|
T8478 |
SC-43
|
|
Apoptosis
,
Phosphatase
,
STAT
|
|
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects. |
|
T6576 |
Malotilate
|
Malotilatum,NKK 105,Kantec |
Lipoxygenase
|
|
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis. |
|
T6867 |
Belumosudil
|
KD025,Rezurock,ROCK inhibitor,SLx-2119 |
ROCK
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
|
T12584 |
PXS-5120A
|
|
Others
,
Monoamine Oxidase
|
|
PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity. |
|
T3350 |
Selonsertib
|
GS-4997 |
Apoptosis
,
ASK
,
MAPK
|
|
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
|
T7298 |
FT011
|
|
Others
|
|
FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy. |
|
T12883 |
Fezagepras
|
PBI-4050,Setogepram |
GPR
|
|
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. |
|
T12375 |
Fezagepras sodium
|
Setogepram sodium salt,PBI-4050 sodium salt |
GPR
|
|
Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-proliferative actions. |
|
T10087 |
24-Norursodeoxycholic acid
|
nor-UDCA |
Others
|
|
24-Norursodeoxycholic acid (nor-UDCA) is a side chain-shortened C23 homolog of UDCA.It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties.It is a Ursodeoxycholic Acid derivative. It is sup... |
|
TP1223L |
Apamin acetate
|
Apamine acetate,Apamin acetate(24345-16-2 Free base) |
Potassium Channel
|
|
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following lacera... |
|
T38164 |
MnTBAP chloride
|
Mn(III)TBAP |
|
|
MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ... |
|
T15664 |
KIRA-7
|
|
Others
|
|
KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity. |
|
T16101 |
ML-290
|
|
RXFP receptor
|
|
ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM. |
|
T39555 |
Belumosudil mesylate
|
SLx-2119mesylate,KD025 mesylate |
|
|
Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties. |
|
TP1223 |
Apamin
|
Apamine |
|
|
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic acti... |
|
T33595 |
Naproxcinod
|
AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582 |
|
|
Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in... |
|
T70622 |
Selonsertib HCl
|
|
|
|
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and b... |
|
T70421 |
VCP746
|
|
|
|
VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moie... |
|
T74544 |
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
|
|
|
|
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-target PROTAC capable of directing ubiquitination and degradation of Smad3 while also elevating HIF-α protein levels. This compound exhibits both multipath anti... |
|
T75746 |
Apamin TFA
|
|
|
|
Apamin TFA, also known as Apamine TFA, is an 18-amino acid peptide neurotoxin derived from apitoxin (bee venom). It functions as a specifically selective blocker of Ca2+-activated K+ (SK) channels and demonstrates anti-i... |
|
T62301 |
J-1063
|
|
|
|
J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has poten... |
|
T76331 |
Cortistatin 29
|
|
|
|
Cortistatin 29, a neuropeptide, alleviates neuropathic pain and exhibits anti-fibrotic effects. It binds with high affinity to all somatostatin (SS) receptor subtypes, displaying IC 50 values of 2.8 nM for SSTR1, 7.1 nM ... |
|
T37495 |
Angiotensin (1-7) (acetate)
|
|
|
|
Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through its anti-inflammatory and anti-fibrotic activities in cardiac cells. It e... |
|
T79731 |
MLKL-IN-6
|
|
Necroptosis
|
|
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit... |
