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T63337 |
CYP2C19-IN-1
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|
|
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CYP2C19-IN-1 is a potent, non-genotoxic, non-hepatotoxic inhibitor of CYP2C19. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) (Ki: 6.16 μM) and can be used to study Zika virus (ZIKV) infection. |
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T63495 |
CYP2C1/CYP2C19-IN-2
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|
|
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CYP2C1/CYP2C19-IN-2 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection. |
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T63496 |
CYP2C9/CYP2C19-IN-1
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|
|
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CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection. |
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T21529 |
(S)-Mephenytoin
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|
Others
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(S)-Mephenytoin ((+)-Mephenytoin) anticonvulsant effect. It is a substrate of the cytochrome P450 (CYP) isoform CYP2C19 and can be used to analyze cytochrome P450 metabolism. |
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T3610 |
Ranitidine
|
HSDB 3925,Ranitidin |
P450
,
Antibacterial
,
Histamine Receptor
|
|
Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. |
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T21425 |
Mephenytoin
|
Mesantoin,Methoin,Insulton,Phenantoin,Methylphenetoin |
P450
|
|
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6. |
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T0865 |
Ranitidine Hydrochloride
|
AH19065 |
P450
,
Antibacterial
,
Histamine Receptor
|
|
Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enteroc... |
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T4190 |
Ticlopidine
|
PCR 5332,Ticlid |
ATPase
,
Adiponectin receptor
|
|
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. |
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T21029 |
Norfluoxetine Hydrochloride
|
Norfluoxetine HCl |
Others
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Norfluoxetine Hydrochloride (Norfluoxetine HCl) is an active metabolite of fluoxetine. Fluoxetine is an antidepressant drug. |
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T0182L |
Clopidogrel hydrogen sulfate
|
(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel |
P450
,
P2Y Receptor
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Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. |
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T67926 |
(S)-(+)-N-3-Benzylnirvanol
|
ZSN-76403 |
P450
,
HIV Protease
|
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(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection. |
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T4498 |
Stiripentol
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BCX2600,Diacomit |
P450
|
|
Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM... |
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T37332 |
(±)-N-3-Benzylnirvanol
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P450
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(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll. (+) -n-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll are selective inhibitors of cytochrome P450 that inhibit CYP2C19, a... |
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T22391 |
Omeprazole Sodium
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|
P450
,
Proton pump
,
Antibacterial
,
Autophagy
|
|
Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive... |
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T9335 |
1,1'-Methylenedi-2-naphthol
|
Squoxin |
Others
|
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1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human). |
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T10138 |
4-Desmethoxy Omeprazole
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|
Drug Metabolite
|
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4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 activity (Ki: 2 to 6 μM). |
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T20570 |
Labetalol
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Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne |
Adrenergic Receptor
|
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Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... |
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T4567 |
Sulfaphenazole
|
Plisulfan,Raziosulfa,Depocid,Depotsulfonamide |
P450
,
Antibacterial
|
|
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1... |
|
T0757 |
Omeprazole
|
Losec,Prilosec,H 16868,Antra |
Proton pump
,
Phospholipase
,
Antibacterial
,
Autophagy
|
|
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). |
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T1149 |
Fenofibrate
|
Procetofen,Lipanthyl,Lipantil |
P450
,
PPAR
,
Autophagy
|
|
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. |
|
T6249 |
Avagacestat
|
BMS-708163 |
Gamma-secretase
|
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Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
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T23586 |
5-Hydroxylansoprazole sulfone
|
AG1909,AG 1909,AG-1909 |
|
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5-hydroxylansoprazole is an in vitro metabolism-dependent CYP2C19 inhibitor. |
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T37247 |
Pantoprazole Sulfide
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|
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Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4 to form pantoprazole sulfide. |
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T37796 |
Voriconazole N-oxide
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|
|
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Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19. |
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T36530 |
Pantoprazole sulfone
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|
|
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Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A4 to form pantoprazole sulfone. |
|
T14051 |
5-Hydroxylansoprazole
|
AG1908 |
Proton pump
|
|
5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, result... |
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T35431 |
(±)-Clopidogrel (hydrochloride)
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|
|
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ... |
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T36112 |
Clopidogrel Carboxylic Acid (hydrochloride)
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|
|
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ... |
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T2753 |
Avasimibe
|
PD-148515,CI-1011 |
P450
,
Acyltransferase
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|
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
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T36840 |
(R)-Omeprazole (sodium salt)
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|
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(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxid... |
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T37659 |
5-hydroxy Omeprazole
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|
|
|
5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxy... |
|
T78590 |
Dibenzylfluorescein
|
DBF |
|
|
Dibenzylfluorescein (DBF), a fluorogenic probe (Fluorescent dye), serves as a substrate for various cytochrome P450 (CYP) isoforms, such as CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). It is commonly utilized ... |
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T78925 |
HIV-1 inhibitor-58
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|
|
|
HIV-1 Inhibitor-58 (Compound 10c) is a non-nucleoside reverse transcriptase inhibitor with broad-spectrum antiviral properties, effective against both wild-type strain IIIB and NNRTI-resistant strains like K103N and E138... |
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T38131 |
(E)-10-Hydroxynortriptyline
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|
|
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1... |
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T35718 |
N-desmethyl Rosuvastatin (sodium salt hydrate)
|
|
|
|
N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) is... |
|
T79568 |
NPD-2975
|
|
Parasite
|
|
NPD-2975 (compound 30) is an orally active antitrypanosomal agent effective against Human African Trypanosomiasis (HAT), demonstrating acceptable metabolic stability and low toxicity potential in human MRC-5 lung fibrobl... |
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T71302 |
Norfluoxetine-d5 HCl
|
|
|
|
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine b... |
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T62452 |
HIV-1 inhibitor-40
|
|
|
|
HIV-1 inhibitor-40 (Compound 4ab) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) (EC50: 1.9 nM) with no significant acute toxicity in vivo. Orexin receptor antagonist is a highly sensitive inhibitor o... |
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T7788 |
2-Phenyl-2-(1-piperidinyl)propane
|
|
Others
|
|
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine |
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T35829 |
CC-90005
|
|
|
|
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by I... |
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T10535 |
BI 653048
|
|
P450
|
|
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor. |
|
T10535L |
BI 653048 phosphate
|
|
P450
|
|
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM). |
