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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T15079 | DBPR108 | Proteasome , DPP-4 | |
DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9. | |||
T7369 | Gemigliptin | LC15-0444 | Proteasome , DPP-4 |
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.) | |||
T1502 | Vildagliptin | NVP-LAF 237,LAF237 | Apoptosis , Ferroptosis , Proteasome , DPP-4 |
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit... | |||
T0191 | Linagliptin | BI 1356 | Ferroptosis , Proteasome , DPP-4 , Autophagy |
Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. | |||
T4042 | Talabostat mesylate | Val-boroPro,PT100 | Proteasome , DPP-4 |
Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti... | |||
T7369L | Gemigliptin Tartrate(911637-19-9 free base) | LC15-0444 tartrate | Proteasome , DPP-4 |
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit... | |||
TQ0038 | Brensocatib | AZD7986,INS 1007 | Proteasome |
Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively). | |||
T16684 | Puromycin aminonucleoside | NSC 3056 | Apoptosis , Proteasome , Aminopeptidase , Antibacterial , Antibiotic |
Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner. | |||
T0242 | Sitagliptin | MK0431 | Proteasome , DPP-4 , Autophagy |
Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedion... | |||
T11526 | DPP-IV-IN-2 | H-Lys(4-nitro-Z)-pyrrolidide | DPP-4 |
DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM). | |||
T6237 | Trelagliptin | SYR-472 | Proteasome , DPP-4 |
Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor. | |||
T12710 | Retagliptin Phosphate | SP 2086 | Proteasome , DPP-4 |
Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes. | |||
T1674 | Nateglinide | A4166,Senaglinide | Potassium Channel , Proteasome , PPAR |
Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins... | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
T6192 | Alogliptin | SYR-322 | Ferroptosis , Proteasome , DPP-4 |
Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9. | |||
T4467 | UAMC00039 dihydrochloride | UAMC 00039 dihydrochloride | Proteasome |
UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM. | |||
T25340 | Diprotin A | Ile-Pro-Ile | DPP-4 |
Diprotin A (Ile-Pro-Ile) (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor. | |||
T6999 | Teneligliptin hydrobromide | Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide) | Others , Proteasome , DPP-4 |
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 ... | |||
T7133 | Anagliptin | SK-0403 | Proteasome , DPP-4 |
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. | |||
T8550 | NDMC101 | Others , NF-κB , Proteasome | |
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. | |||
T2401 | Alogliptin Benzoate | SYR 322,Alogliptin(SYR-322)benzoate | Ferroptosis , Proteasome , DPP-4 |
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the... | |||
T23358 | Sitagliptin phosphate | Januvia,MK-0431 phosphate,Sitagliptin (phosphate) | DPP-4 , Autophagy |
Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor. | |||
T2296 | Trelagliptin succinate | SYR-472 succinate,SYR472 | Proteasome , DPP-4 |
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D). | |||
T6203 | Saxagliptin | BMS-477118,Onglyza | Proteasome , DPP-4 |
Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. | |||
T0178 | Saxagliptin hydrate | Onglyza hydrate,BMS-477118 hydrate | Proteasome , DPP-4 |
Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM). | |||
T0242L | Sitagliptin phosphate monohydrate | MK-0431,MK-0431 phosphate monohydrate | Proteasome , DPP-4 , Autophagy |
T36583 | Gly-Pro-pNA hydrochloride | Gly-Pro p-nitroanilide hydrochloride | Proteasome |
Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX. | |||
T78410 | Gly-Pro-AMC hydrobromide | Gly-Pro-AMC HCl | |
Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) is a specific fluorescent dye used in cytofluorescence assays to detect Dipeptidyl peptidase IV (DPP-IV) activity. | |||
T67852 | Linagliptin Methyldimer | Proteasome | |
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM. | |||
T29019 | TS-021 | TS021,TS 021,TS-021 Free | DPP-4 |
TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes. | |||
T18997 | GPDA | Glycylproline p-nitroanilide tosylate,GPN | Others |
GPDA (Glycylproline p-nitroanilide tosylate) is a substrate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. | |||
T78223 | γ-Glu-Tyr | gamma-Glutamyltyrosine,gamma-GLU-TYR | |
γ-Glu-Tyr (gamma-Glutamyltyrosine) is a kokumi peptide with competitive inhibition of dipeptidyl peptidase-IV (DPP-IV) and is used in the study of diabetes mellitus. | |||
T68053 | Denagliptin | GW823093 | DPP-4 |
Denagliptin is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor for the treatment of endocrine Ü metabolic diseases and can be used in the study of type 2 diabetes. | |||
T21979 | P32/98 (hemifumarate) | ||
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32... | |||
T27353 | Fotagliptin | ||
Fotagliptin is a dipeptidyl peptidase IV inhibitor. | |||
T11049 | Diprotin A TFA | Ile-Pro-Pro (TFA) | Others |
Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). | |||
T25341 | Diprotin B | ||
Diprotin B is a dipeptidyl peptidase IV inhibitor. | |||
