|
T21899 |
Misonidazole
|
SR-1354,SR1354,Ro 7-0582 |
GPX
|
|
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors. |
|
T2607 |
MSDC 0160
|
CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 |
Others
,
IGF-1R
,
Mitochondrial Metabolism
|
|
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. |
|
T2046 |
Nimorazole
|
Nimorazol,Nitrimidazine,K-1900,Naxogin |
Others
,
Antibiotic
,
Parasite
|
|
Nimorazole (Nimorazol) is a nitroimidazole anti-infective. |
|
T5002 |
Methyl Aminolevulinate Hydrochloride
|
5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride |
Others
|
|
Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) is commonly used in photosentizer reagents for photodynamic therapy to treat conditions such as Acne vulgaris and hypertrophic scarring. |
|
T81483 |
Photosensitizer-2
|
|
|
|
Photosensitizer-2 (compound 1), an organic D-π-A sensitizer, exhibits antitumor properties and potent phototoxicity due to an acrylic acid moiety. It demonstrates significant activity against HeLa cells, with IC 50 value... |
|
T75353 |
Photosensitizer-1 hydrochloride
|
|
|
|
Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer [1] . |
|
T75352 |
Photosensitizer-1
|
|
|
|
Photosensitizer-1 (Compound CLB-13) is a photosensitizer [1] . |
|
T74392 |
Antimicrobial photosensitizer-1
|
|
|
|
Antimicrobial Photosensitizer-1 demonstrates significant potential as an effective agent for treating infections caused by pathogenic microorganisms, with notable antimicrobial efficacy observed in S. aureus-infected mou... |
|
T74601 |
Antitumor photosensitizer-3
|
|
|
|
Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laser irradiation. This compound demonstrates reduced skin phototoxicity c... |
|
T79711 |
Antitumor photosensitizer-4
|
|
Apoptosis
|
|
Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. This photosensitizer (PS) induces apoptosis and reactive oxygen speci... |
|
T82998 |
Antitumor photosensitizer-1
|
|
|
|
Antitumor Photosensitizer-1 (Compound 8) is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, positioning it as a promising new candidate for photodynamic therap... |
|
T82997 |
Antitumor photosensitizer-2
|
|
|
|
Compound 11, also known as Antitumor Photosensitizer-2, is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, representing a promising candidate for photodynamic ... |
|
T17216 |
Valspodar
|
PSC 833 |
P-gp
|
|
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer. |
|
T25372 |
EMD57033
|
EMD-57033,(+)-EMD 57033,EMD 57033 |
Calcium Channel
,
Carbonic Anhydrase
|
|
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction. |
|
T27303 |
Farglitazar
|
GI-262570,GI-2570,GW 262570X,GI 262570,GI262570 |
PPAR
|
|
Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer that inhibits stellate cell activation by activating receptor γ via oxidative enzymes proliferators and is used in the study of diabetes. |
|
T4639 |
Azemiglitazone
|
MSDC 0602 |
Mitochondrial Metabolism
,
mTOR
|
|
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes. |
|
T0334 |
Rosiglitazone
|
BRL49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. |
|
T38715 |
MSDC-0602K
|
MSDC-0602K,Azemiglitazone potassium |
PPAR
|
|
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (... |
|
T26585 |
AK301
|
AK-301,AK 301 |
Apoptosis
,
Microtubule Associated
|
|
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a ... |
|
T16785 |
Ropidoxuridine
|
IPdR |
Others
|
|
Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) p... |
|
T2530 |
Levosimendan
|
OR1259,OR1855 |
Potassium Channel
,
PDE
,
Carbonic Anhydrase
,
Autophagy
|
|
Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without ... |
|
T29283 |
1,4-Dibenzyloxybenzene
|
|
|
|
1,4-Dibenzyloxybenzene is a aromatic sensitizer. |
|
T34071 |
Piperphentonamine HCl
|
PPTA |
|
|
Piperphentonamine HCL is a potential calcium sensitizer for the treatment of heart failure. |
|
T31492 |
Dimethylaminopropyl lauramide
|
|
|
|
Dimethylaminopropyl lauramide is a skin sensitizer. |
|
T21270 |
Isometronidazole
|
R.P. 8979,Isometronidazole, Izoklion |
|
|
Isometronidazole is a hypoxic cell sensitizer. |
|
T34334 |
RK 29
|
RK29,RK-29 |
|
|
RK 29 has hypoxic cell sensitizer properties. |
|
T19421 |
Methyl aminolevulinate
|
|
Others
|
|
Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX. Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). |
|
T70813 |
DTP348
|
|
|
|
DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide componen... |
|
T18960 |
D149 Dye
|
D149,Indoline dye D149 |
Others
|
|
D149 Dye is an indoline-based dye and a high-extinction-coefficient metal-free organic sensitizer. |
|
T32199 |
ISF-402
|
ISF 402 |
|
|
ISF-402 is an insulin sensitizer that may be used in the treatment of type 2 diabetes, dispersing the hexamer insulin in vitro and enhancing the activity of the hexamer insulin more than the monomer liproline insulin. |
|
T35265 |
YM-440
|
YM440,YM 440 |
|
|
YM-440 is a novel hypoglycemic agent, an insulin sensitizer, that may be used for the treatment of type 2 diabetes mellitus by reducing glucose 6-phosphatase activity in obese Zucker rats and inhibiting liver glucose out... |
|
T35243 |
YD2
|
YD-2,YD 2 |
|
|
YD2 is a porphyrin sensitizer. YD2 is a useful material for making solar cell. Cosensitization of YD2-o-C8 with another organic dye enhances the performance of the device, leading to a measured power conversion efficienc... |
|
T69011 |
Lobeglitazone
|
|
|
|
Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat ce... |
|
T15748 |
LG100754
|
UVI 2112 |
PPAR
|
|
LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPAR... |
|
T78463 |
Calconcarboxylic acid
|
|
|
|
Calconcarboxylic acid, an azo dye, serves as a silver-ion sensitizer for staining proteins in SDS-PAGE gels. It enhances silver binding to protein bands or spots through the formation of a silver-dye complex and augments... |
|
T74089 |
Mifamurtide TFA
|
|
|
|
Mifamurtide TFA (MTP-PE TFA), a muramyl dipeptide (MDP) analog, acts as a nonspecific immunomodulator by activating macrophages and monocytes to stimulate the immune response. As an orphan agent and a specific NOD2 ligan... |
