|
T9552 |
BAZ1A-IN-1
|
|
Epigenetic Reader Domain
|
|
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity ag... |
|
T6303 |
CCT128930
|
|
Akt
,
PKA
,
S6 Kinase
,
Autophagy
|
|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. |
|
T2325 |
Neratinib
|
HKI-272 |
EGFR
,
HER
|
|
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively. |
|
T20029 |
Buformin hydrochloride
|
NSC528218,NSC-528218,NSC 528218 |
AMPK
|
|
Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and... |
|
T4459 |
PK11000
|
|
DNA Alkylator/Crosslinker
|
|
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. |
|
T6303L |
CCT128930 hydrochloride
|
CCT128930 hydrochloride(885499-61-6 Free base) |
Apoptosis
,
Akt
,
PKA
,
mTOR
,
Autophagy
|
|
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28... |
|
T7947 |
FT113
|
|
Fatty Acid Synthase
|
|
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity |
|
T34173 |
P-SCN-Bn-HOPO
|
|
|
|
p-SCN-Bn-HOPO is an excellent bifunctional chelating agent for (89)Zr ImmunoPET, with low background, good tumor-organ contrast, and importantly, very low bone uptake for BT474 breast cancer imaging. |
|
T79311 |
CNBCA
|
|
|
|
CNBCA, a selective and potent competitive inhibitor of the SHP2 enzyme, exhibits an IC50 value of 0.87 μM. It binds to the full-length SHP2, effectively inhibiting its enzyme activity, as well as impeding pAkt and pERK1/... |
|
T35874 |
CC260
|
|
|
|
CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell ... |
