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T8987 |
Epiblastin A
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Casein Kinase
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Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). |
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T21679 |
4'-bromo-Resveratrol
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Sirtuin
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4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) |
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T2040 |
OAC1
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BAS 00287861 |
OCT
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OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process. |
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T30577 |
BRD0418
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BRD 0418,BRD-0418 |
Others
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BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it. |
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T83972 |
NOX-6-18
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GPR132 antagonist 1,GPR132-B-160 |
GPR
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NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain. |
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T4100 |
AS8351
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NSC51355,AS-8351,AS 8351 |
Histone Demethylase
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AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas... |
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T2019 |
OAC2
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OCT
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OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibrobl... |
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T24754 |
Hh-Ag1.5
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SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
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Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
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T3031 |
A 83-01
|
ALK5 Inhibitor IV,A8301 |
ALK
,
TGF-beta/Smad
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A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult... |
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T60839 |
SLMP53-1
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p53
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SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inh... |
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T64066 |
CSF1R-IN-3
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c-Fms
,
CSF-1R
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CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef... |
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T8768 |
MM-102 TFA
|
HMTase Inhibitor IX TFA |
Histone Methyltransferase
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MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WD... |
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T77493 |
Murlentamab
|
3C23K,GM102 |
Others
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Murlentamab (GM102) is a humanized anti-AMhRII antibody. Murlentama has potential antitumor activity that induces macrophage-mediated antitumor-dependent cell-mediated cytotoxic effects (ADCC). Murl can stimulate the pro... |
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T23271 |
RSC-133
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Others
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promotes the reprogramming of human somatic cells to pluripotent stem cells |
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T24489 |
MM-401
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MM401 |
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MM-401 is a specific inhibitor of histone H3K4 methyltransferase MLL1 activity that acts by reprogramming mouse epiblast stem cells to naive pluripotency. |
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T41207 |
Tocriscreen Stem Cell Library
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|
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The Tocriscreen Stem Cell Library is a bioactive compound library composed of 120 compounds supplied in DMSO (100 μL 10 mM solutions). This compound library contains a diverse range of small molecules to find the best co... |
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T78751 |
DG1
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DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing the expression of CD26, ET-1, FGF-1, and EGF. Additionally,... |
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T79260 |
MCI
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Reactive Oxygen Species
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MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging a... |
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T78520 |
CYT296
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|
Others
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CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibro... |
