|
T3560 |
Desmethylanethol trithione
|
ADT-OH |
VEGFR
,
Akt
|
|
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly... |
|
T9196 |
IACS-13909
|
BBP-398 |
Phosphatase
|
|
IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway. |
|
T60060 |
ACSS2-IN-2
|
MTB-9655 |
Fatty Acid Synthase
|
|
ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis... |
|
T5337 |
IACS-010759
|
IACS-10759,IACS 10759,IACS10759 |
Apoptosis
,
Others
,
Mitochondrial Metabolism
|
|
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain. |
|
T27568 |
IACS-010759 hydrochloride
|
IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759 |
|
|
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NA... |
|
T69759 |
IACS-9439
|
|
c-Fms
|
|
IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM. It is applicable in the research of advanced solid tumors [1]. |
|
T11595 |
IACS-8779
|
|
Others
|
|
|
|
T73939 |
IACS-8803 diammonium
|
|
|
|
IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1]. |
|
T73938 |
IACS-8803 disodium
|
|
|
|
IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1]. |
|
T11627 |
IACS-8968 R-enantiomer
|
IDO/TDO Inhibitor (R-enantiomer) |
IDO
|
|
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
|
T63397 |
ACSS2-IN-1
|
|
|
|
ACSS2-IN-1 is a potent inhibitor of ACSS2, capable of inhibiting ACSS2 activity with IC50 values ranging from 0.01 nM to <1 nM, and can be used in cancer research. |
|
T11596 |
IACS-8803
|
|
Others
|
|
IACS-8803 is a potent cyclic dinucleotide STING agonist that exhibits strong systemic antitumor efficacy. |
|
T27289 |
Etacstil
|
GW 5638,GW-5638,GW5638,DPC974,DPC 974,DPC-974 |
|
|
GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. G... |
|
T11544 |
HDACs/mTOR Inhibitor 1
|
|
HDAC
|
|
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα). |
|
T11628 |
IACS-8968 S-enantiomer
|
IDO/TDO Inhibitor (S-enantiomer) |
IDO
|
|
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
|
T70091 |
IACS-4759
|
|
|
|
IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes. |
|
T78566 |
GlcNAcstatin
|
|
|
|
GlcNAcstatin, a selective glucoimidazole-based inhibitor of bacterial O-GlcNAcase, exhibits a K_i value of 4.6 pM and demonstrates a specificity that is 100,000-fold greater than that for HexA/B [1]. |
|
T11597 |
IACS-9571
|
ASIS-P040 |
Epigenetic Reader Domain
|
|
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). |
|
T72274 |
IACS-9571 hydrochloride
|
ASIS-P040 hydrochloride |
|
|
IACS-9571 (ASIS-P040) hydrochloride is a potent, selective inhibitor of TRIM24 and BRPF1, demonstrating an IC50 of 8 nM for TRIM24, and dissociation constants (Kd) of 31 nM and 14 nM for TRIM24 and BRPF1, respectively. |
|
T39999 |
IACS-15414
|
|
|
|
IACS-15414 is a potent SHP2 inhibitor that is effective when administered orally, demonstrating an IC50 value of 122 nM. |
|
T62298 |
PHD2/HDACs-IN-1
|
|
|
|
PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 μM), HDAC1 (IC50: 19.75 μM), HDAC2 (IC50: 26.60 μM), HDAC16 (IC50: 15.98 μM). HDACs-IN-1 is a low toxicity nephroprotective agent that... |
|
T11626 |
IACS-8968
|
IDO/TDO Inhibitor |
IDO
|
|
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
|
T72516 |
IACS-8779 disodium
|
|
|
|
IACS-8779 disodium, a highly potent STING (stimulator of interferon genes) agonist, demonstrates robust activation of the STING pathway in vitro, along with superior systemic antitumor efficacy. This compound shows a sig... |
|
T79303 |
IACS-52825
|
|
|
|
IACS-52825 is a potent, selective DLK inhibitor, exhibiting a dissociation constant (Kd) of 1.3 nM, and is valuable for researching chemotherapy-induced peripheral neuropathy (CIPN) [1]. |
|
T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
|
IACS-9571 Hydrochloride,ASIS-P040 Hydrochloride |
Epigenetic Reader Domain
|
|
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). |
|
T22551 |
ACSF
|
|
Others
|
|
ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often u... |
|
T68088 |
Iodofiltic acid
|
|
|
|
Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia. |
|
T21059 |
Ticagrelor metabolite M5
|
Ticagrelor metabolite M5,,T437700,AR-C133913XX |
P2Y Receptor
|
|
Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has faster and more consistent inhibition on ADP-receptors. Ti... |
|
T76124 |
Acyl coenzyme A synthetase
|
|
|
|
Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, plays a pivotal role in biochemical research. This enzyme catalyzes the activation of fatty acids via coenzyme A through a two-step thioesteri... |
|
T35674 |
StRIP16
|
|
|
|
Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.
Cromm et al (2016) Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase. ACS ... |
|
T36016 |
PF 06260933 dihydrochloride
|
|
|
|
MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
Ammirati et al (2015) Discovery of an in vivo tool t... |
|
T36782 |
TAK1-IN-2
|
TAK1-IN-2 |
|
|
TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1].
TAK1-IN-2 (compound 54) (10 μM) has no effect on cell viability in TNF-α stimulated HCT-15 cells[1].
[1]. Veerman JJN, et, al. Discovery of 2,... |
|
T36910 |
PF 04449913 maleate
|
|
|
|
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
Munchhof et al (2011) Discov... |
|
T36634 |
ZQ 16
|
|
|
|
Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK... |
|
T36946 |
PW0464
|
PW0464 |
|
|
PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1].
PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R... |
|
T35817 |
Photoswitchable PAD Inhibitor (technical grade)
|
|
|
|
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without ph... |
|
T36504 |
STY-BODIPY
|
STY-BODIPY,Styrene-BODIPY |
|
|
STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the l... |
|
T35488 |
(S)-PI3Kα-IN-4
|
(S)-PI3Kα-IN-4 |
|
|
(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the... |
|
T35638 |
SR 1903
|
|
|
|
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al... |
|
T38106 |
JC-171
|
|
|
|
JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1]. |
|
T35527 |
PI3Kα-IN-4
|
PI3Kα-IN-4 |
|
|
PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1]. |
