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Search Results for " HL60 "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T60002	DC-S239		Histone Methyltransferase
	DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.		Histone Methyltransferase
T6588	Mitoxantrone	mitozantrone	Topoisomerase , PKC
	Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome...		Topoisomerase , PKC
T0158	Mitoxantrone dihydrochloride	Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride	Topoisomerase , PKC
	Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.		Topoisomerase , PKC
T6018	Zosuquidar trihydrochloride	Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.		P-gp
T12783	RWJ 50271		Integrin
	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).		Integrin
T14946	Ch55	Ch-55,CH 55,3,5-Di-tert-butylchalcone	Retinoid Receptor
	Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.		Retinoid Receptor
T36963	CAY10503
	CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of...
T10973	DC41SMe		Others
	DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used fo...		Others
T60559	S-(N-PhenethylthiocarbaMoyl)-L-cysteine
	S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) is an anticarcinogenic agent. S-(N-PhenethylthiocarbaMoyl)-L-cysteine shows antileukemic activity which inhibits DNA synthesis in HL60 cells [1]. S-(N-Phenethylthiocarb...
T78068	O-allylvanillin		Others
	O-Allylvanillin, an O-allylchalcone derivative, exhibits anti-cancer properties by inhibiting the growth of THP-1, HL60, Hep-G2, and MCF-7 cells with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectivel...		Others
T63957	PI3K-IN-29
	PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 µM, respectively. It effectively blocks the PI3K/Akt sig...
T10971	DC10SMe		Others
	DC10SMe is a DNA alkylating agent that can be used in the synthesis of antibody-drug conjugates (ADC). The IC50 of DC10SMe for Ramos, Namalwa and HL60 / s cancer cells were 15 pM, 12 pM and 12 pM, respectively.		Others
T10975	DC44SMe		Others
	The IC50 of DC44SMe for Ramos, Namalwa and HL60 / s cancer cells was 2.0 nM, 2.8 nM and 1.9 nM, respectively. DC44SMe can be used for targeted treatment of cancer. DC44SMe is a phosphate prodrug of DC44 and can be used i...		Others
T79478	Anti-inflammatory agent 45		Apoptosis
	Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies, such as leukemia, lymphoma, and myeloma cell lines. It induce...		Apoptosis
T10976	DC4SMe		Others
	The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors. DC4SMe is a phosphate prodrug of the cytotoxic DNA alkylati...		Others
T10969	DC1SMe		Others
	DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 ...		Others
T21749	4-iodo-SAHA
	4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM for Skbr3, HT29, U937, JA16, and HL60 cell lines, resp...
T79683	HDAC/CD13-IN-1		Others
	HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM for HDAC1, HDAC2, and HDAC3, respectively. This compound ef...		Others
T78854	WK499
	BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce...

Compounds

DC-S239

T60002

Synonym:

Target: Histone Methyltransferase

Mitoxantrone

T6588

Synonym: mitozantrone

Target: Topoisomerase, PKC

Mitoxantrone dihydrochloride

T0158

Synonym: Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride

Target: Topoisomerase, PKC

Zosuquidar trihydrochloride

T6018

Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Synonym: Ch-55,CH 55,3,5-Di-tert-butylchalcone

Target: Retinoid Receptor

S-(N-PhenethylthiocarbaMoyl)-L-cysteine

Anti-inflammatory agent 45

カタログ番号	製品名	別名	ターゲット
TN6512	Tectol		Transferase , Parasite
	Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti...		Transferase , Parasite
T5S1000	Sophoraflavanone G	Kushenol F,Vexibinol	Apoptosis
	Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.		Apoptosis
T0974	Novobiocin Sodium	Albamycinsodium,Cathomycin,Albamycin	Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T3774	Gracillin		cell cycle arrest
	Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent. Gracillin can be selected as lead compounds for the development of new d...		cell cycle arrest
T2S0357	6-Hydroxycoumarin	6-hydroxychromen-2-one	Others , Carbonic Anhydrase
	6-Hydroxycoumarin (6-hydroxychromen-2-one) exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a human CA9, CA12 inhibitor.		Others , Carbonic Anhydrase
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
T21165	Pellitorine	AI3-19560,Pellitorin	TRP/TRPV Channel
	Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.		TRP/TRPV Channel
T2924	Phloretin	Dihydronaringenin,NSC 407292,RJC 02792	SGLT , transporter , Endogenous Metabolite
	Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav...		SGLT , transporter , Endogenous Metabolite
TN2835	28-Deoxonimbolide		Caspase
	28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells.		Caspase
TN5579	Trigoxyphin A
	Trigoxyphin A exhibits strong cytotoxic activity against HL60 (IC(50): 0.27 microM) and A549 (IC(50): 7.5 microM) tumor cell lines.
T80995	Theasaponin E2
	Theasaponin E2, isolated from Camellia sinensis [1], exhibits cytotoxicity against K562 and HL60 cells with an IC50 of 14.7 μg/mL.
TN2192	Scutebarbatine B		Others
	Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines and HL60 cell lines.		Others
T80996	Theasaponin E1
	Theasaponin E1 is a saponin derived from tea seeds, demonstrating antitumor potential in human tumor cell lines K562 and HL60. Additionally, it possesses quinone reductase (QR)-inducing activity, suggesting its efficacy ...
T1507	Streptozocin	STZ,Streptozotocin,NSC-85998,U 9889	DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy
	Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th...
TN2977	3-O-trans-p-Coumaroyltormentic acid		Caspase , Antifection
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, ...		Caspase , Antifection

天然物製品

Tectol

TN6512

Synonym:

Target: Transferase, Parasite

Sophoraflavanone G

T5S1000

Synonym: Kushenol F,Vexibinol

Target: Apoptosis

Novobiocin Sodium

T0974

Synonym: Albamycinsodium,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Gracillin

T3774

Synonym:

Target: cell cycle arrest

6-Hydroxycoumarin

T2S0357

Synonym: 6-hydroxychromen-2-one

Target: Others, Carbonic Anhydrase

2-Desoxy-4-epi-pulchellin

TN2755

Synonym:

Target: Anti-infection

Pellitorine

T21165

Synonym: AI3-19560,Pellitorin

Target: TRP/TRPV Channel

Phloretin

T2924

Synonym: Dihydronaringenin,NSC 407292,RJC 02792

Target: SGLT, transporter, Endogenous Metabolite

Synonym: STZ,Streptozotocin,NSC-85998,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

3-O-trans-p-Coumaroyltormentic acid

TN2977

Synonym:

Target: Caspase, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-00501	PADI4 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-00502	PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-01238	PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated	Human	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...

PADI4 Protein, Cynomolgus, Recombinant (His)

TMPK-00501

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

TMPK-00502

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

TMPK-01238

Species: Human

Expression System: E. coli