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Search Results for " IL-12 "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T21694	(R)-Lisofylline	(R)-Lisophylline	STAT
	(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat...		STAT
T3533	Apilimod mesylate	STA 5326 mesylate	IL Receptor , PI3K , Interleukin
	Apilimod mesylate (STA 5326 mesylate) is a potent IL-12/IL-23 inhibitor.		IL Receptor , PI3K , Interleukin
T9913	Ustekinumab		Interleukin
	Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.		Interleukin
T2018	Apilimod	STA 5326	IL Receptor , PI3K , Interleukin
	Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.		IL Receptor , PI3K , Interleukin
T28958	TG6-129	TG6 129	Prostaglandin Receptor
	TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and...		Prostaglandin Receptor
T14687	Deucravacitinib	BMS-986165	Tyrosine Kinases , JAK , IFNAR , Interleukin
	Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively bi...		Tyrosine Kinases , JAK , IFNAR , Interleukin
T7649	Tyrphostin A1	AG9,Tyrphostin 1	EGFR , Interleukin
	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .		EGFR , Interleukin
T2061	APY0201		PI3K , Interleukin
	APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3, 5)P2.		PI3K , Interleukin
T38294	4-Deoxypyridoxine hydrochloride		S1P Receptor
	4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib...		S1P Receptor
T76935	Briakinumab
	Briakinumab (ABT-874), a fully human anti-IL-12/23p40 monoclonal antibody, selectively targets and neutralizes IL-12 and IL-23. This compound is utilized in the research of various autoimmune disorders, including rheumat...
T26280	TL4-12	TL4 12
	TL4-12 is a MAP4K2 (GCK) inhibitor that inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro.
TP1978	11R-VIVIT	NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ...
T78175	JAK-IN-25		JAK
	JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-1...		JAK
T70394	Deucravacitinib HCl
	Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bo...
T62451	TYK2-IN-12
	TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM). TYK2-IN-12 inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respec...
T73034	NLRP3-IN-12
	NLRP3-IN-12 is a specific inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release by targeting the NLRP3 protein, and demonstrating an IC50 of 0.45 μM. This compound is utilized in the research of inflamm...
T40123	BMS-986251
	BMS-986251 is a potent and specific RORγt inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for RORγt GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with ...
T74971	Diamino lipid DAL4
	Diamino lipid DAL4 is novel lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12 , IL-27 and GM-CSF . Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity [1] .
T76602	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a corticotropin-releasing factor (CRF) antagonist known to counteract the inhibitory effects of IL-1a on Luteinizing hormone (LH) production [1].
T83866	LCC-12 formate
	LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At...
T62803	STAT3-IN-12
	STAT3-IN-12 is a potent inhibitor of STAT3 signalling and inhibits IL-6-induced activation of the JAK/STAT3 signalling pathway. STAT3-IN-12 inhibits the growth and migration of cancer cells, blocks the cell cycle and ind...
T81331	QL-1200186		JAK
	QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following interleukin-12 (IL-12) stimulation and markedly improves skin le...		JAK
T22172	YS-121
	YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s...
T78762	SIKs-IN-1
	SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK...
T78508	Delmitide acetate	RDP-58 acetate	IFNAR
	Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties. This compound suppresses the production of TNF-α, IFN-γ, and interleukin (IL)-12, while enhancing the ...		IFNAR
T37564	C4 Ceramide (d18:1/4:0)	C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used...
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits c...
T36320	C6 L-threo Ceramide (d18:1/6:0)	C6 L-threo Ceramide (d18:1/6:0)
	C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik...
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo...
T36998	7β,27-dihydroxy Cholesterol	7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res...
T64280	ODN 2216
	ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist that induces the production of large amounts of IFN-α and IFN-β. ODN 2216 can induce IFN-α using pDC (plasma cell-like DC) and IL-12 (p40) using DC (dendritic c...
T35927	C2 L-threo Ceramide (d18:1/2:0)	C2 L-threo Ceramide (d18:1/2:0)
	C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o...
T23028	MRT67307 HCl (1190378-57-4 free base)	MRT67307 HCl	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...		Others
T37565	C6 D-threo Ceramide (d18:1/6:0)	C6 D-threo Ceramide (d18:1/6:0)
	C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at...
T68306	INCB16562
	INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced p...
T36713	Streptochlorin
	Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cari...
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f...

