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T72322 |
R 59-022 hydrochloride
|
DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride |
5-HT Receptor
,
PKC
|
|
R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R... |
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T11037 |
Diacylglycerol acyltransferase inhibitor-1
|
|
Others
|
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Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1. |
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T16709 |
R 59-022
|
Diacylglycerol kinase inhibitor I,DKGI-I |
Others
|
|
R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits ... |
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T13373 |
YM17E
|
|
Acyltransferase
,
AChR
|
|
|
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T8236 |
RHC 80267
|
U-57908 |
Others
,
Phospholipase
,
COX
,
Acyltransferase
,
AChR
|
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RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets) |
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T12767 |
RP 70676
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|
Acyltransferase
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T15109 |
DGAT1-IN-1
|
|
Transferase
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DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM). |
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T8314 |
RP-64477
|
RP64477 |
Acyltransferase
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RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor. |
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T26019 |
R59949
|
R-59949,R 59949 |
Others
,
PKC
|
|
R59949 is used as a Diacylglycerol kinase (DGK) inhibitor. |
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T9711 |
OGT-IN-2
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Others
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OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1]. |
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T12425 |
PF-06424439 methanesulfonate
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|
Acyltransferase
,
Transferase
|
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PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh... |
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T6937 |
PF-04620110
|
PF04620110,PF 04620110 |
Acyltransferase
,
Transferase
|
|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
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T16409 |
OSMI-1
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|
Others
,
Acyltransferase
|
|
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. |
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T23521 |
VULM 1457
|
|
Acyltransferase
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VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of... |
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T10035 |
10,12-Tricosadiynoic acid
|
TDA,TCDA |
Acyltransferase
|
|
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... |
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T23550 |
YM-750
|
YM 750 |
Acyltransferase
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YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest... |
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T11733 |
K-604 dihydrochloride
|
|
Acyltransferase
|
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K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM. |
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T4681 |
T863
|
DGAT-3,DGAT-1 inhibitor |
Acyltransferase
,
Transferase
|
|
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... |
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T22665 |
PD 128042
|
CI 976 |
Acyltransferase
|
|
PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi... |
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T2753 |
Avasimibe
|
PD-148515,CI-1011 |
P450
,
Acyltransferase
|
|
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
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T15247 |
ESI-05
|
NSC 116966 |
cAMP
|
|
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
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T22726 |
Dioctanoylglycol
|
2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate |
Others
|
|
Dioctanoylglycol (ethane-1,2-diyl dioctanoate) is a diacylglycerol kinase inhibitor. |
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T6365 |
A 922500
|
A922500,DGAT-1 Inhibitor 4a |
Acyltransferase
,
Transferase
|
|
A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. |
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T12225L |
Nevanimibe hydrochloride
|
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis
,
Acyltransferase
|
|
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
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T12426 |
PF-06424439
|
|
Acyltransferase
,
Transferase
|
|
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T14375 |
AZD3988
|
|
Transferase
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AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity. |
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T11827 |
Pradigastat
|
ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase
|
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Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. |
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T73053 |
BAY 2965501
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PERK
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BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer. |
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T10954 |
DAGLβ-IN-1
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Others
|
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DAGLβ-IN-1 is a universal intermediate for designing DAGL tailored activity-based probes, and is an inhibitor of diacylglycerol lipase-β (DAGLβ). |
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T9186 |
Ervogastat
|
PF-06865571 |
Transferase
|
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Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). |
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T11016 |
DGAT-1 inhibitor 2
|
|
Transferase
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DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s... |
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T77761 |
BMS-502
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Others
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BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune respo... |
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T33788 |
Oleoyl glutamic acid
|
NSC 513733,Glutamic acid, N-oleoyl-,NSC-513733,NSC513733 |
|
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Oleoyl glutamic acid is a diacylglycerol analog. |
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T24128 |
H2-005
|
H2 005 |
|
|
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2). |
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T33814 |
OptoDArG
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Opto-DArG,Opto DArG |
|
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OptoDArG is a diacylglycerol (DAG) photoswitch, which enables efficient control of TRPC3 by light. |
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T24127 |
H2-003
|
H2003 |
|
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H2-003 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2). |
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T70160 |
PF-06427878
|
|
|
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PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor. |
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T71105 |
AZD2353
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|
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AZD2353 is a potent inhibitor of diacylglycerol acetyl transferase 1 (DGAT1). |
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T27692 |
JNJ-DGAT2-B
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JNJDGAT2B,JNJ DGAT2 B |
|
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JNJ-DGAT2-B is a selective inhibitor of Diacylglycerol acyltransferase 2. |
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T71755 |
QNN33358
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|
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QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist. |
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T11070L |
DO34
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Others
|
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DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). |
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T27099 |
CU-3
|
CU 3,CU3 |
|
|
CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity. |
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T40972 |
1-Oleoyl-2-acetyl-sn-glycerol
|
|
|
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1-Oleoyl-2-acetyl-sn glycerol, a synthetic, cell-permeable diacylglycerol analog, activates calcium-dependent protein kinase C (PKC) and induces superoxide production. |
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T29275 |
1,3-Didecanoylglycerol
|
1,3-Dicaprin |
|
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1,3-Didecanoylglycerol is a saturated diacylglycerol with decanoic acid (Item No. 20838) at the sn-1 and sn-3 positions. It has been used in the formation of lipid monolayers in the study of lipases. |
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T37044 |
1,2-Dioleoyl-rac-glycerol-13C3
|
1,2-Dioleoyl-rac-glycerol-13C3 |
|
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1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at th... |
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T40757 |
1-Stearoyl-2-arachidonoyl-sn-glycerol
|
|
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1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) encompassing polyunsaturated fatty acids, possesses the ability to activate PKC. Moreover, this compound has the potential to enhance nonselective cation chan... |
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T79826 |
DGKα-IN-6
|
|
|
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DGKα-IN-6, a diacylglycerol kinase alpha (DGKα) inhibitor characterized by an inhibitory concentration (IC50) of 1.377 nM,holds promise for use in cancer research. |
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T35445 |
1-Stearoyl-3-Oleoyl-rac-glycerol
|
|
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1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-... |
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T72929 |
18:0-22:6 DG
|
1-Stearoyl-2-docosahexaenoyl-sn-glycerol |
|
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1-Stearoyl-2-docosahexaenoyl-sn-glycerol (18:0-22:6 DG) is a diacylglycerol capable of binding to RasGRP and modulating the activation of MAP kinases. |
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T74027 |
1-Palmitoyl-2-oleoyl-sn-glycerol
|
|
|
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1-Palmitoyl-2-oleoyl-sn-glycerol, an endogenous metabolite, serves as a predominant diacylglycerol in the hormogonium-inducing factor (HIF)-1 [1]. |