T22886 | K 579 | Others | |
K 579 is a dipeptidyl peptidase IV inhibitor. | |||
T31378 | Denagliptin tosylate | GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093 | |
Denagliptin (GW823093 or GSK-823093) is a dipeptidyl peptidase IV (DPP-IV) inhibitor. | |||
T25382 | Epostatin | ||
Epostatin is a new dipeptidyl peptidase II (DPP-II, EC 3.4.14.2) inhibitor. | |||
T70254 | FE-999011 | ||
FE-999011 is a dipeptidyl peptidase IV inhibitor. | |||
T26850 | BMS-538305 HCl | BMS-538305,BMS538305,BMS 538305,BMS-538305 hydrochloride | |
BMS-538305 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP-IV). | |||
T27598 | Imigliptin Dihydrochloride | Imigliptin | |
Imigliptin Dihydrochloride, a selective dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type II diabetes. | |||
T10082 | DPP-IV-IN-1 | Others | |
DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM). | |||
T30166 | ASP-4000 HCl | ASP4000 HCl,ASP 4000 HCl,UNII-7393JFE67B | |
ASP-4000 HCl is an inhibitor of dipeptidyl peptidase 4 (DPP) with anti-hyperglycemic activity. | |||
T29485 | 7-Lysylalanyl-4-methylcoumarinamide | ||
7-Lysylalanyl-4-methylcoumarinamide is a Fluorogenic substrate for dipeptidyl aminopeptidase. | |||
T23705 | Allo-Ile-isoindoline HCl | TC-E 5007,allo Ile isoindoline HCl,TC-E-5007,TCE5007,TCE 5007 | |
Allo-Ile-isoindoline HCl is an irreversible and selective inhibitor of dipeptidyl peptidase 8 and 9. | |||
T26941 | Camegliptin | RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579 | |
Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes. | |||
T11450 | Gosogliptin | PF-00734200,PF-734200 | Others |
T71117 | AZD5248 | ||
AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1). |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T16838 | Saikogenin A | Proteasome , DPP-4 | |
Saikogenin A is a dipeptidyl peptidase-4 inhibitor. | |||
TN1418 | Azaleatin | DPP-4 | |
Azaleatin is a natural product from Rhododendron simsii. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for type-2 diabetes and obesity studies. | |||
T75493 | Ellipyrone B | ||
Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 =0.48 mM) [1]. | |||
T39219 | Ficusonolide | ||
Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase. | |||
T75492 | Ellipyrone A | ||
Ellipyrone A, a γ-pyrone-based macrocyclic polyketide, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 = 0.35 mM). Additionally, this compound exhibits anti-glycolytic effects on α-glucosidase (IC ... | |||
T83863 | Fluostatin A sodium | ||
Fluostatin A, a fluorenone compound initially isolated from Streptomyces, demonstrates selective inhibition towards dipeptidyl peptidase 3 (DPP-3) compared to DPP-1, DPP-2, and DPP-4 with IC50 values of 0.44 µg/ml for DP... | |||
T81898 | Lyciumamide A | ||
DPP-IV-IN-5, derived from Lycium barbarum fruits, demonstrates moderate agonistic activity towards peroxisome proliferator-activated receptor (PPARγ), showing EC50 values between 10.09 and 44.26 μM, and exhibits inhibito... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-01358 | DPP3 Protein, Human, Recombinant (His) | Human | E. coli |
Dipeptidyl peptidase 3(DPP3), is a member of the S9B family in clan SC of the serine proteases. DPP3 has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. This c... | |||
TMPH-02628 | Cathepsin C Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function. | |||
TMPH-03279 | DPP4/CD26 Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli |
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, ... | |||
TMPY-02737 | DPP2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
DPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9ET221. | |||
TMPH-00067 | Venom dipeptidyl peptidase 4 Protein, Apis mellifera, Recombinant (His & Myc) | Apis mellifera | E. coli |
Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process promelittin into its active form ... | |||
TMPY-00777 | DPP2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
DPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q9UHL4. | |||
TMPY-01854 | DPP10 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein w... | |||
TMPK-00383 | ACE2/ACEH Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPK-00377 | DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells |
CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metast... | |||
TMPK-00552 | ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated | Cynomolgus | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPK-00382 | ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPK-00551 | ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi) | Cynomolgus | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPY-02070 | Cystatin SN Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cystatin-SN, also known as Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1 and CST1, is a secreted protein which belongs to thecystatin family. The cystatin superfamily encompasses proteins that contain multiple cyst... | |||
TMPY-00732 | Cathepsin C Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno... | |||
TMPY-06885 | SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His) | ||
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... |