Compounds

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Synonym: (R)-Lisophylline

Target: STAT

Apilimod mesylate

T3533

Synonym: STA 5326 mesylate

Target: IL Receptor, PI3K, Interleukin

Target: IL Receptor, PI3K, Interleukin

TG6-129

T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Deucravacitinib

T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Tyrphostin A1

T7649

Synonym: AG9,Tyrphostin 1

Target: EGFR, Interleukin

APY0201

T2061

Synonym:

Target: PI3K, Interleukin

4-Deoxypyridoxine hydrochloride

Synonym: NFAT inhibitor, Cell Permeable

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)

Synonym: RDP-58 acetate

Target: IFNAR

C4 Ceramide (d18:1/4:0)

T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

C6 L-threo Ceramide (d18:1/6:0)

T36320

Synonym: C6 L-threo Ceramide (d18:1/6:0)

7β,27-dihydroxy Cholesterol

T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

C2 L-threo Ceramide (d18:1/2:0)

T35927

Synonym: C2 L-threo Ceramide (d18:1/2:0)

Target:

MRT67307 HCl (1190378-57-4 free base)

T23028

Synonym: MRT67307 HCl

Target: Others

C6 D-threo Ceramide (d18:1/6:0)

T37565

Synonym: C6 D-threo Ceramide (d18:1/6:0)

β-Defensin-4 (human) (trifluoroacetate salt)

β-Defensin-2 (human) (trifluoroacetate salt)

T35451

Synonym:

Target:

Tucatinib hemiethanolate

T36648

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T3765	L-asarinin	(-)-Episesamin	Others
	L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he...		Others
TN1787	Isomucronulatol 7-O-glucoside	Isomucronulatol 7-O-beta-glucoside	Others
	Isomucronulatol 7-O-glucoside is a natural product		Others
T3859	Isomucronulatol	7,2'-Dihydroxy-3',4'-dimethoxyisoflavan	Others
	Isomucronulatol (7,2'-Dihydroxy-3',4'-dimethoxyisoflavan) is a natural product		Others
TN1189	13-Methylberberine chloride	13-Methylberberine	Others
	13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug		Others
TN4190	Hedycoronen A		IL Receptor , TNF
	Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also sh...		IL Receptor , TNF
T16733	Resolvin E1	RvE1	Others
	Resolvin E1 is an effective endogenous pro-resolving mediator of inflammation. Resolvin E1 has unique counterregulatory actions that inhibit PMN transendothelial migration. Resolvin E1 also acts as an effective inhibitor...		Others
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the pa...

