|
T64366 |
GSK3-IN-4
|
|
GSK-3
|
|
GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay. |
|
T9987 |
GSK3-IN-1
|
|
GSK-3
|
|
GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor. |
|
T73270 |
GSK3-IN-2
|
|
GSK-3
|
|
GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases. |
|
T73331 |
GSK3-IN-3
|
|
Mitophagy
,
GSK-3
|
|
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective... |
|
T24111 |
GSK3i XIII
|
GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII |
GSK-3
|
|
GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor. |
|
T76088 |
GSK3 Substrate, α, β subunit
|
|
|
|
GSK3 Substrate, α, β subunit, serves as a peptide substrate for Glycogen Synthase Kinase-3 (GSK-3), facilitating the measurement of GSK-3 activity [1]. |
|
T21956 |
GSK3β inhibitor II
|
|
GSK-3
|
|
GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD). |
|
T11468 |
GSK-3 inhibitor 1
|
|
GSK-3
|
|
GSK-3 inhibitor 1 is a GSK-3 inhibitor. |
|
T35555 |
GSK-3/CDK5/CDK2-IN-1
|
GSK-3/CDK5/CDK2-IN-1 |
|
|
GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1]. |
|
T15440 |
GSK376501A
|
|
PPAR
|
|
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes. |
|
T7195 |
GSK369796 Dihydrochloride
|
N-tert-butylisoquine |
Potassium Channel
,
Parasite
|
|
GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM) |
|
T6059 |
GSK343
|
|
Histone Methyltransferase
,
Autophagy
|
|
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. |
|
T5491 |
GSK3179106
|
|
c-RET
|
|
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
|
T15558 |
GSK319347A
|
|
IκB/IKK
|
|
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma. |
|
T11500L |
GSK3368715 dihydrochloride
|
EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl |
Histone Methyltransferase
|
|
|
|
T15437 |
GSK3145095
|
|
RIP kinase
|
|
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic. |
|
T9573 |
GSK3685032
|
|
DNA Methyltransferase
|
|
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c... |
|
T5745 |
GSK3326595
|
EPZ015938 |
Histone Methyltransferase
|
|
GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). |
|
T27475 |
GSK356278
|
GSK-356278,GSK 356278 |
PDE
|
|
GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio... |
|
T24109 |
GSK329
|
GSK 329,GSK-329 |
Others
|
|
GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury. |
|
T77671 |
GSK3a-IN-38
|
|
GSK-3
|
|
GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a. |
|
T27478 |
GSK3987
|
|
Liver X Receptor
|
|
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. |
|
T15438 |
GSK3186899
|
3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide,DDD-853651 |
Parasite
|
|
GSK3186899 is an inhibitor of Cdc2-related kinase 12 with an EC50 of 1.4 μM for L. donovani. |
|
T1941 |
GSK3787
|
|
PPAR
|
|
GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）. |
|
T72629 |
PfGSK3/PfPK6-IN-2
|
|
|
|
PfGSK3/PfPK6-IN-2, an effective dual inhibitor targeting Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6), exhibits potent inhibitory activity with IC50 values of 172 nM for PfGSK3 and 11 nM for PfPK6, respectively. This co... |
|
T62719 |
AChE/BACE1/GSK3β-IN-1
|
|
|
|
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD). |
|
T79021 |
GSK3839919A
|
|
|
|
GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase [1]. |
|
T27477 |
GSK366A
|
|
|
|
GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6. |
|
T69784 |
GSK3527497 HCl
|
|
|
|
GSK3527497 is a potent and selective inhibitor of Transient Receptor Potential Vanilloid‑4 (TRPV4) with IC50 = 12 nM) for the treatment of heart failure and respiratory diseases. GSK3527497 is a preclinical candidate sui... |
|
T74887 |
GSK3735967
|
|
|
|
GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimeth... |
|
T63977 |
GSK3739936
|
|
|
|
GSK3739936 is a potent inhibitor of HIV-1 allosteric integrase (IC50: 11.1 nM, EC50: 1.7 nM). GSK3739936 is also a weak inhibitor of CYP with an IC50 >24.3 μM. It has good pharmacokinetic properties with rapid absorption... |
|
T15439 |
GSK3395879
|
|
TRP/TRPV Channel
|
|
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4). |
|
T27476 |
GSK360A
|
GSK-360A,GSK 360A |
|
|
GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor. |
|
T32009 |
GSK321
|
GSK 321,GSK-321 |
|
|
GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia... |
|
T73929 |
(S,S)-GSK321
|
|
|
|
(S,S)-GSK321 is a (S,S)-enantiomer of GSK321 [1] . |
|
T63851 |
CDK9/10/GSK3β-IN-1
|
|
|
|
CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 μM and 1.725 μM, respectively. CDK... |
|
T22342 |
GSK3368715 3HCl
|
EPZ019997 3HCl,GSK3368715(EPZ019997) |
Histone Methyltransferase
|
|
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. |
|
T11493 |
GSK3004774
|
|
Others
|
|
GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR. |
|
T27473 |
GSK334429
|
GSK-334429,GSK 334429 |
|
|
GSK334429 is an antagonist of histamine H3 receptor. |
|
T27472 |
GSK317354A
|
GSK 317354A,GSK-317354A |
|
|
GSK317354A is a GRK2 inhibitor. |
|
T62080 |
GSK3494245
|
|
|
|
GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani at an IC50 of 0.16 μM, sandwiched between the β4 and β5 subunits. GSK349... |
|
T69786 |
GSK3491943
|
|
|
|
GSK3491943 is a potent TRPV4 inhibitor with IC50 = 3.2 nM. GSK3491943 is a potential agent for the treatment of heart failure and respiratory diseases. |
|
T35838 |
GSK3182571
|
|
|
|
GSK3182571 is a non-speci c kinase inhibitor[1]. |
|
T11494 |
GSK3532795
|
BMS-955176 |
Others
|
|
|
|
T11500 |
GSK3368715
|
EPZ019997 |
Histone Methyltransferase
|
|
|
|
T36088 |
GSK3β Inhibitor XI
|
GSK3β Inhibitor XI |
|
|
GSK3β Inhibitor XI has GSK3β inhibitory effect. |
|
T24110 |
GSK340
|
GSK=340,GSK 340 |
|
|
GSK340 is a BET inhibitor. |
|
T69785 |
GSK3527497
|
|
|
|
GSK3527497 is a novel potent and selective inhibitor of transient receptor potential vanilloid-4 (TRPV4). |
|
T26894 |
BRD0209
|
BRD-0209,BRD 0209 |
GSK-3
|
|
BRD0209 is a highly selective and potent GSK3 inhibitor. |
|
T1741 |
AZD1080
|
|
GSK-3
|
|
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. |
