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T82221 |
Head activator neuropeptide
|
|
|
|
Head activator neuropeptide, a mitogen for neuronal or neuroendocrine mammalian cell lines, induces mitosis by signaling through GPR37 binding [1]. |
|
T7459 |
Abametapir
|
HA-44,BRN 0123183 |
MMP
,
Others
,
Parasite
|
|
Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development. |
|
T26889 |
Borofalan(10B)
|
L-4-Boronophenylalanine |
Others
|
|
Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer. |
|
TP1114L |
Leucokinin VIII acetate
|
Leucokinin 8 |
Others
|
|
Leucokinin VIII acetate (Leucokinin 8) is an diuretic octapeptide isolated form head extracts of the cockroach. |
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T17035 |
Temoporfin
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Others
|
|
Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. |
|
T25284 |
DAC-2-25
|
DAC 225,DAC-225,DAC 2 25 |
Others
|
|
DAC-2-25 is a Hydra head regeneration modulator. It acts by inducing a homeotic transformation in Hydra. |
|
T5330 |
Fluralaner
|
AH252723,A1443 |
GABA Receptor
,
Parasite
|
|
Fluralaner (A1443) is an isoxazoline ectoparasiticide. It potently and selectively inhibits binding of the GABA receptor channel blocker EBOB to housefly head membranes (IC50: 455 pM). |
|
T10337 |
Antimicrobial Compound 1
|
|
Antibacterial
|
|
Antimicrobial Compound 1 is an alkyl pyridinium compound with Tail 12C, Head 4-carboxyl. Antimicrobial Compound 1 exhibits antimicrobial activities against B. subtilis and E. coli. |
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T76696 |
Onvatilimab
|
JNJ-61610588 |
Others
|
|
Onvatilimab (JNJ-61610588) is a human IgG1 κ-anti-Vista (T-cell-activated V-domain Ig inhibitor) monoclonal antibody. Onvatilimab has antitumor activity and can be used to treat advanced head and neck cancers. |
|
T2618 |
LGK974
|
LGK 974,LGK-974,NVP-LGK974,WNT974 |
Porcupine
|
|
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel... |
|
T0790 |
Carbaryl
|
1-naphthyl methylcarbamate,Sevin |
AChR
|
|
Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly l... |
|
T77423 |
Lirilumab
|
ONO-4483,IPH2102 |
Virus Protease
|
|
Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-depende... |
|
T76890 |
Petosemtamab
|
MCLA 158 |
EGFR
|
|
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab... |
|
T25683 |
Leucomyosuppressin
|
p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2 |
|
|
Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction. |
|
T71912 |
PD 173955-Analog1
|
|
|
|
PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma. |
|
T29965 |
Amethopterin
|
DL-Amethopterin |
|
|
Amethopterin is a chemotherapy drug and immune system inhibitor used to treat cancers of the blood, bone, lung, breast, head, and neck. In addition, it can treat rheumatoid arthritis and psoriasis. |
|
T20688 |
Leucokinin I
|
|
|
|
Leucokinin I is an eight amino acid neuropeptide. It is found in the nervous system of the bowfly and isolated from the head of Madeira cockroach Leucophaea maderae. |
|
TP1114 |
Leucokinin VIII
|
Leucokinin 8 |
|
|
Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach. |
|
T21119 |
Cevimeline
|
AF-102B,FKS 508,SNI 2011,HSDB 7286 |
|
|
Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase saliv... |
|
T69857 |
DB293
|
|
|
|
DB293 is an inhibitor of PIT-1 and BRN-3 transcription factors. DB293 binds as head-to-tail stacked dimers in the minor groove of 5'-ATGA sequence, thereby leading to an increase in the size of minor groove. |
|
T19377 |
Ioxilan
|
|
Others
|
|
|
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T74742 |
TRPV1 activator-2
|
|
|
|
TRPV1 activator-2 (Compound 9), a capsaicin head analog, engages in targeted interactions with channel residues at the lipid-water interface [1]. |
|
T76918 |
Barecetamab
|
|
|
|
Barecetamab (ISU-104), a fully human anti-ErbB3 monoclonal antibody, is utilized in researching recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) [1]. |
|
T79506 |
Topoisomerase II inhibitor 15
|
|
Topoisomerase
|
|
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1]. |
|
T74288 |
SQDG
|
|
|
|
SQDG, a membrane glycolipid characterized by sugar moieties in its head groups, is instrumental in studying the influence of structural lipids in LNP formulations [1]. |
|
T83423 |
1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine
|
|
|
|
1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine, featuring a phosphatidylethanolamine head group, serves as a fluorescent probe to assess surface lipid oxidation in lipoproteins and plasma [1]. |
|
T77269 |
C13-113-tetra-tail
|
|
|
|
