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T5345 |
V-9302
|
|
Others
|
|
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). |
|
T10717 |
Inobrodib
|
CBP-IN-1 |
Epigenetic Reader Domain
|
|
Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain. |
|
T9072 |
Tuxobertinib
|
BDTX-189 |
EGFR
,
HER
,
BTK
,
RIP kinase
|
|
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ... |
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T11279 |
FGFR1/DDR2 inhibitor 1
|
|
Discoidin Domain Receptor (DDR)
,
FGFR
,
Others
|
|
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. |
|
T12134 |
MYCMI-6
|
NSC354961 |
Apoptosis
,
c-Myc
|
|
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions，reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve... |
|
T1290 |
Oxiconazole nitrate
|
Ro 13-8996 |
Others
,
Antibiotic
,
Antifection
,
Antifungal
|
|
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole... |
|
T10313 |
AMXT-1501 tetrahydrochloride
|
|
Others
|
|
AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport. It blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. |
|
T8973 |
HS-1793
|
|
Others
|
|
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model |
|
T27866 |
LXY6090
|
LXY 6090,LXY-6090 |
|
|
LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF-1α in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression i... |
|
T71494 |
ISC-4
|
|
|
|
ISC-4 is an Akt inhibitor, which activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. |
|
T69479 |
CGC 11093
|
|
|
|
CGC 11093 is a polyamine analog; inhibits growth of human prostate tumor xenografts in nude mice. It may prove useful in promoting regression of choroidal neovascularization. |
|
T25367 |
EM-800
|
EM800,EM 800 |
|
|
EM-800 is a high affinity ligand for estrogen receptor-α (ERα), the prodrug of EM-652. EM-800 independently inhibited the growth of E1-stimulated ZR-75-1 xenograft tumors in nude mice. |
|
T24188 |
J-104871
|
UNII-6137X5QNJF,J 104871 |
|
|
J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-trans... |
|
T61532 |
Tubulin polymerization-IN-6
|
|
|
|
Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Addition... |
|
T72620 |
C-Myc inhibitor 9
|
|
|
|
c-Myc Inhibitor 9 (Compound 332) is an effective c-Myc inhibitor, exhibiting a logEC50 of ≥6, and demonstrating significant tumor growth inhibition in nude mouse models. This compound is utilized in cancer research. |
|
T82802 |
BX-2819
|
|
HSP
|
|
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 tumor cells in nude mice[1]. |
|
T68875 |
Xylocydine
|
|
|
|
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as... |
|
T74691 |
Aprinocarsen sodium
|
|
|
|
Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor targeting protein kinase C-alpha (PKC-α). It is a 20-mer oligonucleotide that modulates cell differentiation and proliferation. Demonstrat... |
|
T75363 |
Fluorescein Di-β-D-Glucuronide
|
|
|
|
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, enables non-invasive imaging of intestinal bacterial β-glucuronidase activity in nude mice. This compound's utilization for both in vitro and in vivo imaging offers va... |
|
T73693 |
Peginterferon beta-1a
|
|
|
|
Peginterferon beta-1a (Peginterferon β-1a), the inaugural pegylated interferon beta-1a derivative, promotes apoptosis in cancer cells and exhibits anti-tumor properties in nude mice models. It is utilized in the study of... |
|
T68346 |
KRN383
|
|
|
|
KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prol... |
|
T61582 |
Anticancer agent 57
|
|
|
|
Anticancer agent 57 (compound 14) demonstrates potent inhibition of MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC 50 values ranging from 6.43 to 8.00 μM. Additionally, this agent induces cell cycle arrest and pro... |
|
T36191 |
CAY10681
|
|
|
|
Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling. It potently binds MDM2 (Ki = 250 nM)... |
|
T79261 |
P-gp inhibitor 15
|
|
|
|
P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123 efflux. Additionally, this compound enhances the inhibitory ef... |
|
T63864 |
Antiproliferative agent-4
|
|
|
|
Antiproliferative agent-4 showed good anti-proliferative effects on some cancer cells. antiproliferative agent-4 inhibited tumour growth in nude mice and showed low toxicity. antiproliferative agent-4 reduced the mitocho... |
|
TP1974 |
Obtustatin
|
|
|
|
Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chor... |
|
T74783 |
HDAC-IN-53
|
|
HDAC
|
|
HDAC-IN-53 is an orally active, selective inhibitor of HDAC1-3, demonstrating IC50 values of 47 nM, 125 nM, and 450 nM, respectively. It exhibits no inhibitory effects on class II HDACs (HDAC4, 5, 6, 7, 9; IC50 >10 μM). ... |
|
T29172 |
YD277
|
YD 277,YD-277 |
|
|
YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC c... |
|
T37844 |
Kigamicin C
|
|
|
|
Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including me... |
|
T64027 |
ALK-IN-23
|
|
|
|
ALK-IN-23 is a potent inhibitor of ALK, acting on ALKWT (IC50: 1.6 nM), ALKL1196M (IC50: 0.71 nM) and ALKG1202R (IC50: 1.3 nM). -IN-23 has inhibitory effects on cancer cell migration and colony formation in vitro. In the... |
|
T78788 |
EGFR-IN-82
|
|
EGFR
|
|
EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/T790M/C797S. It lacks significant inhibitory effects on EGFR ... |
|
T68249 |
IRC-083927 HCl
|
|
|
|
IRC-083927 HCl is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of... |
|
T73121 |
FGFR4-IN-8
|
|
FGFR
|
|
FGFR4-IN-8 (Compound 7v) is an ATP-competitive inhibitor that covalently and highly selectively targets both the wild-type and gatekeeper mutant forms of FGFR4. It shows excellent inhibitory potency with IC50s of 0.5 nM ... |
|
T71279 |
BPR1K653
|
|
|
|
BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was poten... |
|
T36084 |
PKI-179
|
|
|
|
PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-α, 24 nM for PI3K-β, 74 nM for PI3K-γ, 77 nM for PI3K-δ, and 0.42 nM for mTOR. Additi... |
|
T65994 |
(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
|
|
|
|
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ... |
|
T37585 |
Ensartinib
|
|
|
|
Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or ... |
