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T21632 |
Myoseverin
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Others
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Microtubule Associated
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Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str... |
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T20759 |
XRP44X
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XRP-44-X,XRP 44X,XRP-44X,XRP 44 X |
Ras
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XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. |
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T13688 |
Eribulin
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B1939,ER-086526,E7389 |
Others
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Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. |
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T13807 |
OSIP-486823
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CP248 |
Microtubule Associated
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PKA
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OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules. |
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T6075 |
Epothilone B
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Patupilone,EPO 906 |
Apoptosis
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Microtubule Associated
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Antibiotic
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Antifungal
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Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditi... |
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T13687 |
Eribulin mesylate
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B1939 mesylate,ER-086526 mesylate,E7389 mesylate |
Apoptosis
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Others
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Microtubule Associated
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Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is... |
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T70407 |
Cemadotin free base
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LU103793 free base |
Microtubule Associated
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Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Ce... |
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T15713 |
Larotaxel
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XRP9881 |
P-gp
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Larotaxel (XRP9881) is a taxane analogue that has anticancer activity, exerts its cytotoxic effects by promoting tubulin assembly and stabilizing microtubules, and ultimately induces cell death through apoptosis. Larotax... |
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T28886 |
Suprafenacine
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N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide |
Microtubule Associated
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Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine ... |
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T71278 |
IBPR002
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IBPR002 is an aurora kinase inhibitor which reveals mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. |
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T36364 |
Flutax-2
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Green fluorescent taxol derivative. Used for microtubule imaging. Binds microtubules with high affinity (Ka ~ 107M-1). Excitation/emission maximum λ ~ 496/526 nm.
Lillo et al (2002) Location and properties of the Tax. bi... |
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T31389 |
Desmethyl-HD-800
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Desmethyl-HD800,Desmethyl HD800 |
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Desmethyl-HD-800 is a PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules. |
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T72503 |
Antitubulin agent 1
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Antitubulin Agents-1, an antitubulin agent, disrupts microtubules (Microtubule/Tubulin) and enhances α-tubulin acetylation, exhibiting anticancer effects. |
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T40838 |
20-O-Demethyl-AP3
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20-O-Demethyl-AP3 |
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20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules. |
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T30794 |
Centmitor-1
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Centmitor 1 |
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Centmitor-1 is a novel mitotic inducer that modulates the positive end of microtubules and reduces microtubule dynamics. |
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T68570 |
TPI-287
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TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cyc... |
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T68686 |
DAP-81
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DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50... |
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T37733 |
AMP-PNP tetralithium
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|
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Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.
Brady (1985) A novel brain ATPase with properties expect... |
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T36358 |
Diminutol
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|
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Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization ... |
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T18278 |
Mal-PEG2-VCP-Eribulin
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Others
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Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a no... |
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T62966 |
IQTub4P
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IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM). |
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T80921 |
Tubulin/JAK2-IN-1
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Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1]. |
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T69003 |
E7974
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E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inh... |
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T69480 |
Sagopilone
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Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymeri... |
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T71577 |
KOS-1584
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KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which m... |
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T68232 |
Epofolate
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Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated th... |
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T28179 |
NMK-TD-100
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NMK-TD 100,NMK-TD100 |
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NMK-TD-100 is a microtubule modulating agent with anti-proliferative activity by disrupting microtubule functions through tubulin binding. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubul... |
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T70006 |
DHA-paclitaxel
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DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells t... |
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T68860 |
Iso-Fludelone
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Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules agai... |
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T37066 |
9-(2,2-Dicyanovinyl)julolidine
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9-(2,2-Dicyanovinyl)julolidine (DCVJ) is a fluorogenic dye that is considered a fluorescent molecular rotor because its properties depend on the rotational relaxation of the molecule, which can be influenced by the visco... |
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T70235 |
Cemadotin hydrochloride
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Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15,... |
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T83814 |
8-Bromoguanosine-5'-O-triphosphate sodium
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8-bromo GTP |
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8-Bromoguanosine-5'-O-triphosphate, a derivative of guanosine 5'-triphosphate (GTP) - the energy substrate for protein synthesis and gluconeogenesis, acts as an inhibitor of the E. coli GTPase FtsZ with an inhibition con... |
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T36856 |
UA 62784
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Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. O... |
