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T9641 |
Aβ42-IN-2
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Gamma-secretase
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Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1]. |
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T10211 |
Aβ42-IN-1
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Others
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Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 show... |
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T10443 |
Aβ42-IN-1 free base
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Others
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Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice.... |
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T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
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Compound W |
Gamma-secretase
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3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). |
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T10532 |
BI-1408
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Others
,
Gamma-secretase
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BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42). |
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T2262 |
Itanapraced
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CHF5074,CSP-1103 |
Beta Amyloid
,
Gamma-secretase
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Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). |
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T6125 |
Semagacestat
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LY450139 |
Beta Amyloid
,
Gamma-secretase
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Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). |
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T6249 |
Avagacestat
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BMS-708163 |
Gamma-secretase
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Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
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T6202 |
DAPT
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LY-374973,GSI-IX |
Apoptosis
,
Beta Amyloid
,
Gamma-secretase
,
Autophagy
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DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. |
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T7857 |
DO1
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Disperse Orange 1 |
Others
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DO1 (Disperse Orange 1) is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations |
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T63208 |
Aβ-IN-1
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Gamma-secretase
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Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma... |
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T62263 |
γ-Secretase modulator 13
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Gamma-secretase
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γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors. |
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T10782 |
CGP52411
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DAPH |
EGFR
,
Beta Amyloid
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CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42... |
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T16773 |
Ro 90-7501
|
RO-90-7501 |
Apoptosis
,
Phosphatase
,
ATM/ATR
,
Gamma-secretase
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Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest... |
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T6478 |
Donepezil Hydrochloride
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Aricept,BNAG,E2020,Donepezil HCl |
AChR
,
AChE
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Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM). |
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T6708 |
Tolcapone
|
Tasmar,Ro 40-7592 |
Apoptosis
,
Beta Amyloid
,
Transferase
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Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. |
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T4364 |
Aftin-4
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Aftin 4,Aftin4 |
Beta Amyloid
,
Gamma-secretase
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Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... |
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T11361 |
γ-Secretase modulator 4
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Others
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γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively. |
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T27500 |
GSK-B
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GSK-B, a potent γ-secretase modulator, decreases Aβ42, increases Aβ38 with no effect on Aβ40 levels. |
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T37200 |
Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
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Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in... |
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T63163 |
CSPM
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cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity. |
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T80104 |
Z-Phe-Ala-diazomethylketone
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PADK |
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Z-Phe-Ala-diazomethylketone directly binds to Aβ42 monomers and small oligomers, effectively inhibiting the formation of Aβ42 dodecamers and preventing Aβ42 fibrillogenesis in solution. This compound holds potential for ... |
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T14690 |
BMS 433796
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BMS-289948,BMS-299897 |
Beta Amyloid
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BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease. |
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T37472 |
TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
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TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's... |
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T24971 |
2002-H20
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2002 H20,2002H20 |
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2002-H20 is an Aβ42-induced cytotoxicity inhibitor. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity. |
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T61881 |
γ-Secretase modulator 12
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γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretas... |
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T71098 |
AZ3971
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AZ3971 is a potent BACE1 inhibitor. AZ3971 blocks BACE1-mediated cleavage of APP and inhibits Aβ42 production HEK cells overexpressing the APP protein which carries the Swedish mutation (HEK.APPswe). |
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T10589L |
BPN-15606
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Others
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BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits fav... |
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T76401 |
Amyloid β-Protein (33-42) (TFA)
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Amyloid β-Protein (33-42) TFA, a fragment encompassing residues 33-42 of the β-amyloid protein, mitigates the toxicity induced by Aβ42 [1]. |
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T79752 |
DDC 2′,3′-O-disulfate
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DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1]. |
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T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
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Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne... |
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T82599 |
DDC 3′-O-β-D glucuronide
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Drug Metabolite
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Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential utility in Alzheimer's disease research [1]. |
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T10589 |
BPN-15606 besylate (1914989-49-3 free base)
|
BPN-15606 besylate |
Others
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BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: 7 nM and 17nM). |
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T64081 |
BPN-15606 besylate
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BPN-15606 besylate is a potent, orally active γ-secretase regulator (GSM) that reduces the production of Aβ42 (IC50: 7 nM) and Aβ40 (IC50: 17 nM) by SHSY5Y neuroblastoma cells. BPN-15606 besylate exhibited good PK/PD pro... |
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T76395 |
(Met(O)35)-Amyloid β-Protein (1-42)
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(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of Aβ40. This compound is utilized in Alzheimer’s disease (AD) re... |
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T81299 |
Remternetug
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LY3372993 |
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Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42. It specifically binds to the pyroglutamate-modified form of Aβ, which is impl... |
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T70807 |
Lanabecestat HCl
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Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant do... |
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TP2056 |
Acetyl-Calpastatin(184-210)(human)
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Acetyl-Calpastatin (184-210) (human) |
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Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. |
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T79022 |
BACE1-IN-13
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Beta-Secretase
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BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ... |
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T63638 |
γ-Secretase modulator 11 hydrochloride
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γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM). γ-Secretase modulator 11 hydrochloride significantly reduces brain Aβ42 levels and rescues the cognitive deficits ... |
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T64258 |
Gamma-secretase modulator 5
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gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60... |
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T63216 |
γ-Secretase modulator 11
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5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, was able to cause a significant reduction in b... |
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T76425 |
(Glu20)-Amyloid β-Protein (1-42)
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(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly. This is attributed to the Glu20 mutation, which diminishes Aβ42's tendency to aggregate and inhibits the accum... |
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T37369 |
Amyloid-β (1-8, A2V) Peptide
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Amyloid-β (1-8, A2V) Peptide |
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Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor ... |
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T36639 |
Donecopride (fumarate hydrate)
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Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ... |
