|
TP1616L |
Hsp70-derived octapeptide acetate
|
Hsp70-derived octapeptide acetate(736171-62-3 free base) |
Others
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Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate) is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognat... |
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T3487 |
HSP70-IN-1
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Others
,
HSP
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HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM). |
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TP1616 |
Hsp70-derived octapeptide
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|
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A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing... |
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T74278 |
HSP70-IN-3
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|
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HSP70-IN-3, a potent inhibitor of HSP70 with IC50 values of 1.1 μM in ASZ001 cells and 1.9 μM in C3H10T1/2 cells, exhibits anti-Hedgehog (Hh) signaling and anti-proliferative activities. Furthermore, it reduces the expre... |
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T82167 |
HSP70/SIRT2-IN-2
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HSP
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HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1]. |
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T82168 |
HSP70/SIRT2-IN-1
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Sirtuin
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HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1]. |
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T3293 |
Apoptozole
|
Apoptosis Activator VII |
Apoptosis
,
HSP
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Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis. |
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T8858 |
DTHIB
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HSP
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DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. |
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T1960 |
YL-109
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AhR
,
Aryl Hydrocarbon Receptor
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YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo. |
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T21551 |
2-hexyl-4-Pentynoic Acid
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HDAC
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2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM. |
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T1676 |
Rosuvastatin
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ZD 4522 |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
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Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting... |
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T1510 |
Rosuvastatin calcium
|
ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
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Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
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T3594 |
ML346
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HSP
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ML346 is a novel activator of Hsp70. |
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T5350 |
JG-98
|
JG98,JG 98 |
Apoptosis
,
HSP
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JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM). |
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T7010 |
VER-155008
|
VER155008 |
GPR
,
HSP
,
Autophagy
|
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VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90. |
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T21852 |
AEG 3482
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Apoptosis
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AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent exp... |
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T6210 |
Pifithrin-μ
|
PFTμ,NSC 303580,2-Phenylethynesulfonamide |
HSP
,
p53
,
Autophagy
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Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity. |
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T3515 |
TRC051384 HCl
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HSP
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TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells. |
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T25770 |
116-9e
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MAL-2-11B,MAL2-11B,MAL211B,MAL 2 11B,MAL2 11B |
Virus Protease
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116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediat... |
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T5152 |
MKT-077
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MKT 077,FJ-776,MKT077 |
HSP
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MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular ... |
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T8741 |
MitoBloCK-10
|
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m |
Others
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MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity... |
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TP1496L |
P5 Ligand for Dnak and DnaJ acetate
|
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) |
HSP
|
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p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40). |
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T3527 |
TRC051384
|
TRC 051384 |
HSP
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TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ... |
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T67897 |
GRP78-IN-3
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HSP
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GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of... |
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T70353 |
JG-231
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HSP
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JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negative breast cancer (TNBC).JG-231 inhibits the interaction of Hsp70-BAG3.JG-231 inhibits the MDA-MB-231 ... |
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T14083 |
Abaperidone
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Dopamine Receptor
,
5-HT Receptor
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Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... |
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T2444 |
KNK437
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Heat Shock Protein Inhibitor I |
HSP
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KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40). |
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T26343 |
YK5
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YK 5,YK-5 |
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YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70. |
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T24151 |
HS-72
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HS 72 |
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HS-72 is an allosteric inhibitor. It is also selective for the inducible form of Hsp70. |
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T28357 |
PET-16
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PET16,PET 16 |
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PET-16 is a HSP70 inhibitor. |
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T62519 |
SW02
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SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau). |
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T27184 |
Displurigen
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Displurigen is an inhibitor of ATPase activity of HSP70. |
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T74740 |
JG-258
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JG-258 is an inactive negative control for Hsp70 inhibitors [1] . |
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T38045 |
Cholesterol β-D-Glucoside
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Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in respons... |
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T27655 |
JG-48
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JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells. |
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T73579 |
YM-1
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YM-1, a stable and soluble analog of MKT-077, is an orally active inhibitor of Hsp70 that induces cell death in HeLa cells and elevates the levels of p53 and p21 proteins [1] [2]. |
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T62670 |
Cemdomespib
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Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. cemdomespib induces a heat shock response, induces Hsp70 levels and has neuroprotective effects. cemdomespib has been shown to improve sensory deficits ... |
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T36436 |
Spergualin trihydrochloride
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Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1].
Spergualin trihydrochloride derivatives likely acts as Hsp70 modulato... |
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T80752 |
YM-08
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Sirtuin
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YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1]. |
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T63430 |
Rosuvastatin Sodium
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Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor (IC50: 11 nM) that effectively blocks hERG currents (IC50: 195 nM). Rosuvastatin Sodium reduces the expression of mature hERG and inhibits the inte... |
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T68393 |
SNX-7081
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|
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NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to ... |
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T79013 |
SLMP53-2
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|
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SLMP53-2 is a mutant p53 reactivator that restores the wild-type-like conformation and DNA-binding ability of mutp53-Y220C through enhanced interaction with Hsp70, thereby reinstating p53's transcriptional activity. This... |
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T79487 |
MAO A/HSP90-IN-2
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|
Monoamine Oxidase
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MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phosph... |
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T83890 |
Flavokawain 1i
|
Flavokavain 1i |
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Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties. At a concentration of 30 µM, it suppresses the growth of gefitinib-resistant H1975 ... |
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T36865 |
Heat Shock Protein Inhibitor II
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|
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Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hs... |
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T83785 |
2-Chloroadenosine-5'-O-diphosphate sodium
|
2-chloro ADP |
|
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2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered ... |
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T71110 |
Nanatinostat TFA
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|
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Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inh... |
