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TP1174 |
Endothelin-2 (49-69), human
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Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine) |
Others
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Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. |
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T19309L1 |
Endothelin 1 (swine, human) acetate
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Endothelin 1 (swine, human) acetate(117399-94-7 free base) |
Endothelin Receptor
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Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor and acts through two types of receptors ETA and ETB. |
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T22540L |
Ac-Endothelin-1 (16-21), human acetate
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Others
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Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i... |
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TP1175 |
Endothelin-3, human, mouse, rabbit, rat
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Endothelin 3 (Rat,Human) |
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Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor. |
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TP2143 |
Endothelin-2 (49-69), human TFA
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Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA |
Others
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Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB. |
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T36480 |
Big Endothelin-1 (1-39), porcine
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The big endothelins comprise residues 53-90 (human big ET-1) and 53-91 (porcine big ET-1) of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (ET-1), both peptides show less vasoconstricto... |
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TP2099 |
[Ala1,3,11,15]-Endothelin
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Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively). |
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TP1173 |
Endothelin 3 (Rat,Human) (TFA)
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Endothelin-3, human, mouse, rabbit, rat TFA |
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Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that specifically interacts with G-protein-linked transmembrane receptors, ET-RA and ET-RB. |
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T19309 |
Endothelin 1 (swine, human)
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Others
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Endothelin 1 (swine, human), a synthetic peptide mirroring the sequence of both human and swine Endothelin 1, functions as a robust endogenous vasoconstrictor by interacting with two receptor types, ETA and ETB. |
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T22540 |
Ac-Endothelin-1 (16-21), human
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Others
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ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which is a highly cons... |
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TP1512 |
[Ala1,3,11,15]-Endothelin TFA
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[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for ... |
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TP2246 |
Endothelin-1 (1-15), amide, human
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Others
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Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC. |
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T36479 |
Big Endothelin-1 (1-38), human
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Human Big ET-1 comprises residues 53-90 of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (hET-1), the peptide show less vasoconstrictor activity in vitro, but similar pressor effects in... |
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T76329 |
[Asn18] Endothelin-1, human
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[Asn18] Endothelin-1, human, a peptide, represents a predominant isoform of Endothelin, significantly contributing to the regulation of vascular function [1]. |
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T76305 |
[Ala2] Endothelin-3, human
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[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3), characterized by the substitution of Ala for Cys residues. ET-3, a vasoactive peptide produced by human rhabdomyosarcoma cell lines but not expressed ... |
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T15232 |
TBC3711
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Endothelin Mordulator 1 |
Others
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TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders. |
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T78063 |
Endothelin-1 (1-31) (Human) TFA
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ERK
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Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1]. |
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T75731 |
Endothelin 1 (swine, human) (TFA)
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Endothelin 1 (swine, human) (TFA) is a synthetic peptide mirroring the sequence of the potent endogenous vasoconstrictor found in both human and swine Endothelin 1. It operates via two receptor types, ET A and ET B [1]. |
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T76564 |
Endothelin-1 (1-31) (Human)
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Endothelin-1 (1-31) (Human) is a powerful vasoconstrictor and agent for inducing hypertension, originating from the specific hydrolysis of big ET-1 by chymase [1]. |
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T76564L |
Endothelin-1 (1-31) (Human) acetate
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Endothelin-1 (1-31) (Human) acetate, a potent vasoconstrictor and hypertensive agent, is produced through the selective hydrolysis of big ET-1 by chymase [1]. |
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T82886 |
Big endothelin-1 (rat 1-39)
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Big endothelin-1 (rat 1-39), a 39-residue peptide, induces a diuretic and natriuretic response in conscious Sprague-Dawley rats and elevates blood pressure in mice [1]. |
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T5458 |
Darusentan
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Lu-135252 |
Endothelin Receptor
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Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries |
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T2561 |
Macitentan
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ACT-064992 |
Apoptosis
,
Endothelin Receptor
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Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). |
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T76081 |
Endothelin 1 (swine, human), Alexa Fluor 488-labeled
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Endothelin 1 (swine, human), Alexa Fluor 488-labeled, is a synthetic peptide corresponding to the sequence of human and swine Endothelin 1, a powerful endogenous vasoconstrictor, and is tagged with Alexa Fluor 488 for fl... |
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T75772 |
[Ala1,3,11,15]-Endothelin (53-63) (TFA)
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[Ala1,3,11,15]-Endothelin (53-63) (TFA) is a selective ET B agonist with IC50 values ranging from 0.33 nM to 0.61 nM, demonstrating its preference for ET B receptors. It is utilized in the study of vasoconstriction. |
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T3194 |
Ro 46-2005
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Endothelin Receptor
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Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM). |
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T3474 |
RO 46-8443
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Endothelin Receptor
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RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. |
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T6792 |
BQ-123
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BQ123 |
Endothelin Receptor
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BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
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T6264 |
Bosentan
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Actelion,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor
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Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... |
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TQ0282 |
Avosentan
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SPP-301,Ro 67-0565 |
Endothelin Receptor
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Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor). |
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T5355 |
Sparsentan
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RE-021,DARA-a |
RAAS
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Endothelin Receptor
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Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively) |
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T0750 |
Sulfisoxazole
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NU-445,Sulfafurazole |
Endothelin Receptor
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Antibacterial
,
Antibiotic
,
Autophagy
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Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ... |
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T6258 |
Zibotentan
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ZD4054 |
Apoptosis
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Endothelin Receptor
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Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. |
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T2026 |
CYM5442
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S1P Receptor
,
LPL Receptor
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CYM5442 is an S1P agonist, targeting to Sphingosine. |
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T1655 |
Ambrisentan
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BSF-208075,BSF 208075,LU 208075 |
Endothelin Receptor
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Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha... |
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T6265 |
Bosentan (hydrate)
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Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 |
Endothelin Receptor
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Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. |
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TQ0259 |
Atrasentan
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A-147627,(+)-A 127722,ABT-627 |
Endothelin Receptor
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Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA). |
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T6672 |
Sitaxsentan sodium
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TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium |
Endothelin Receptor
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Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors. |
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T7817 |
Aprocitentan
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ACT-132577 |
Endothelin Receptor
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Aprocitentan (ACT-132577) is ETA and ETB antagonist . |
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TQ0270 |
Atrasentan hydrochloride
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(+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride |
Endothelin Receptor
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T15596 |
IRL 2500
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Endothelin Receptor
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IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor. |
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T12924 |
Sitaxsentan
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TBC-11251,IPI 1040 |
Endothelin Receptor
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Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful ef... |
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T31605 |
Edonentan
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BMS207940,BMS-207940,BMS 207940 |
Endothelin Receptor
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Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure. |
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TP2262L |
IRL-1038 acetate
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IRL-1038 acetate(144602-02-8 Free base) |
Endothelin Receptor
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IRL-1038 acetate is a potent ETB endothelin receptor antagonist. |
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T21790 |
BMS 182874 hydrochloride
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Endothelin Receptor
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BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. |
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T7391 |
SAR407899
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ROCK
,
Rho
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SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
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T14219 |
Aminaftone
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Aminaphthone |
Endothelin Receptor
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Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis. |
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TP1220L |
Carperitide acetate
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Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate |
Endothelin Receptor
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Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compou... |
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T34541 |
SB-209670
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SB 209670 |
Endothelin Receptor
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SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle. |
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T15595L |
IRL-1620 acetate
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IRL-1620 acetate（142569-99-1 free base） |
Endothelin Receptor
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IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM. |
