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Search Results for " FLT3-IN-3 "

ターゲット

阻害剤

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T11298	FLT3-IN-3		FLT
	FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.		FLT
T11299	FLT3-IN-4	FLT3 inhibitor 9u	FLT
	FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.		FLT
T1938	FLT3-IN-2		FLT
	FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).		FLT
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T11300	FLT3-IN-6		Others
	FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.		Others
T24067	Flt3 Inhibitor IV	Flt3 Inhibitor-IV,Flt3-IN-IV
	Flt3 Inhibitor IV is a potent ATP-competitive Flt3 inhibitor.
T62824	FLT3/ITD-IN-3
	FLT3/ITD-IN-3 (Compound 19) is a potent inhibitor of FLT3-ITD, acting on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 0.9 nM). FLT3/ITD-IN-3 showed potent inhibition of FLT3 phosphorylation and was e...
T63127	PDGFRα/FLT3-ITD-IN-3
	PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk...
T9856	FLT3-IN-10	2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl-	FLT
	FLT3-IN-10 (2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl-) (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 shows the potential for the treatment of FLT3-mutated acute myeloid leukemia (...		FLT
T4409	Gilteritinib	ASP2215	FLT , TAM Receptor , c-Kit
	Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...		FLT , TAM Receptor , c-Kit
T2272	BPR1J-097	BPR1J097	FLT
	BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).		FLT
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T2500	Cediranib	AZD2171,NSC-732208	VEGFR , FLT , PDGFR , c-Kit , Autophagy
	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...		VEGFR , FLT , PDGFR , c-Kit , Autophagy
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T2638	Gandotinib	LY2784544	VEGFR , FGFR , FLT , JAK
	LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.		VEGFR , FGFR , FLT , JAK
T11707	JAK2/FLT3-IN-1		JNK
	JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F...		JNK
T82392	FLT3-IN-23
	FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effects against BaF3 cells harboring diverse FLT3-TKD and FLT3-ITD-...
T79391	FLT3-IN-21
	FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-...
T12610L	3-Hydroxy Midostaurin	CGP52421	FLT
	3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it ...		FLT
T71400	Quizartinib HCl
	Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III recept...
T61358	AKN-028 acetate
	AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC 50 value of 6 nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN...
T37085	Luxeptinib
	Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induce...
T78871	PLM-101
	PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, con...
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 ...

Compounds

Synonym: FLT3 inhibitor 9u

Synonym: FLT3-IN-1,FLT3-IN-1

Synonym: Flt3 Inhibitor-IV,Flt3-IN-IV

PDGFRα/FLT3-ITD-IN-3

Synonym: 2-Oxazolamine, 5-(4-fluorophenyl)-N-phenyl-

Target: FLT, TAM Receptor, c-Kit

Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251

Target: Others, PKC

Cediranib

T2500

Synonym: AZD2171,NSC-732208

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Target: VEGFR, FGFR, FLT, JAK

3-Hydroxy Midostaurin

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-00125	FLT3 Ligand Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg...
TMPK-00929	FLT3 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg...
TMPY-00892	Neuropilin-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3.
TMPY-01897	PRSS3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains on...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPY-04683	CD47 Protein, Human, Recombinant	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-03763	Neuropilin-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3.
TMPY-06986	FGF-8b Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
TMPY-00132	Mesothelin Protein, Human, Recombinant	Human	HEK293 Cells
	Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His)	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
TMPY-04298	CDCP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3.
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His)	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3.
TMPY-01180	CD86 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3.
TMPY-00480	NCAM1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells)	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bi...
TMPY-05246	CD86 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	CD86 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P42081-3.
TMPY-03621	EphB2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.6 kDa and the accession number is P54763-3.
TMPY-00276	PLGF/PGF Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PLGF/PGF Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P49763-3.
TMPY-05514	RANK/TNFRSF11A Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3.
TMPY-03960	COL9A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	COL9A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is P20849-3.
TMPY-04386	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)	Human	Baculovirus Insect Cells
	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.2 kDa and the accession number is P29323-3.
TMPY-02691	IL-17RC Protein, Human, Recombinant(aa 1-454, hFc)	Human	HEK293 Cells
	IL-17RC Protein, Human, Recombinant(aa 1-454, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.3 kDa and the accession number is Q8NAC3-3.
TMPY-03435	NCKIPSD Protein, Human, Recombinant (GST)	Human	E. coli
	NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an importa...
TMPJ-00054	PLGF-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF f...
TMPJ-00391	FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)	Human	HEK293 Cells
	FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
TMPK-00398	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)	Human	HEK293 Cells
	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPJ-01288	KLF6 Protein, Human, Recombinant	Human	E. coli
	Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by ...
TMPY-03883	CD47 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is Q08722-3.
TMPY-06411	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3.
TMPY-01656	VEGF183 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3.
TMPY-05383	NKp30/NCR3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3.
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...
TMPY-04273	FGFR2 Protein, Human, Recombinant (aa 1-378, His)	Human	HEK293 Cells
	FGFR2 Protein, Human, Recombinant (aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41.1 kDa and the accession number is P21802-3.
TMPY-05590	NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 67.9 kDa and the accession number is P13591-3.
TMPY-04157	RANK/TNFRSF11A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is Q9Y6Q6-3.
TMPY-03969	SUSD4 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and ...
TMPJ-00390	FGFR2IIIb Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	FGFR2IIIb Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-90 KDa and the accession number is P21802-3.
TMPK-00399	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated	Human	HEK293 Cells
	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPJ-00899	HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc)	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 65 KDa and the accession number is P21860-3.
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc)	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPY-04216	EphB2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is P54763-3.
TMPY-05602	GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.1 kDa and the accession number is Q9Y5U5-3.
TMPY-04015	COL9A1 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	COL9A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 59.2 kDa and the accession number is P20849-3.
TMPY-01692	NETO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...
TMPY-00715	CD84 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD84 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9UIB8-3.
TMPY-05233	GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
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