天然物製品

L-asarinin

T3765

Synonym: (-)-Episesamin

Target: Others

Isomucronulatol 7-O-glucoside

TN1787

Synonym: Isomucronulatol 7-O-beta-glucoside

Target: Others

Isomucronulatol

T3859

Synonym: 7,2'-Dihydroxy-3',4'-dimethoxyisoflavan

Target: Others

13-Methylberberine chloride

TN1189

Synonym: 13-Methylberberine

Target: IL Receptor, TNF

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04863	IL-12 Protein, Human, Recombinant	Human	HEK293
	IL-12 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 57.2 kDa. Accession number: P29459-1&NP_002178.2
TMPY-01767	IL-12RB2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleu...
TMPY-02350	IL-12 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.3 kDa. Accession number: P43431&P43432
TMPY-01701	IL-12RB1 Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-02109	IL-12 Protein, Human, Recombinant (His)	Human	HEK293
	IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459-1&NP_002178.2
TMPY-05458	IL-12 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459.2&NP_002178.2
TMPJ-00398	IL-12RB2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits tha...
TMPJ-00363	IL-12RB1 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL1...
TMPY-02349	IL-12 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 111.5 kDa. Accession number: P43431&P43432
TMPY-03725	IL-12 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IL-12 Protein, Rhesus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.2 kDa. Accession number: NP_001038199.1&NP_001038190.1
TMPK-01378	IL-12B Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3....
TMPY-06662	IL-12RB1 Protein, Human, Recombinant	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-02351	IL-12 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 with His and hFc tag. The predicted molecular weight is 85.9 kDa. Accession number: P43431&P43432
TMPJ-00216	IL-12B Protein, Human, Recombinant	Human	Human Cells
	Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, a...
TMPY-04874	IL-23 P19/IL23A Protein, Human, Recombinant (hFc)	Human	HEK293
	IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t...
TMPY-01872	IL-28B Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda...
TMPY-03142	IL-27 Protein, Human, Recombinant (His)	Human	CHO
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03516	IL-12B Protein, Mouse, Recombinant	Mouse	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-01045	IL-12B Protein, Human, Recombinant (His)	Human	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-03198	IL-12B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-01928	IL-18 Protein, Rhesus, Recombinant (His)	Rhesus	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-03273	IL-18 Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-00277	IL-18 Protein, Human, Recombinant	Human	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g...
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain)	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPY-00856	TCCR Protein, Human, Recombinant (hFc)	Human	HEK293
	The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit, and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor th...
TMPY-01107	TIMP-1 Protein, Human, Recombinant	Human	HEK293
	TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibi...
TMPY-04987	IL-23 P19/IL23A Protein, Human, Recombinant (mFc)	Human	HEK293
	IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t...
TMPK-00076	IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated	Human	E. coli
	Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop...
TMPK-01094	IL-23R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00652	IL-23R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00575	IL-23R Protein, Canine, Recombinant (His)	Canine	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00353	IL-23R Protein, Human, Recombinant (aa 24-355, His)	Human	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00512	IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)	Cynomolgus	HEK293
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00317	IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPY-00454	IL-28B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda...
TMPK-00316	IL-18R alpha Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPY-01409	IL-12A Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-00838	IL-12A Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-04105	IL-12A Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63...
TMPY-03309	IL-12B Protein, Rat, Recombinant (His)	Rat	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-02366	IL-12B Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-00259	IL-12B Protein, Rabbit, Recombinant (His)	Rabbit	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-06428	IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293
	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleu...
TMPY-00458	IL-12B Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-03671	IL-12B Protein, Marmoset, Recombinant (hFc)	Marmoset	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-00839	IL-12B Protein, Human, Recombinant (hFc)	Human	HEK293
	Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts...
TMPY-06427	IL-12RB1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I tra...
TMPY-02583	IL-1F8 Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines inclu...
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IL-12 Protein, Human, Recombinant

TMPY-04863

Species: Human

Expression System: HEK293

IL-12RB2 Protein, Mouse, Recombinant (His)

TMPY-01767

Species: Mouse

Expression System: HEK293

IL-12 Protein, Mouse, Recombinant (His)

TMPY-02350

Species: Mouse

Expression System: HEK293

IL-12RB1 Protein, Human, Recombinant (His)

TMPY-01701

Species: Human

Expression System: HEK293

IL-12 Protein, Human, Recombinant (His)

TMPY-02109

Species: Human

Expression System: HEK293

IL-12 Protein, Human, Recombinant (His), Biotinylated

TMPY-05458

Species: Human

Expression System: HEK293

IL-12RB2 Protein, Mouse, Recombinant (hFc)

TMPJ-00398

Species: Mouse

Expression System: Human Cells

IL-12RB1 Protein, Human, Recombinant (hFc)

TMPJ-00363

Species: Human

Expression System: Human Cells

IL-12 Protein, Mouse, Recombinant (hFc)

TMPY-02349

Species: Mouse

Expression System: HEK293

IL-12 Protein, Rhesus, Recombinant (His)

TMPY-03725

Species: Rhesus

Expression System: HEK293

IL-12B Protein, Cynomolgus, Recombinant (His)

TMPK-01378

Species: Cynomolgus

Expression System: HEK293

IL-12RB1 Protein, Human, Recombinant

TMPY-06662

Species: Human

Expression System: HEK293

IL-12 Protein, Mouse, Recombinant (His & hFc)

TMPY-02351

Species: Mouse

Expression System: HEK293

IL-12B Protein, Human, Recombinant

TMPJ-00216

Species: Human

Expression System: Human Cells

IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

TMPY-04874

Species: Human

Expression System: HEK293

IL-28B Protein, Human, Recombinant (His)

TMPY-01872

Species: Human

Expression System: HEK293

IL-27 Protein, Human, Recombinant (His)

