|
T60075 |
Dopamine D2 receptor agonist-2
|
Dopamine D2 Receptor |
Dopamine Receptor
|
|
Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor. |
|
T11077 |
Dopamine D2 receptor antagonist-1
|
|
Others
|
|
Dopamine D2 Receptor Antagonist-1 functions as a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R), demonstrating sub-millimolar affinity. |
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T7635 |
Raclopride
|
|
Dopamine Receptor
|
|
Raclopride is a selective antagonist of dopamine D2/D3 receptor. |
|
T6112 |
Doxercalciferol
|
TSA 840,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2 |
Others
|
|
Doxercalciferol (TSA 840) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
|
TQ0084 |
Lumateperone Tosylate
|
ITI-007 |
Dopamine Receptor
,
5-HT Receptor
|
|
lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM). |
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T21069 |
Lumateperone
|
ITI 722,ITI722,ITI-007,ITI007 |
5-HT Receptor
|
|
Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM). |
|
T4007 |
Eticlopride hydrochloride
|
|
Dopamine Receptor
|
|
Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM). |
|
T0280 |
Spiperone
|
Spiroperidol,Spiropitan |
Dopamine Receptor
|
|
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. |
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T16392 |
ONC206
|
|
Dopamine Receptor
|
|
ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity. |
|
T8136 |
Perospirone hydrochloride
|
Perospirone HCl,SM-9018 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
|
T2226 |
Pergolide mesylate
|
Pergolide mesylate salt,LY127809,Pergolide methanesulfonate |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES. |
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T7943 |
Fluphenazine decanoate
|
|
Dopamine Receptor
|
|
Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. |
|
T3431 |
Pardoprunox hydrochloride
|
SLV-308 hydrochloride,DU-126891 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept... |
|
T12861 |
SB-277011
|
SB-277011A |
Dopamine Receptor
|
|
SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively. |
|
T10168 |
5-HT1A modulator 1
|
5-HT1Amodulator1 |
Phospholipase
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T2564 |
Cis-(Z)-Flupentixol dihydrochloride
|
Emergil,Flupenthixol dihydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
cis-(Z)-Flupentixol dihydrochloride (Emergil) is a dopamine receptor antagonist. |
|
T10213 |
A-437203
|
ABT-925,A37203,Lu201640 |
Dopamine Receptor
|
|
A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ff old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM. |
|
T1069 |
Metoclopramide hydrochloride
|
Maxolon,Metoclopramide HCl |
Dopamine Receptor
,
5-HT Receptor
,
AChR
|
|
Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic. |
|
T21337 |
Lurasidone
|
SM-13496 |
Dopamine Receptor
,
5-HT Receptor
|
|
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM). |
|
T8382 |
Cariprazine hydrochloride
|
Cariprazine HCl,RGH188 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively) |
|
T1222 |
Trifluoperazine dihydrochloride
|
Trifluoperazine 2HCl,SKF5019,Urinox |
CaMK
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
P-gp
,
Autophagy
|
|
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. |
|
T7553 |
(+)-PD 128907 hydrochloride
|
|
Dopamine Receptor
|
|
(+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor . |
|
T4577 |
Cariprazine
|
RGH-188 |
Dopamine Receptor
,
5-HT Receptor
|
|
Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
|
T4616 |
Metoclopramide
|
5-Chloro-2-methoxyprocainamide |
Dopamine Receptor
,
5-HT Receptor
|
|
Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is ... |
|
T23232 |
Remoxipride hydrochloride
|
Remoxipride Hydrochloride Anhydrous,Roxiam,(S)-Remoxipride Hydrochloride |
Dopamine Receptor
|
|
Remoxipride hydrochloride (Roxiam) is a selective antagonist of D2 receptor with IC50s of 1.57 μM, ＞100 μM and 42 μM for D2 receptor, D1 receptor and α1-adrenoceptor. |
|
T9228 |
Propionylpromazine hydrochloride
|
Propiopromazine hydrochloride |
Dopamine Receptor
|
|
Propionylpromazine hydrochloride (Propiopromazine hydrochloride) is a dopamine receptor D2 (DRD2) antagonist. |
|
T70302 |
Fallypride
|
|
Dopamine Receptor
|
|
Fallypride is a potent and selective dopamine D2/D3 receptor antagonist. |
|
T0302 |
Triflupromazine hydrochloride
|
Neoprin,Fluopromazine hydrochloride,Fluorofen,Flumazin |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Autophagy
|
|
Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists. |
|
T22817 |
GSK 789472 hydrochloride
|
GSK-789472 HCl,1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride,4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one |
Dopamine Receptor
|
|
GSK 789472 hydrochloride is both a dopamine D3 receptor antagonist and a D2 partial agonist. |
|
T11799 |
L-745870 hydrochloride
|
|
Dopamine Receptor
|
|
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... |
|
T21446 |
Rotigotine Hydrochloride
|
Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,N-0923 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinp... |
|
T3187 |
Fluoroclebopride
|
|
Dopamine Receptor
|
|
Fluoroclebopride is a dopamine (DA) D2 receptor ligand. |
|
T60835 |
SKF83959
|
|
Dopamine Receptor
|
|
SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent ... |
|
T10683 |
Carmoxirole hydrochloride
|
EMD 45609 hydrochloride |
Dopamine Receptor
|
|
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo. |
|
T38754 |
Trazpiroben
|
TAK-906 |
Dopamine Receptor
|
|
Trazpiroben (TAK-906) is a selective dopamine D2/D3 receptor antagonist used in the study of gastroparesis. |
|
T15712 |
Laropiprant
|
MK-0524 |
Prostaglandin Receptor
|
|
Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM). |
|
T6142 |
PD128907 HCl
|
|
Dopamine Receptor
|
|
PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
|
T24613 |
PF-00217830
|
PF-217830 |
Dopamine Receptor
,
Serotonin Transporter
|
|
PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia. |
|
T7180 |
Sultopride hydrochloride
|
LIN-1418 hydrochloride |
Dopamine Receptor
|
|
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist. |
|
T1211 |
Levosulpiride
|
RV-12309,S-(-)-Sulpiride |
Dopamine Receptor
|
|
Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class. |
|
T1735 |
Lurasidone hydrochloride
|
Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antag... |
|
T17072 |
Thiethylperazine dimaleate
|
Toresten,Thiethylperazine maleate,Norzine |
Dopamine Receptor
,
Antibacterial
,
ABC
,
Histamine Receptor
|
|
Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic e... |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T5009 |
Trimethobenzamide hydrochloride
|
Ro 2-9578,Tribenzagan Hydrochloride |
Dopamine Receptor
,
Influenza Virus
|
|
Trimethobenzamide hydrochloride (Ro 2-9578) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. |
|
T10249 |
Adoprazine
|
SLV313 |
Others
|
|
Adoprazine (SLV313) is a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
|
T7632 |
Veralipride
|
(±)-Veralipride,LIR166 |
Dopamine Receptor
|
|
Veralipride ((±)-Veralipride) is an antagonist of D2 receptor. |
|
T14083 |
Abaperidone
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... |
|
T33816 |
Ordopidine
|
ACR-325,ACR 325,ACR325 |
Dopamine Receptor
|
|
Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and... |
|
T5842 |
Bromocriptine mesylate
|
CB-154 |
Dopamine Receptor
,
Autophagy
|
|
Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM) |
|
T14767 |
BP 897 hydrochloride
|
|
Dopamine Receptor
|
|
BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ... |