C13-113-tetra tail, a cationic lipid-like compound, features a polar amino alcohol head group, a tertiary amine linker, and four hydrophobic carbon-13 tails. It can be formulated into a lipid nanoparticle (LNP). |
|
T77266 |
C13-112-tri-tail
|
|
|
|
C13-112-tri-tail, a cationic lipid-like compound, features a polar amino alcohol head group, three hydrophobic 13-carbon tails, and a PEG2 linker, allowing for formulation into lipid nanoparticles (LNP). |
|
T21964 |
KP372-1
|
|
|
|
KP372-1 is an Akt inhibitor which block signalling through the PI3K pathway. KP372-1 inhibit cell proliferation while inducing apoptosis and anoikis in squamous cell carcinoma of the head and neck. |
|
T77268 |
C13-112-tetra-tail
|
|
|
|
C13-112-tetra-tail, a cationic lipid-like compound, features a polar amino alcohol head group, four hydrophobic C13 tails, and a PEG2 linker, making it suitable for formulation into lipid nanoparticles (LNPs). |
|
T77267 |
C13-113-tri-tail
|
|
|
|
C13-113-tri tail, a cationic lipid-like compound, features a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. It is capable of being formulated into a lipid nanoparticle (LN... |
|
T28494 |
R-82913
|
NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib |
|
|
R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 ... |
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T76372 |
TRAF6 peptide
|
|
|
|
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS... |
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T35907 |
Paraherquamide A
|
|
|
|
Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A i... |
|
T78221 |
TRAF6 peptide TFA
|
|
E1/E2/E3 Enzyme
|
|
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde... |
|
T82188 |
HN-1
|
|
|
|
HN-1, a 12-mer peptide with specificity for head and neck squamous cell carcinoma (HNSCC), penetrates tumor tissue and facilitates the translocation of agents across cell membranes [1]. |
|
T71491 |
Enadoline (Free Base)
|
|
|
|
Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions... |
|
T62790 |
JH-XIV-68-3
|
|
|
|
JH-XIV-68-3 is a selective inhibitor of the DYRK1A/B macrocycle.JH-XIV-68-3 selectively acts on DYRK1A and its close relative DYRK1B in biochemical and cellular assays.JH-XIV-68-3 has antitumor effects in head and neck s... |
|
T68297 |
Dilmapimod tosylate
|
|
|
|
Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory dist... |
|
T71211 |
Rizatriptan-d6 benzoate salt
|
|
|
|
Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin
receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-H... |
|
T68661 |
Edatrexate
|
CGP 30694 |
|
|
Edatrexate (CGP 30694), also known as 10-Ethyl-10-deazaaminopterin, is an analog of Methotrexate that demonstrates antitumor activity against Methotrexate-resistant tumors. This antifolate antimetabolite is utilized in r... |
|
T35810 |
C24 dihydro Ceramide (d18:0/24:0)
|
Cer(d18:0/24:0) |
|
|
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c... |
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T37217 |
N-Decanoyl p-Nitroaniline
|
|
|
|
N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a var... |
|
T36368 |
2H-Cho-Arg (trifluoroacetate salt)
|
|
|
|
2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and dec... |
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T36350 |
Cho-Arg (trifluoroacetate salt)
|
|
|
|
Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assa... |
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T74566 |
Phospholipid-PEG-Biotin (MW 5000)
|
|
|
|
Phospholipid-PEG-Biotin (MW 5000), a derivative of phospholipid PEG, serves to modify the surfaces of liposomes, cells, and pancreatic islets for cell transplantation. This compound incorporates a phospholipid (a lipid f... |
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T74564 |
Phospholipid-PEG-Biotin (MW 2000)
|
|
|
|
Phospholipid-PEG-Biotin (MW 2000), a biotin-labeled phospholipid PEG derivative, is designed for modifying the surfaces of liposomes, cells, and pancreatic islets intended for cell transplantation. This compound integrat... |
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T72776 |
NR2F1 agonist 1
|
|
|
|
NR2F1 agonist 1, a specific nuclear receptor NR2F1 activator, initiates dormancy programs in cancer cells by upregulating NR2F1 and its target genes controlling dormancy. This compound promotes neural crest-like features... |
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T63556 |
EGFR-IN-59
|
|
|
|
EGFR-IN-59 is an EGFR inhibitor with an IC50 value of 190 nM and an all-time apoptosis inducer. EGFR-IN-59 exhibited cytotoxicity against a non-small lung cancer cell line (A549) and normal lung fibroblasts (WI38) with I... |
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T36359 |
Dios-Arg (trifluoroacetate salt)
|
|
|
|
Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay... |
