|
T3518 |
GSK269962A
|
GSK269962B,GSK 269962,GSK269962A HCl |
ROCK
,
S6 Kinase
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
|
T12746 |
ROCK inhibitor-2
|
|
ROCK
|
|
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively). |
|
T4276 |
Hydroxyfasudil Hydrochloride
|
Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride |
ROCK
|
|
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
|
T4276L |
Hydroxyfasudil
|
Hydroxy-Fasudil,HA-1100 |
ROCK
,
PKA
|
|
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively). |
|
T2633 |
GSK429286A
|
RHO-15 |
ROCK
|
|
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). |
|
T1898 |
RKI-1447
|
RKI1447 |
ROCK
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
|
T1606 |
Fasudil
|
HA-1077,AT877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. |
|
T9847 |
TLC2976-0103
|
|
|
|
ROCK1-IN-1 is an inhibitor of ROCK1 with a K i value of 540 nM. ROCK1-IN-1 can be used in the research of hypertension, glaucoma and erectile dysfunction [1]. |
|
TQ0319 |
Ripasudil
|
K-115,Ripasudil hydrochloride dihydrate |
ROCK
|
|
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2). |
|
T3060 |
Fasudil hydrochloride
|
Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
HIV Protease
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. |
|
T27471 |
GSK299115A
|
GSK 299115A,GSK-299115A |
GRK
|
|
GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively. |
|
T14960 |
Chroman 1
|
|
ROCK
|
|
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). |
|
T7301 |
BDP5290
|
|
ROCK
|
|
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) |
|
T27467 |
GSK270822A
|
GSK 270822A,GSK-270822A |
GRK
|
|
GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively. |
|
T3513 |
GSK180736A
|
GSK180736 |
ROCK
,
GRK
,
PKA
|
|
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM). |
|
T12721 |
Rho-Kinase-IN-1
|
|
ROCK
|
|
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... |
|
T11402L |
GKI-1 HCl
|
GKI-1 HCl（ 2444764-03-6 Free base） |
ROCK
|
|
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant. |
|
T11402 |
GKI-1
|
|
Others
|
|
GKI-1 is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL with an IC50 of 4.9. GKI-1 also inhibited hGWL-KinDom, and its IC50 was 2.5 µM. The inhibitory effect of GKI-1 on ROCK1 was better than that of hGWLFL and ... |
|
T60924 |
Verosudil
|
AR-12286 |
ROCK
|
|
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... |
|
T22037 |
AS 1892802
|
|
ROCK
|
|
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 ... |
|
T1828 |
TTP 22
|
|
Casein Kinase
|
|
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM). |
|
T6867 |
Belumosudil
|
KD025,Rezurock,ROCK inhibitor,SLx-2119 |
ROCK
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
|
T4488 |
GSK-25
|
GSK25 |
ROCK
,
S6 Kinase
,
mTOR
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
T16855 |
SB-772077B dihydrochloride
|
|
ROCK
|
|
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively). |
|
T39555 |
Belumosudil mesylate
|
SLx-2119mesylate,KD025 mesylate |
|
|
Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties. |
|
TQ0187 |
SR-3677
|
|
ROCK
,
Autophagy
|
|
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). |
|
T7391 |
SAR407899
|
|
ROCK
,
Rho
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
|
T39519 |
GSK269962A hydrochloride
|
GSK 269962 hydrochloride |
|
|
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inf... |
|
T39944 |
HSD1590
|
|
|
|
HSD1590 is a highly effective and potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.22 nM and 0.51 nM, respectively. It demonstrates exceptional binding affinity to ROCK, with Kd values below 2 nM. Moreover, HSD... |
|
T61905 |
RKI-1447 dihydrochloride
|
|
|
|
RKI 1447 dihydrochloride is an effective and selective ROCK inhibitor (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM). RKI 1447 dihydrochloride can inhibit the growth of colorectal cancer cells and promote cell apoptosis. |
|
T23308 |
SAR407899 hydrochloride
|
|
ROCK
|
|
ATP-competitive ROCK inhibitor |
|
T10275 |
AKT-IN-3
|
|
Akt
|
|
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin... |
|
T63506 |
Chroman 1 dihydrochloride
|
|
|
|
Chroman 1 dihydrochloride is a selective and potent inhibitor of ROCK, acting more strongly on ROCK2 (IC50: 1 pM) than ROCK1 (IC50: 52 pM) and also inhibiting MRCK activity (IC50: 150 nM). |
|
T74808 |
THK01
|
|
|
|
THK01, a potent ROCK2 inhibitor, exhibits IC50 values of 5.7 nM for ROCK2 and 923 nM for ROCK1, respectively. It effectively targets the ROCK2-STAT3 signaling pathway to inhibit breast cancer metastasis, making it valuab... |
|
TQ0110 |
ROCK-IN-2
|
TC-S 7001,Azaindole 1 |
ROCK
|
|
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. |
|
T61382 |
Fasudil dihydrochloride
|
|
|
|
Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 μM, as well as ROCK2, PKA, PKC... |
|
T1725 |
Y-27632 dihydrochloride
|
Y-27632 2HCl |
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
|
T71119 |
Netarsudil free base
|
|
|
|
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Hum... |
|
T7492 |
Ripasudil free base
|
K-115 (free base) |
ROCK
,
Antibacterial
|
|
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent. |
|
T2482 |
AT13148
|
|
ROCK
,
SGK
,
Akt
,
PKA
,
S6 Kinase
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
|
T39733 |
Hu7691 free base
|
|
Akt
|
|
Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ... |
|
T15428 |
Uprosertib hydrochloride
|
GSK2141795 (hydrochloride) |
Others
|
|
Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively). |
|
T39899 |
Hu7691
|
|
Akt
|
|
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces differentiation of neuroblastoma cells. |
