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T8849 |
PF-9601N
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MAO
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PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD. |
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T21551 |
2-hexyl-4-Pentynoic Acid
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HDAC
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2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM. |
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T0825 |
Ebselen
|
SPI-1005,PZ-51,CCG-39161 |
Phosphatase
,
Virus Protease
,
Calcium Channel
,
COX
,
HIV Protease
|
|
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... |
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T50032 |
5-(2-furyl)-N-propylisoxazole-3-carboxamide
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Others
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5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxici... |
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T37081 |
HIOC
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|
Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant. |
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T16155 |
MSN-125
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|
Akt
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|
MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization in... |
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T3525 |
PD150606
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Cysteine Protease
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|
PD150606 is a selective nonpeptide calpain inhibitor with neuroprotective activity that inhibits μ-calpains and m-calpains.
Inhibits erythrocyanine-induced Ca2+ efflux and interferes with excitotoxicity-dependent motor n... |
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T68345 |
GTS511
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|
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GTS511 is a EAAT2 Activator. Pharmacokinetic profiles (PK) of GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats. GTS511 can be further develo... |
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T69202 |
NBQX sodium
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NBQX, also known as FG9202, is an AMPA receptor antagonist. NBQX blocks AMPA receptors in micromolar concentrations (~10–20 µM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotox... |
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T80210 |
TAT-GluN2BCTM
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|
DAPK
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|
TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated ex... |
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T69806 |
EGIS-8332
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|
|
|
EGIS-8332 is a potent and selective non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA/kainate ion channels and cell death. EGIS-8332 inhibited AMPA currents in rat cerebellar Purkinje cells and inhibited... |
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T37096 |
Sepimostat dimethanesulfonate
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|
|
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Sepimostat dimethanesulfonate (FUT-187), a chemical compound, demonstrates neuroprotective properties by antagonizing NR2B N-methyl-D-aspartate receptors at the NR2B subunit's Ifenprodil-binding site. This compound effec... |
