopidogrel hydrogen sulfate,Iscover |
P2Y Receptor
|
|
(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cerebrovascular disease, periph... |
|
TP1277 |
Bradykinin
|
|
Endogenous Metabolite
,
Bradykinin Receptor
|
|
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol... |
|
T13177 |
Taquidil
|
|
|
|
Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is an orally effective antiarrhythmic agent, structurally and ... |
|
T20714 |
Levolansoprazole
|
(S)-Lansoprazole,(-)-Lansoprazole |
Proton pump
|
|
Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50:... |
|
T1545 |
Levamlodipine
|
(S)-Amlodipine,S-amlodipine |
Calcium Channel
|
|
Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and an... |
|
T4284 |
Levamlodipine besylate
|
(S)-Amlodipine Besylate (103129-82-4(free base)) |
Calcium Channel
|
|
Levamlodipine besylate ((S)-Amlodipine Besylate (103129-82-4(free base))) , also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipi... |
|
T32886 |
Lorzafone
|
Lorzafonum,45-0088S |
|
|
Lorzafone is used in the detection & analysis of pharmacologically active benzodiazepines. |
|
T16272 |
Naproxen etemesil
|
LT-NS 001,MX 1094 |
PDE
|
|
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen o... |
|
T21155 |
Metoprolol acid
|
Atenolol acid,H117-04,H 117/04,SL 77-010 |
|
|
Metoprolol acid is a urinary metoprolol metabolite and doesn't work pharmacologically. |
|
T28422 |
Pirlindole free base
|
Pirlindole,Pyrazidol |
|
|
Pirlindole is a reversible inhibitor of monoamine oxidase A (RIMA). It is structurally and pharmacologically related to metralindole. |
|
T10351 |
Aprocitentan D4
|
ACT-132577 D4 |
Others
|
|
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2... |
|
T13713 |
GP531
|
|
AChR
|
|
|
|
T23959 |
Dactylyne
|
|
|
|
Dactylyne is a new drug metabolism inhibitor of marine origin. It was isolated from the sea hare Aplysia dactylomela and characterized pharmacologically. |
|
T25691 |
Levamlodipine gentisate
|
(S)-Amlodipine gentisate,(S)-(-)-Amlodipine gentisate |
|
|
Levamlodipine gentisate is a pharmacologically active enantiomer of amlodipine. Amlodipine is the dihydropyridine calcium channel blocker used as an antihypertensive and antianginal drug. |
|
T16389 |
Omidenepag
|
|
Prostaglandin Receptor
|
|
Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays binding affinities (IC50: 10 nM for h-EP2). |
|
T23962 |
DA-E 5090
|
DA-E-5090,DA-E5090,DA E 5090 |
|
|
DA-E 5090 is a pharmacologically active metabolite of E 5090, is an interleukin-1 antagonist. DA-E 5090 is a novel inhibitor of IL-1 generation, in vitro inhibitory effects on the generation of IL-1 by human monocytes. |
|
T1077L |
Fluvoxamine
|
|
|
|
Fluvoxamine (DU-23000) is an antidepressant that acts pharmacologically as a selective serotonin reuptake inhibitor. |
|
TMIH-0024 |
10,11-Dihydro-10-hydroxycarbamazepine-d4
|
rac-Licarbazepine-d4 |
|
|
10,11-Dihydro-10-hydroxycarbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxycarbamazepine. 10,11-Dihydro-10-hydroxycarbamazepine has a CAS number of 29331-92-8. Licarbazepine is the pharmacologically act... |
|
T19360 |
Hydroxy bosentan
|
Ro 48-5033 |
Others
|
|
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Hydroxy bosentan assists BOS pharmacologically, retaining 10%-20% activities. |
|
T37391 |
PSEM 308 hydrochloride
|
|
|
|
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neuro... |
|
T69983 |
Ixazomib citrate EtOH
|
|
|
|
Ixazomib citrate, also known as MLN9708, is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. MLN9708, after hydrol... |
|
T41192 |
CNV Dopamine
|
|
|
|
CNV Dopamine is a carboxynitroveratryl (CNV)-caged dopamine; releases dopamine upon ultraviolet light stimulation (365 nm). Induces dopaminergic currents upon photolysis in brain slices expressing wild-type or GFP-labele... |
|
T69657 |
GS-441524 HCl
|
|
|
|
GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infecti... |
|
TMIH-0301 |
Levolansoprazole-d4
|
|
|
|
Levolansoprazole-d4 is a deuterated compound of Levolansoprazole. Levolansoprazole has a CAS number of 138530-95-7. Levolansoprazole, a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in pariet... |
|
T82805 |
Butaprost free acid
|
|
|
|
(R)-Butaprost (free acid) is a prostaglandin E2 (PGE2) analog exhibiting high EP2 receptor subtype selectivity, commonly used to delineate EP receptor expression in human and animal tissues and cells. In 1986, Gardiner i... |
