CDK9 | TargetMol

カタログ番号	製品名	別名	ターゲット
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T10742	CDK9-IN-10		CDK
	CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.		CDK
T9632	CDK9-IN-30		HIV Protease
	CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.		HIV Protease
T118066	CDK9 inhibitor HH1	8019-9719	CDK
	CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.		CDK
T10746	CDK9-IN-8		CDK
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).		CDK
T14918	CDK9-IN-2		Others , CDK
			Others , CDK
T39354	CDK9-IN-12	CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T36744	CDK9 Antagonist-1	CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form...
T60619	CDK9-IN-15		CDK
	CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CD...		CDK
T39997	PROTAC CDK9 ligand-1	PROTAC CDK9 ligand-1
	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T39996	PROTAC CDK9 degrader-4	PROTAC CDK9 degrader-4
	PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9...
T10743	CDK9-IN-11		CDK
	CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].		CDK
T5438	PROTAC CDK9 Degrader-1		CDK
	PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.		CDK
T10741	CDK9-IN-1		CDK
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).		CDK
T10747	CDK9-IN-9		CDK
	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).		CDK
T70400	CDK9/CycT1-IN-93
	CDK9/CycT1-IN-93 is a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.
T17728	PROTAC CDK9 degrader-2		Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to...		Others
T79037	CDK9-IN-23		CDK
	CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].		CDK
T63054	CDK9-IN-18
	CDK9-IN-18 is a potent inhibitor of CDK9 that blocks the phosphorylation of the kinase CDK9. CDK9-IN-18 exhibits good anticancer activity and low cellular activity and is able to induce apoptosis.
T79704	CDK9-IN-28		CDK
	PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis. Exhibiting substantial anti-proliferative activity in solid tumors [1], this compound is instr...		CDK
T82757	CDK9-IN-29		CDK
	CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM. It effectively hinders cell proliferation and induces apoptosis [1].		CDK
T79630	CDK9-IN-25		Virus Protease
	CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM. It also exhibits affinity for the main protease of COVID-19 and demonstrates antiviral activity against huma...		Virus Protease
T63490	CDK9-IN-19
	CDK9-IN-19 is a selective and potent CDK9 inhibitor (IC50: 2.0 nM). CDK9-IN-19 exhibits good anti-proliferative activity in cancer cells, moderate pharmacokinetic properties and low hERG inhibition. CDK9-IN-19 significan...
T79631	CDK9-IN-26		CDK
	CDK9-IN-26, also known as compound 1, is a potent inhibitor of Cyclin-Dependent Kinase 9 (CDK9) with an IC50 value of 0.18 μM.[1]		CDK
T62919	CDK9-IN-13
	CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.
T79367	CDK9-IN-27		CDK
	CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest. It exhibits cytotoxicity against HepG2, HCT-116, and MCF-7 cell lines, with IC50 values ranging from 1...		CDK
T79354	CDK9-IN-24		CDK
	CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation. It impedes cell growth and triggers apoptosis via the downregulation of Mcl-1 and...		CDK
T62203	CDK9-IN-14
	CDK9-IN-14 is a potent, high and low selective CDK9 inhibitor (IC50: 6.92 nM). CDK9-IN-14 is a strong inhibitor of MV-4-11 cells and in vivo tumour models with low toxicity and few side effects.
T74851	PROTAC CDK9 degrader-5		PROTACs
	PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway. It efficiently degrades the CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1...		PROTACs
T78928	PROTAC CDK9 degrader-8		PROTACs
	PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].		PROTACs
T74852	PROTAC CDK9 degrader-6		CDK
	PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 with DC50 values of 0.10 μM and 0.14 μM for the CDK9 42 and...		CDK
T74853	PROTAC CDK9 degrader-7
	PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (CDK9) through the proteasome pathway [1].
T79904	PROTAC CDK9/CycT1 Degrader-2		CDK
	PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].		CDK
T62746	EGFR/HER2/CDK9-IN-1
	EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent EGFR/HER2/CDK9 inhibitor with IC50 values of 90.17, 131.39 and 67.04 nM. EGFR/HER2/CDK9-IN-1 exhibits significant anti-tumour effects.
T63357	EGFR/HER2/CDK9-IN-2
	EGFR/HER2/CDK9-IN-2 are potent inhibitors of EGFR/HER2/CDK9, and they exhibited significant antitumor effects with IC50s of 145.35, 129.07 and 117.13 nM, respectively.
T63851	CDK9/10/GSK3β-IN-1
	CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 μM and 1.725 μM, respectively. CDK...
T74707	PROTAC FLT3/CDK9 degrader-1
	PROTAC FLT3/CDK9 degrader-1, a potent dual degrader of FLT3 and CDK9, effectively induces apoptosis and targets protein degradation of FLT3 and CDK9. This compound holds research potential for FLT3-ITD mutated AML [1].
T63161	EGFR/HER2/CDK9-IN-3
	EGFR/HER2/CDK9-IN-3 (Compound 10) is a potent inhibitor of EGFR (IC50:191.08 nM), HER2 (IC50:132.65 nM), and CDK9 (IC50:113.98 nM). EGFR/HER2/CDK9-IN-3 showed significant anti-tumor effects.
T82758	CDK9-Cyclin T1 PPI-IN-1		CDK
	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt...		CDK
T16363	NVP-2		Apoptosis , CDK
	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...		Apoptosis , CDK
T10096L	Voruciclib		CDK
	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...		CDK
T9615	CK7		CDK
	CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.		CDK
T70399	TTC-352
	TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring...
T9446	KB-0742 dihydrochloride		CDK
	KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.		CDK
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
TQ0078	CDK-IN-2	CDK inhibitor II	CDK
	CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).		CDK
T8796	CAN508		CDK
	CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...		CDK
T6563	LDC000067	LDC067	Apoptosis , CDK
	LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.		Apoptosis , CDK
T10436	AZD4573		CDK
			CDK
T6206	PHA-767491	CAY10572,PHA767491,PHA 767491	cholecystokinin , GSK-3 , CDK
	PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.		cholecystokinin , GSK-3 , CDK

