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Search Results for " IL-1 γ "

ターゲット

阻害剤

天然化合物

1746

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T72017	6(5H)-Phenanthridinone		Others
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κ...		Others
T38008	KBC-007		Others
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3...		Others
T69671	SR1903 TFA		Others
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec...		Others
T78508	Delmitide acetate	RDP-58 acetate	IFNAR
	Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties. This compound suppresses the production of TNF-α, IFN-γ, and interleukin (IL)-12, while enhancing the ...		IFNAR
T70291	PCC0208018		Others
	PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programm...		Others
T81331	QL-1200186		JAK
	QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following interleukin-12 (IL-12) stimulation and markedly improves skin le...		JAK
T61071	AX-024		Others
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. Wi...		Others
T76945	Cetrelimab
	Cetrelimab (JNJ 63723283; JNJ 3283), a humanized IgG4κ monoclonal antibody (mAb) targeting PD-1, binds to PD-1 (Kd=1.72 nM, HEK293) to prevent its interaction with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, resp...
T35638	SR 1903		Others
	SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al...		Others
T36998	7β,27-dihydroxy Cholesterol	7β,27-DHC,7β,27-dihydroxy Cholesterol	Others
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res...		Others
T83681	IRBP (1-20) (human, rat) TFA	IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20), a dodecapeptide fragment of retinoid-binding protein 3, plays a crucial role in pigment regeneration by facilitating the transport of retinol and retinal bet...
T85077	AKP-11		Others
	AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK ph...		Others
T36486	Benpyrine		Others
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...		Others

Compounds

6(5H)-Phenanthridinone

Synonym: RDP-58 acetate

7β,27-dihydroxy Cholesterol

T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

Target: Others

IRBP (1-20) (human, rat) TFA

T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

カタログ番号	製品名	ターゲット
T37280	PE(18:1(9Z)/0:0)	Endogenous Metabolite
	PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a ...	Endogenous Metabolite
T6S0139	Neobavaisoflavone	Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...	Apoptosis , DNA/RNA Synthesis
T3829	Ginsenoside F3	Others , IFNAR , Interleukin
	Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhances the NF-kappaB DNA binding activity induced by ConA in m...	Others , IFNAR , Interleukin

天然物製品

PE(18:1(9Z)/0:0)

T37280

Synonym:

Target: Endogenous Metabolite

Neobavaisoflavone

T6S0139

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

Ginsenoside F3

T3829

Synonym:

Target: Others, IFNAR, Interleukin

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02926	IL-2RG Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is P31785.
TMPJ-01234	IL-36 gamma Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in b...
TMPJ-00070	IL-18 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The c...
TMPK-00076	IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated	Human	E. coli
	Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop...
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63...
TMPK-00986	IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232...
TMPK-00239	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232...
TMPK-00238	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232...
TMPK-00987	IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232...
TMPY-05692	IL-2RG Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.72 kDa and the accession number is P31785-1.
TMPY-06359	IL-2RG Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 31.53 kDa and the accession number is NP_000197.1.
TMPK-00317	IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00512	IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)	Cynomolgus	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00043	IL-21 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	E. coli
	Interleukin-21 (IL-21), produced predominantly by CD4 T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological process...
TMPK-00316	IL-18R alpha Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell pr...
TMPJ-01337	IL-21R Protein, Mouse, Recombinant (aa 20-236, His)	Mouse	HEK293 Cells
	Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also f...
TMPJ-00177	BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated	Human	HEK293 Cells
	B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-02112	FGFR4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-00322	DEC-205 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp...
TMPY-02779	Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)	Human	Baculovirus Insect Cells
	Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)	Human	HEK293 Cells
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in devel...
TMPY-04529	EGFR Protein, Human, Recombinant (aa 668-1210, His & GST)	Human	Baculovirus Insect Cells
	EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.1 kDa and the accession number is P00533-1.
TMPY-04261	CD64 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD64 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is P12314-1.
TMPY-01147	R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.
TMPY-00464	M-CSF/CSF1 Protein, Mouse, Recombinant	Mouse	HEK293 Cells
	M-CSF/CSF1 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P07141-1.
TMPY-02412	ENO1 Protein, Human, Recombinant (His)	Human	E. coli
	ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1.
TMPY-01920	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin S Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P25774-1.
TMPY-06074	B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is A0A2K5U6P5-1.
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
TMPY-03956	Fas Ligand Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells su...
TMPY-00414	LILRA5/CD85f/ILT11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LILRA5/CD85f/ILT11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is A6NI73-1.
TMPY-01082	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His)	RSV	HEK293 Cells
	Human respiratory syncytial virus (RSV) (A, rsb1734) glycoprotein G/RSV-G Protein (95% Homology) (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession num...
TMPY-06076	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.7 kDa and the accession number is Q8N149-1.
TMPY-03967	BTN3A3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BTN3A3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is O00478-1.
TMPY-02154	FAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FAP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q12884-1.
TMPY-00756	FGF-1 Protein, Human, Recombinant	Human	E. coli
	FGF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is P05230-1.
TMPY-05201	Siglec-2/CD22 Protein, Human, Recombinant	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 75.2 kDa and the accession number is P20273-1.
TMPY-05827	PD-L2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 48.93 kDa and the accession number is Q9BQ51-1.
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
TMPY-05354	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is P10747-1.
TMPY-00820	IgG1 Fc Protein, Human, Recombinant (C103S)	Human	HEK293 Cells
	IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1.
TMPY-02312	CSF3R/G-CSFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CSF3R/G-CSFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q99062-1.
TMPY-05220	TSLP Protein, Human, Recombinant (R127A & R130S, His)	Human	HEK293 Cells
	TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1.
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