|
T9610 |
PARP1-IN-5 dihydrochloride
|
|
PARP
|
|
PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. |
|
T9891 |
PARP1-IN-8
|
N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide |
PARP
|
|
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM). |
|
T39139 |
PARP1-IN-6
|
PARP1-IN-6 |
|
|
PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM for PARP-1. |
|
T72437 |
PARP1/2/TNKS1/2-IN-1
|
|
Apoptosis
,
PARP
,
Wnt/beta-catenin
|
|
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis. |
|
T13845 |
PROTAC PARP1 degrader
|
|
Others
|
|
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM). |
|
T81543 |
PARP1-IN-17
|
|
PARP
|
|
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis. It exhibits robust anti-proliferative activity [1]. |
|
T79405 |
PARP1-IN-15
|
|
PARP
|
|
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ... |
|
T60637 |
PARP1-IN-11
|
|
|
|
PARP1-IN-11 (compound 49) is a potent inhibitor of PARP1 with IC50 value of 0.082 μM which shows complete inhibition of PARP1 and substantially inhibits PARP3, TNKS1 and TNKS2 [1]. |
|
T73023 |
PARP1-IN-12
|
|
|
|
PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces... |
|
T62955 |
PARP1-IN-5
|
|
|
|
PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research. |
|
T81544 |
PARP1-IN-16
|
|
PARP
|
|
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM. It possesses the capability to halt the cell cycle at the S phase and stimulate apoptosis in HCT-116 cells [1]. |
|
T79593 |
PARP1-IN-14
|
|
PARP
|
|
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with ... |
|
T61879 |
PARP1-IN-7
|
|
|
|
PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1). |
|
T61325 |
PARP1-IN-9
|
|
|
|
PARP1-IN-9 (Compound 5c) is a potent PARP1 inhibitor, displaying an IC 50 of 30.51 nM. With its ability to induce cell apoptosis and exhibit anticancer activity, PARP1-IN-9 surpasses Olaparib in terms of efficacy [1]. |
|
T61694 |
PARP1-IN-10
|
|
|
|
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while a... |
|
T63471 |
PARP1/BRD4-IN-1
|
|
|
|
PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the ma... |
|
T62540 |
PARP1/BRD4-IN-2
|
|
|
|
PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-... |
|
T8806 |
Fluzoparib
|
HS10160,SHR3162 |
PARP
|
|
Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours. |
|
T7539 |
O6-Benzylguanine
|
|
Apoptosis
,
DNA Alkylation
,
DNA/RNA Synthesis
|
|
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
|
T12412L |
PDK4-IN-1 hydrochloride
|
|
Apoptosis
,
PDK
|
|
|
|
T3015 |
Olaparib
|
AZD2281,KU0059436 |
Mitophagy
,
PARP
,
Autophagy
|
|
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m... |
|
T72553 |
ARTD10/PARP10-IN-1
|
|
PARP
|
|
ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activit... |
|
T67932 |
PARP10-IN-3
|
|
PARP
|
|
PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 and human PARP15 with IC50 values of 1.7 μM. |
|
T73007 |
PARP10-IN-2
|
|
PARP
|
|
PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and PARP15, with IC50 values of 27 μM and 11 μM, respectively. |
|
T72554 |
ARTD10/PARP10-IN-2
|
|
|
|
ARTD10/PARP10-IN-2 is a potent, non-selective inhibitor of mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1, exhibiting IC50 values of 2.0 μM and 9.7 μM, respectively. |
|
T12366 |
PARP14 inhibitor H10
|
|
PARP
|
|
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM |
|
T60495 |
PARP10/15-IN-1
|
|
|
|
PARP10/15-IN-1 (compound 8l) is a dual PARP10 and PARP15 inhibitor with IC50s of 160 nM and 370 nM, respectively. It can be used in cancer research[1]. |
|
T60567 |
PARP10/15-IN-2
|
|
|
|
PARP10/15-IN-2 (Compound 8h) is a dual inhibitor of PARP10 and PARP15 with IC 50 values of 0.15 μM and 0.37 μM, respectively. PARP10/15-IN-2 can enter cells and rescue cells from apoptosis [1]. |
|
T60309 |
PARP10/15-IN-3
|
|
|
|
PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC 50 values of 0.14 μM and 0.40 μM against PARP10 and PARP15, respectively. PARP10/15-IN-3 can enter cells and rescue cells from apoptosis [... |
|
T72397 |
PARP11 inhibitor ITK7
|
ITK7 |
|
|
PARP11 Inhibitor ITK7 (ITK7) is a potent, selective inhibitor of PARP11, demonstrating significant efficacy with an IC50 value of 14 nM. It is primarily utilized in research focused on cellular localization. |
|
T7896 |
BYK204165
|
RT-017290 |
PARP
|
|
BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay) |
|
T12064 |
Niraparib (R-enantiomer)
|
MK 4827 (R-enantiomer),Niraparib R-enantiomer |
PARP
|
|
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
|
T7042 |
1,5-Isoquinolinediol
|
|
PARP
|
|
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... |
|
T6892 |
Niraparib tosylate
|
MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate |
Apoptosis
,
PARP
|
|
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. |
|
T6366 |
A-966492
|
|
PARP
|
|
A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively. |
|
T2105 |
Veliparib dihydrochloride
|
ABT-888 dihydrochloride |
PARP
,
Autophagy
|
|
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
|
T4471 |
E7449
|
Stenoparib,UNII-9X5A2QIA7C |
Others
,
PARP
|
|
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. |
|
T22988 |
MK-4827 Racemate
|
Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide |
PARP
|
|
MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1. |
|
T62281 |
PARP-1-IN-2
|
|
PARP
|
|
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel... |
|
T9430 |
Venadaparib
|
NOV140101,IDX-1197 |
PARP
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... |
|
T6339 |
AG14361
|
AG 14361,AG-14361 |
PARP
|
|
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM). |
|
T3231 |
Niraparib
|
MK-4827 |
Apoptosis
,
Others
,
PARP
|
|
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. |
|
T16807 |
Rucaparib monocamsylate
|
Rucaparib Camsylate |
PARP
|
|
Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. |
|
T6253 |
Talazoparib
|
LT-673,BMN-673 |
PARP
|
|
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). |
|
T2591 |
Veliparib
|
ABT-888,NSC 737664 |
PARP
,
Autophagy
|
|
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy. |
|
T63228 |
Simmiparib
|
SMOCL-9112 |
Apoptosis
,
PARP
|
|
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... |
|
T4463 |
Rucaparib
|
AG-14447,PF-01367338,AG014699 |
PARP
|
|
Rucaparib (PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP. |
|
T9593 |
Senaparib
|
IMP4297 |
PARP
|
|
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity. |
|
T50044 |
5-AIQ
|
|
PARP
|
|
5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1. |
|
T50098 |
TIQ-A
|
|
PARP
|
|
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... |
