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カタログ番号	製品名	別名	ターゲット
T8395	Nomegestrol acetate		Others , Progesterone Receptor
	Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor		Others , Progesterone Receptor
T28362	PF-02413873	PF02413873	Progesterone Receptor
	PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.		Progesterone Receptor
T2567	Etonogestrel	3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T13703	Gestonorone Capronate		Prostaglandin Receptor
	Gestonorone Capronate is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer.		Prostaglandin Receptor
T2357	GSK1059615	GSK 1059615,GSK-1059615	Apoptosis , PI3K , mTOR
	GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.		Apoptosis , PI3K , mTOR
T61864	Melengestrol acetate		Progesterone Receptor
	Melengestrol acetate is a derivative of progesterone and acts as a corticosteroid hormone. Melengestrol acetate promotes endometrial proliferation delay of menstrual activity and pregnancy maintenance.		Progesterone Receptor
T11146	EC359	EC-359	Apoptosis , Others
			Apoptosis , Others
T76749	Zilovertamab	Cirmtuzumab,UC-961	Others
	Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity in ovarian and endometrial cancer cells. It can be used to s...		Others
T1916	Apitolisib	RG 7422,GNE 390,GDC-0980	Apoptosis , PI3K , mTOR
	Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...		Apoptosis , PI3K , mTOR
T2527	Ulipristal acetate	Ulipristal,CDB-2914	Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy
	Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb...
T20755	Trimegestone	RU27987,RU-27987,RU 27987
	Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.
T61212	Steroid sulfatase-IN-2
	Steroid sulfatase-IN-2 is an active inhibitor of steroid sulfatase (STS), demonstrating an IC50 value of 109.5 nM. Its potential application lies in hormone-dependent cancer research, specifically estrogen-dependent brea...
T36968	ARN-21934		Topoisomerase
	ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...		Topoisomerase
T5317L	Cridanimod sodium	XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101
	Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, ca...
T72390	Estradiol hemihydrate	17β-Oestradiol hemihydrate,β-Estradiol hemihydrate ; 17β-Estradiol hemihydrate ; 17β-Oestradiol hemihydrate,17β-Estradiol hemihydrate,β-Estradiol hemihydrate
	Estradiol (β-Estradiol) hemihydrate, a key female sex hormone and steroid, plays a significant role in up-regulating neural markers in human endometrial stem cells (hEnSCs) and facilitating their neural differentiation. ...
T60854	ENMD-1068 hydrochloride
	ENMD-1068 hydrochloride, a selective protease-activated receptor 2 (PAR2) antagonist, inhibits TGF-β1/Smad signaling, thereby reducing hepatic stellate cell activation and collagen expression. It also suppresses the prol...
T71218	AEZS-112
	AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cyto...
T70775	Zoptarelin doxorubicin
	Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibio...
T74415	Imlunestrant tosylate
	Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent...
T36913	17-Epiestriol
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding af...

Compounds

Nomegestrol acetate

T8395

Synonym:

Target: Others, Progesterone Receptor

PF-02413873

T28362

Synonym: PF02413873

Target: Progesterone Receptor

Etonogestrel

T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Gestonorone Capronate

T13703

Synonym:

Target: Prostaglandin Receptor

GSK1059615

T2357

Synonym: GSK 1059615,GSK-1059615

Target: Apoptosis, PI3K, mTOR

Melengestrol acetate

T61864

Synonym:

Target: Progesterone Receptor

EC359

T11146

Synonym: EC-359

Target: Apoptosis, Others

Zilovertamab

T76749

Synonym: Cirmtuzumab,UC-961

Target: Others

Apitolisib

T1916

Synonym: RG 7422,GNE 390,GDC-0980

Target: Apoptosis, PI3K, mTOR

Ulipristal acetate

T2527

Synonym: Ulipristal,CDB-2914

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy

Trimegestone

T20755

Synonym: RU27987,RU-27987,RU 27987

Target:

Steroid sulfatase-IN-2

Target: Topoisomerase

Cridanimod sodium

T5317L

Synonym: XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101

Target:

Estradiol hemihydrate

T72390

Synonym: 17β-Oestradiol hemihydrate,β-Estradiol hemihydrate ; 17β-Estradiol hemihydrate ; 17β-Oestradiol hemihydrate,17β-Estradiol hemihydrate,β-Estradiol hemihydrate

Target:

ENMD-1068 hydrochloride

Zoptarelin doxorubicin

T70775

Synonym:

Target:

Imlunestrant tosylate

カタログ番号	製品名	別名	ターゲット
T1048	Estradiol	E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be...
T1284	Megestrol acetate	SC10363,BDH1298	Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , HIV Protease , Autophagy
	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment ...
T1261	Medroxyprogesterone Acetate	Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate)	Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite
	Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been...
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
TN2400	Alpha-Terthienylmethanol		Others
	Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.		Others
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 ...
T79971	Asparanin A		Apoptosis
	Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It effectively inhibits cancer cell proliferation and has show...		Apoptosis

天然物製品

Estradiol

T1048

Synonym: E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Megestrol acetate

T1284

Synonym: SC10363,BDH1298

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, HIV Protease, Autophagy

Medroxyprogesterone Acetate

T1261

Synonym: Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate)

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, Endogenous Metabolite

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

alpha-Terthienylmethanol

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00238	Lefty-A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma...
TMPK-00649	CDH6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Cadherin 6 (CDH6) is an adhesion molecule localizing to the endometrial luminal epithelial cell surface in the mid-secretory/receptive phase and knockdown of CDH6 in the Ishikawa cells (receptive endometrial epithelial c...
TMPJ-01192	ELAPOR1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated wi...
TMPH-02885	SOSTDC1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, ...
TMPH-03367	SOSTDC1 Protein, Rat, Recombinant (His & Myc)	Rat	HEK293 Cells
	Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt s...
TMPY-00990	Lefty-A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamil...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPJ-01358	DPP3 Protein, Human, Recombinant (His)	Human	E. coli
	Dipeptidyl peptidase 3(DPP3), is a member of the S9B family in clan SC of the serine proteases. DPP3 has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. This c...
TMPJ-00762	ER alpha Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPY-06821	THRB Protein, Human, Recombinant (His)	Human	E. coli
	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-bin...