Compounds

CDK9-IN-7

T10745

Target: Others, CDK

CDK9-IN-12

T39354

Synonym: CDK9-IN-12

Target:

CDK9 Antagonist-1

T36744

Synonym: CDK9 Antagonist-1

PROTAC CDK9 ligand-1

T39997

Synonym: PROTAC CDK9 ligand-1

Target:

PROTAC CDK9 degrader-4

T39996

Synonym: PROTAC CDK9 degrader-4

PROTAC CDK9 Degrader-1

PROTAC CDK9 degrader-2

Target: Virus Protease

PROTAC CDK9 degrader-5

T74851

Synonym:

Target: PROTACs

PROTAC CDK9 degrader-8

T78928

Synonym:

Target: PROTACs

PROTAC CDK9 degrader-6

T74852

Synonym:

Target: CDK

PROTAC CDK9 degrader-7

T74853

Synonym:

Target:

PROTAC CDK9/CycT1 Degrader-2

T79904

Synonym:

Target: CDK

EGFR/HER2/CDK9-IN-1

T62746

Synonym:

Target:

EGFR/HER2/CDK9-IN-2

PROTAC FLT3/CDK9 degrader-1

T74707

Synonym:

Target:

EGFR/HER2/CDK9-IN-3

T63161

Synonym:

Target:

CDK9-Cyclin T1 PPI-IN-1

Target: Apoptosis, CDK

KB-0742 dihydrochloride

Target: Others, DNA/RNA Synthesis, CDK, HSV

CDK-IN-2

TQ0078

Synonym: CDK inhibitor II

Target: Apoptosis, CDK

Synonym: CAY10572,PHA767491,PHA 767491

Target: cholecystokinin, GSK-3, CDK

カタログ番号	製品名	別名	ターゲット
T17143	Toyocamycin	Vengicide	Apoptosis , Others , IRE1 , Antibiotic , Antifungal
	Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.		Apoptosis , Others , IRE1 , Antibiotic , Antifungal
TN1068	Tricin		Others , CDK
	Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.		Others , CDK

カタログ番号	製品名	Species	Expression System
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...

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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

Compounds

天然物製品

Recombinant Proteins