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T27837 |
Linzagolix
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GNRH Receptor
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Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which is under development by Kissei Pharmaceutical and ObsEva for the treatment of uterine fibroids,... |
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T6713 |
Ulipristal
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Estrogen/progestogen Receptor
,
Progesterone Receptor
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Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. |
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T2527 |
Ulipristal acetate
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Ulipristal,CDB-2914 |
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
Autophagy
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Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb... |
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T3630 |
Relugolix
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RVT-601,TAK-385 |
GNRH Receptor
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Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi... |
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T22285 |
Carboprost
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15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α |
Prostaglandin Receptor
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Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone. |
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T35054 |
Vilaprisan
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BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670 |
Progesterone Receptor
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Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids. |
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T1433 |
Ritodrine hydrochloride
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DU21220,Ritodrine HCl,NSC 291565 |
Adrenergic Receptor
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Ritodrine hydrochloride (NSC 291565) binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Ritodrine hydrochloride (NS... |
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T5148 |
Atosiban acetate
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RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 |
Oxytocin Receptor
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Vasopressin Receptor
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Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... |
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T23516 |
VU590
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Potassium Channel
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VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling. |
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T28855 |
SSR126768A
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SSR-126768A,SSR 126768A |
Oxytocin Receptor
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SSR126768A is a novel and selective, orally active and potent oxytocin (OT) receptor antagonist with inhibitory effects on uterine contractions for the prevention of preterm labor. |
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T78646 |
Estrogen receptor antagonist 8
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Estrogen/progestogen Receptor
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Estrogen receptor antagonist 8 acts as an estrogen receptor (ER) antagonist with anti-uterine activity and potential anti-tumorigenic activity and can be used to study ovarian dysfunction. |
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T0324 |
Isoxsuprine hydrochloride
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Duvadilan,Isolait |
Adrenergic Receptor
,
iGluR
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Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. |
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T25742 |
Linzagolix choline
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GNRH Receptor
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Linzagolix choline is an orally available non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It can be used to study pain associated with uterine fibroids and endometriosis. |
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T11915 |
LY88074
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Estrogen/progestogen Receptor
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LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation. |
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T13572 |
Cancer-Targeting Compound 1
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Others
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Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among othe... |
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T60039 |
KSQ-4279
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USP1-IN-1 |
PARP
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DUB
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KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ... |
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T1514 |
Norethindrone
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Norethisterone |
Estrogen/progestogen Receptor
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Progesterone Receptor
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Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties... |
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T10379 |
Arzoxifene hydrochloride
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SERM 3,LY 353381 HCl |
Others
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Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. |
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T32684 |
Leuprolide (1-3)
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Leuprorelin |
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Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty. |
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T34639 |
Sigetin
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Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development. |
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T4996 |
Atosiban
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RWJ22164,RW22164 |
Oxytocin Receptor
,
Vasopressin Receptor
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Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated rel... |
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T69303 |
Isoxsuprine Free Base
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Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplyi... |
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T26669 |
Asoprisnil ecamate
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J956,J-956,J 956 |
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Asoprisnil ecamate is a selective progesterone receptor modulator. Asoprisnil inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cell... |
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T21387 |
Nafoxidine HCl（1845-11-0 Free base）
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PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl |
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Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium... |
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T37435 |
PACAP-related Peptide (rat) (trifluoroacetate salt)
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PACAP
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PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adeny... |
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T36154 |
15(S)-15-methyl Prostaglandin E2
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15(S)-15-methyl Prostaglandin E2 |
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15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is te... |
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T76996 |
Solitomab
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Solitomab (AMG 110), a bispecific antibody targeting CD3 and EpCAM, is utilized in researching primary uterine and ovarian carcinosarcoma cancer [1] [2]. |
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T60575 |
Ritodrine
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Ritodrine (DU21220) is a β-adrenergic agonist as well as an effective uterine relaxant that can be used in arrest premature labor research[1] [2]. |
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T0171 |
Norethynodrel
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Lynestrol |
Estrogen/progestogen Receptor
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Norethynodrel (Lynestrol) is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contracepti... |
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T21308 |
Histrelin
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Supprelin LA,Histrelin Acetate |
Others
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Histrelin (Supprelin LA) acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of th... |
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T36155 |
15(S)-15-methyl Prostaglandin F2α isopropyl ester
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15(S)-15-methyl Prostaglandin F2α isopropyl ester |
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15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2α isopropyl es... |
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T36771 |
11-deoxy Prostaglandin F1α
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11-deoxy Prostaglandin F1α |
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11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that ... |
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T26665 |
AS604872
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AS-604872,AS 604872 |
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AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic l... |
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T80955 |
Trastuzumab duocarmazine
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(vic)-Trastuzumab duocarmazine |
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Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is an ADC targeting HER2 that undergoes cleavage by histone B within tumor cells, thereby achieving selective targeting of these cells. It exhibits antitumor acti... |
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T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
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C16 Globotriaosylceramide (d18:1/16:0) |
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C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raj... |
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T76211 |
[Asp5]-Oxytocin acetate
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[Asp5]-Oxytocin acetate is a neurohypophyseal hormone analogue positioned at the 5-position, noted for its significant biological activity. It stimulates uterine contractions in vitro, an effect that is amplified by the ... |
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T71149 |
Triptorelin pamoate
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Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituita... |
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T35669 |
Neuromedin C (trifluoroacetate salt)
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Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide... |
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T72990 |
BAY 1214784
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BAY 1214784, a potent, selective, and orally active spiroindoline derivative compound, serves as an antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). It notably reduces plasma luteinizing hormone... |
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T69492 |
Ozarelix
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Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antag... |
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T76565 |
PDC31
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PDC31 (THG113.31; ILGHXDYK) is a D-amino acid-based oligopeptide that acts as an allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor, used primarily as a smooth muscle contractile agent. It effectiv... |
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T68525 |
Nafarelin acetate hydrate
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Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estroge... |
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T19811 |
Nomegestrol
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Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives. |