TMPY-03142

Species: Human

Expression System: CHO

IL-27 Protein, Mouse, Recombinant (His)

TMPY-03153

Species: Mouse

Expression System: HEK293

IL-12B Protein, Mouse, Recombinant

TMPY-03516

Species: Mouse

Expression System: HEK293

IL-12B Protein, Human, Recombinant (His)

TMPY-01045

Species: Human

Expression System: HEK293

IL-12B Protein, Mouse, Recombinant (His)

TMPY-03198

Species: Mouse

Expression System: HEK293

IL-18 Protein, Rhesus, Recombinant (His)

TMPY-01928

Species: Rhesus

Expression System: E. coli

IL-18 Protein, Mouse, Recombinant

TMPY-03273

Species: Mouse

Expression System: E. coli

IL-18 Protein, Human, Recombinant

TMPY-00277

Species: Human

Expression System: E. coli

MMP-12 Protein, Human, Recombinant (catalytic domain)

TMPY-02869

Species: Human

Expression System: E. coli

TCCR Protein, Human, Recombinant (hFc)

TMPY-00856

Species: Human

Expression System: HEK293

TIMP-1 Protein, Human, Recombinant

TMPY-01107

Species: Human

Expression System: HEK293

IL-23 P19/IL23A Protein, Human, Recombinant (mFc)

TMPY-04987

Species: Human

Expression System: HEK293

IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated

TMPK-00076

Species: Human

Expression System: E. coli

IL-23R Protein, Mouse, Recombinant (His)

TMPK-01094

Species: Mouse

Expression System: HEK293

IL-23R Protein, Cynomolgus, Recombinant (His)

TMPK-00652

Species: Cynomolgus

Expression System: HEK293

IL-23R Protein, Canine, Recombinant (His)

TMPK-00575

Species: Canine

Expression System: HEK293

IL-23R Protein, Human, Recombinant (aa 24-355, His)

TMPK-00353

Species: Human

Expression System: HEK293

IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)

TMPK-00512

Species: Cynomolgus

Expression System: HEK293

IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00317

Species: Human

Expression System: HEK293

IL-28B Protein, Mouse, Recombinant (His)

TMPY-00454

Species: Mouse

Expression System: HEK293

IL-18R alpha Protein, Human, Recombinant (His & Avi)

TMPK-00316

Species: Human

Expression System: HEK293

IL-12A Protein, Human, Recombinant (His)

TMPY-01409

Species: Human

Expression System: HEK293

IL-12A Protein, Human, Recombinant (hFc)

TMPY-00838

Species: Human

Expression System: HEK293

IL-12A Protein, Rhesus, Recombinant (hFc)

TMPY-04105

Species: Rhesus

Expression System: HEK293

IL-18 Protein, Mouse, Recombinant (His)

TMPJ-01056

Species: Mouse

Expression System: E. coli

IL-12B Protein, Rat, Recombinant (His)

TMPY-03309

Species: Rat

Expression System: HEK293

IL-12B Protein, Mouse, Recombinant (hFc)

TMPY-02366

Species: Mouse

Expression System: HEK293

IL-12B Protein, Rabbit, Recombinant (His)

TMPY-00259

Species: Rabbit

Expression System: HEK293

IL-12RB2 Protein, Cynomolgus, Recombinant (mFc)

TMPY-06428

Species: Cynomolgus

Expression System: HEK293

IL-12B Protein, Rat, Recombinant (hFc)

TMPY-00458

Species: Rat

Expression System: HEK293

IL-12B Protein, Marmoset, Recombinant (hFc)

TMPY-03671

Species: Marmoset

Expression System: HEK293

IL-12B Protein, Human, Recombinant (hFc)

TMPY-00839

Species: Human

Expression System: HEK293

IL-12RB1 Protein, Cynomolgus, Recombinant (His)

TMPY-06427

Species: Cynomolgus

Expression System: HEK293

IL-1F8 Protein, Mouse, Recombinant

TMPY-02583

Species: Mouse

Expression System: E. coli

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カタログ番号	製品名
L3800	NF-κB Signaling Compound Library		729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;

ライブラリー

NF-κB Signaling Compound Library

L3800

Compounds: 729