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カタログ番号	製品名	別名	ターゲット
T37596	Terevalefim		c-Met/HGFR
	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.		c-Met/HGFR
T7376	Dihexa	PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide	c-Met/HGFR
	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.		c-Met/HGFR
T39507L	Fosgonimeton acetate	Fosgonimeton acetate (2093305-05-4 Free base)	c-Met/HGFR
	Fosgonimeton acetate is an agonist of hepatocyte growth factor (HGF).		c-Met/HGFR
T76780	Onartuzumab	RG-3638,PRO-14396,MetMAb	c-Met/HGFR
	Onartuzumab (MetMAb) is a humanized anti-tyrosine kinase c-MET monovalent monoclonal antibody.Onartuzumab has antitumor activity with inhibitory effects on HGF binding, receptor phosphorylation, and signal transduction.		c-Met/HGFR
T76758	Rilotumumab	AMG 102	c-Met/HGFR
	Rilotumumab (AMG 102) is a monoclonal antibody targeting hepatocyte growth factor that inhibits HGF/ MET-driven signaling. Rilotumumab has antitumor effects and can be used to study castration-resistant prostate cancer (...		c-Met/HGFR
T5478	SRI 31215 TFA	SRI 31215	c-Met/HGFR
	SRI 31215 TFA, a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation with IC50s of 0.69 μM, 0.65 μM, 0.3 μM,		c-Met/HGFR
T76743	Emibetuzumab	LY2875358	c-Met/HGFR
	Emibetuzumab is a potent humanized bivalent MET antibody (IgG4 type). Emibetuzumab has antitumor activity, inhibition of HGF-dependent and independent MET pathway activation and tumor growth, and can be used to study adv...		c-Met/HGFR
T8416	Capmatinib xHCl	INCB28060,Capmatinib hydrochloride(free base),INC280	c-Met/HGFR
	Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activit...		c-Met/HGFR
T2054	Altiratinib	DCC-2701	VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist...		VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
T19389	L-Ascorbic acid 2-phosphate magnesium	2-Phospho-L-ascorbic acid magnesium	Phosphatase , Phosphorylase
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivative that can stimulate...		Phosphatase , Phosphorylase
T74390	VD2173
	VD2173, a macrocyclic peptide inhibitor with a side chain cyclization, effectively inhibits HGF-activating serine proteases including matriptase and hepsin, and is utilized in lung cancer research [1].
TP1990	Norleual
	Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
T76745	Ficlatuzumab
	Ficlatuzumab, a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF), impedes the HGF/c-Met signaling pathway. By blocking this pathway, it prevents c-Met receptor-mediated cancer cell proliferation,...
T28899	T-1840383
	T-1840383 is an inhibitor of VEGF-induced VEGFR-2 phosphorylation and HGF-induced c-Met phosphorylation in vascular endothelial cells and cancer epithelial cells.
T70318	AMG-337 monohydrate
	AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive th...
T70844	CM-118
	CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ...
T75940	Norleual TFA
	Norleual TFA, an analog of angiotensin (Ang) IV, functions as a hepatocyte growth factor (HGF)/c-Met inhibitor, displaying a potent inhibition capability with an IC50 of 3 pM. Additionally, it acts as an AT4 receptor ant...
T28240	Ono 1301	Ono-1301,Ono1301
	Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only wit...
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascul...
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vas...
T78549	Ethylene glycol dimethacrylate		Reactive Oxygen Species
	Ethylene glycol dimethacrylate, a methacrylate monomer, demonstrates cytotoxic and genotoxic impacts on human gingival fibroblasts (HGFs), elevating intracellular reactive oxygen species (ROS) levels, inducing DNA damage...		Reactive Oxygen Species

Compounds

Synonym: PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide

Target: c-Met/HGFR

Fosgonimeton acetate

T39507L

Synonym: Fosgonimeton acetate (2093305-05-4 Free base)

Target: c-Met/HGFR

Onartuzumab

T76780

Synonym: RG-3638,PRO-14396,MetMAb

Synonym: INCB28060,Capmatinib hydrochloride(free base),INC280

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

L-Ascorbic acid 2-phosphate magnesium

T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium

Target: Phosphatase, Phosphorylase

Synonym: Ono-1301,Ono1301

Ethylene glycol dimethacrylate

T78549

Synonym:

Target: Reactive Oxygen Species

カタログ番号	製品名	ターゲット
T5S1331	Herbacetin	c-Met/HGFR , Akt
	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.	c-Met/HGFR , Akt
TN4023	Eucalyptin	Antifection
	Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A ex...	Antifection
TN2177	Sanggenol L	c-Myc , NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± ph...	c-Myc , NF-κB
TN1549	Damnacanthal	IL Receptor , Akt , Syk
	Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.	IL Receptor , Akt , Syk

天然物製品

Herbacetin

T5S1331

Synonym:

Target: c-Met/HGFR, Akt

Target: IL Receptor, Akt, Syk

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03290	HGF Protein, Mouse, Recombinant	Mouse	HEK293 Cells
	HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.
TMPJ-00375	HGF Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPK-00369	HGF Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different i...
TMPY-02327	HGF Protein, Human, Recombinant	Human	CHO Cells
	HGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 79.7 kDa and the accession number is P14210-1.
TMPY-03237	HGF Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
TMPY-00863	IL-6 Protein, Human, Recombinant	Human	E. coli
	IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.
TMPY-00456	HGF Protein, Canine, Recombinant	Canine	HEK293 Cells
	HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7.
TMPY-03246	HGF Protein, Rat, Recombinant	Rat	HEK293 Cells
	HGF Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is A6K5E8.
TMPY-03545	HGF Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293 Cells
	HGF Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.6 kDa and the accession number is C9E9X5.
TMPH-03312	HGF Protein, Rat, Recombinant (GST)	Rat	E. coli
	Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase M...
TMPK-01219	HGFA Protein (pro form), Mouse, Recombinant (His)	Mouse	HEK293 Cells
	HGFA Protein (pro form), Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.9 kDa and the accession number is Q9R098.
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain ...
TMPK-00484	HGFA Protein (pro form), Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	HGFA Protein (pro form), Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.47 kDa and the accession number is A0A2K5TZH3.
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain ...
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un...
TMPY-01895	HGFR/c-Met Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128 kDa and the accession number is A4FUV6.
TMPK-00101	IL-6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 recep...
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
TMPY-00821	HGFA Protein (pro form), Human, Recombinant (His)	Human	HEK293 Cells
	HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the act...
TMPY-03581	HGFR/c-Met Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.1 kDa and the accession number is Q2IBC7.
TMPY-05441	HGFR/c-Met Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.4 kDa and the accession number is A0A024R759.
TMPY-00718	HGFR/c-Met Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 129.5 kDa and the accession number is A0A024R759.
TMPY-00546	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 128.3 kDa and the accession number is G7MM61.
TMPY-04379	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)	Human	Baculovirus Insect Cells
	HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
TMPY-02068	HGFR/c-Met Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	HGFR/c-Met Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is Q75ZY9.
TMPY-06278	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is NP_001162100.2.
TMPY-00634	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 102.3 kDa and the accession number is G7MM61.
TMPY-05607	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 104.9 kDa and the accession number is A0A024R759.
TMPY-06657	HGFR/c-Met Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	HGFR/c-Met Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102.53 kDa and the accession number is XP_006236191.1.
TMPJ-00059	IL-7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions...
TMPH-02922	SRPX2 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration...
TMPH-02923	SRPX2 Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration...
TMPY-01412	Glypican 5 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Glypican-5 (GPC5), is a cell membrane protein that belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...