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T11281L |
FGI-106 tetrahydrochloride
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Virus Protease
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HCV Protease
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Influenza Virus
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HIV Protease
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T25701 |
Levosemotiadil
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SD 3212,SA 3212 |
LDL
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Calcium Channel
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Levosemotiadil（SA 3212） is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias. |
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T9575 |
MRTX9768
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Histone Methyltransferase
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MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
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T8970 |
ML162
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Ferroptosis
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GPX
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Glutathione Peroxidase
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ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively) |
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T26240 |
Surfen dihydrochloride
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Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl |
FGFR
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Antiviral
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Antibiotic
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Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a potent small molecule antagonist of heparin sulphate with antimicrobial and antiviral activity and inhibits anthrax lethal factor, coagulation factor X and let... |
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T77423 |
Lirilumab
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ONO-4483,IPH2102 |
Virus Protease
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Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-depende... |
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T77520 |
AOH1996
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Apoptosis
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DNA/RNA Synthesis
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AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ... |
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T33050 |
Lysine butyrate
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Lysine butyrate protects against lethal effect of encelphalomyocariditis virus in mice. |
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T81948 |
Latartoxin-1a
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LtTx-1a |
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Latartoxin-1a (LtTx-1a), a paralytic and lethal peptide toxin for insects with membrane-bound activity [1], can be isolated from L. tarabaevi. |
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TP2108 |
TAPI 2
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ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes. |
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T37007 |
Resistoflavine
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Resistoflavine is a metabolite of the marine actinomycete S. chibaensis. It slows the growth of and is cytotoxic to HMO2 and HepG2 cells with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/ml, respectively. |
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T36630 |
MRTX9768 hydrochloride
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MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1].
MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... |
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T60639 |
SLEC-11
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SLEC-11 emerged as a synthetic lethal(SL) lead in E-cadherin-deficient cells which has potential for the treatment of gastric cancer. |
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T35756 |
Avermectin B1a monosaccharide
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Avermectin B1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a monosaccharide al... |
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T62683 |
PRMT5-IN-3
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PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells. |
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T62627 |
Antibacterial agent 69
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Antibacterial agent 69 is a novel structural antimicrobial modulator that can be used against lethal multidrug-resistant bacterial infections (MIC: 2.978 μM). |
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T38259 |
Phenelfamycin E
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Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) inc... |
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T37254 |
Rugulotrosin A
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Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5... |
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T81926 |
LiTx3
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LiTx3, a lethal, cysteine-rich peptide extracted from Loxosceles intermedia crude venom, induces flaccid paralysis in Spodoptera frugiperda larvae [1]. |
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T61815 |
AL-GDa62
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AL-GDa62, a potential synthetic lethal agent for gastric cancer treatment, demonstrates efficacy with EC50 values of 3.2 μM in MCF10A-WT (wild-type) isogenic mammary epithelial cells and 2 μM in MCF10A-CDH1 -/- cells [1]... |
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T61580 |
Autophagy inducer 3
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Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal aut... |
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T25365 |
EGA
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Others
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EGA inhibits the intoxication of lethal toxins and prevents the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells.EGA is a powerful tool for the study of membrane trafficking an... |
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T35521 |
Aflatoxin G2-13C17
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Aflatoxin G2-13C17 |
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Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/... |
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T37680 |
3-hydroxy Palmitic Acid methyl ester
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3-hydroxy Palmitic acid methyl ester (3-hydroxy PAME) is an esterized long-chain fatty acid involved in quorum sensing in R. solanacearum, a bacteria that causes lethal wilting in plants. 3-hydroxy-PAME (175 nM) increase... |
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T78561 |
M62812 free base
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M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1]. |
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T83699 |
LL-37 (18-37) (human) TFA
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KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39 |
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LL-37 (18-37), an antimicrobial peptide fragment of LL-37, exhibits activity against S. aureus and C. albicans, with minimum lethal concentrations of 4 µM and 10 µM, respectively. Additionally, it inhibits E. histolytica... |
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T60419 |
Cyclic HPMPC
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Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcom... |
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T62907 |
TAS-117 hydrochloride
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TAS-117 hydrochloride is a selective, potent, orally active allosteric Akt inhibitor, acting on Akt1 (IC50: 4.8 nM), Akt2 (IC50: 1.6 nM) and Akt3 (IC50: 44 nM). TAS-117 hydrochloride stimulates anti-myeloma activity, enh... |
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T80780 |
W-Conotoxin SVIB
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ω-Conotoxin SVIB, a peptide toxin derived from Conus venoms, exhibits inhibition of the twitch response with an IC50 value of 37 nM and can induce respiratory distress. At high concentrations, it has been shown to be let... |
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T77973 |
YD23
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PROTACs
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YD23 is a SMARCA2 PROTAC that promotes SMARCA2 degradation, a process synthetically lethal to SMARCA4-deficient cells. It specifically diminishes chromatin accessibility at enhancers of various genes involved in cell cyc... |
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T63314 |
Antifungal agent 31
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Antifungal agent 31 is an orally active, triazole antifungal agent possessing a pyrrolizinone scaffold that exhibits some antifungal activity against Candida and filamentous fungi.Antifungal agent 31 significantly reduce... |
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T35513 |
13C15-Nivalenol
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13C15-Nivalenol |
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13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/k... |
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T27647 |
J-104132
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L753037,L 753037,J104132,J 104132,L-753037 |
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J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inosito... |
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T73652 |
Eritoran
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Eritoran, a Toll-like receptor 4 (TLR4) antagonist, effectively protects mice from lethal infections caused by viruses such as the Ebola virus (EBOV) and Marburg virus (MARV). By decreasing granulocytosis levels, Eritora... |
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T78938 |
H3B-968
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DNA/RNA Synthesis
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H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal acti... |
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T63945 |
Antitubercular agent-19
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Antitubercular agent-19 is an antitubercular agent. antitubercular agent-19 showed good antitubercular effects against MTB H37Rv and MDR-MTB (MIC <0.016 μg/ml). antitubercular agent-19 showed low cytotoxicity and relativ... |
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T73183 |
SMYD3-IN-2
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SMYD3-IN-2, a potent inhibitor of SMYD3, demonstrates significant efficacy in combating gastric cancer by promoting lethal autophagy. It exhibits strong inhibitory activity against both SMYD3 and BGC823 cells, with IC 50... |
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T80279 |
Urumin
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Influenza Virus
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Urumin, a compound with antiviral properties, inhibits human influenza A virus growth, particularly the PR8 strain, with an inhibitory concentration (IC 50) of 3.8 μM. It acts by targeting the conserved stalk of H1 hemag... |
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T64640 |
Melanin probe-2
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Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-pi... |
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T36049 |
Linearmycin B
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Linearmycin B is a polyene antibiotic that has been found inStreptomyces.1It induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2
1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linea... |
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T71055 |
Albendazole-d7
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Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helmi... |
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T36349 |
CGP 74514 dihydrochloride
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Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.
Yu et al (2013) The lethal effects of pharmacological cyclin-... |
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T71252 |
PC-046
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PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... |
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T71966 |
PD-128763
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PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enz... |
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T35453 |
β-Defensin-4 (human) (trifluoroacetate salt)
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β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at... |
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T35520 |
Aflatoxin G1-13C17
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Aflatoxin G1-13C17 |
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Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to duckli... |
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T36048 |
Linearmycin A
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Linearmycin A is a polyene antibiotic that has been found inStreptomyces.1It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 μg/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 an... |
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T36055 |
Nitisinone-13C6
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Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyr... |
