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T9127 |
MYLS22
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|
Others
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|
MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp... |
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T1536 |
Promestriene
|
3-propyl ethyl,17B-methyl estradiol,Promestriano |
Estrogen/progestogen Receptor
|
|
Promestriene (3-propyl ethyl) (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic. |
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T16545 |
Pivanex
|
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis
,
HDAC
,
Bcr-Abl
|
|
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis. |
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T4641 |
Branaplam
|
LMI 070,NVS-SM1 |
Others
,
Potassium Channel
,
DNA/RNA Synthesis
|
|
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
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T27322 |
Fispemifene
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HM-101,HM 101,HM101 |
Others
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|
Fispemifene (HM-101) is an estrogen receptor modulator (SERM) used to treat genitourinary syndromes and vaginal atrophy. |
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T3336 |
Rg3039
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PF-06687859 |
Others
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|
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an... |
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T20802 |
Flumethasone pivalate
|
Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten |
Others
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|
Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang... |
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T12935 |
SMN-C3
|
MV8T2MCK57 |
DNA/RNA Synthesis
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|
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA). |
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T12718L |
RG7800
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RO6885247 |
Others
,
DNA/RNA Synthesis
|
|
RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier. |
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TP2373L |
Biotinoyl tripeptide-1 Acetate
|
Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base) |
Others
|
|
Biotinoyl tripeptide-1 Acetate can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging. |
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T77445 |
Apitegromab
|
SRK-015 |
Opioid Receptor
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|
Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal muscular atrophy. |
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T28273L |
OT-551 HCl
|
OT-551 HCl（627085-11-4 Free base） |
NF-κB
|
|
OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA). |
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T73475 |
SMN-C2
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|
DNA/RNA Synthesis
|
|
SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.SMN-C2 has the potential to be used in the... |
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T6620 |
Ospemifene
|
FC-1271a |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
|
|
Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA ap... |
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T33433 |
MK-3984
|
MK3984 |
|
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Mk-3984 is a selective androgen receptor modulator, which can be used to prevent and treat cancer-related muscle atrophy. |
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T31168 |
D153249
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D 153249,D-153249 |
|
|
D153249 is a promoter of spinal muscular atrophy (SMA). |
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TP2373 |
Biotinoyl tripeptide-1
|
Biotin GHK,BiotinGHK,Biotin-GHK |
|
|
Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging. |
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T19737 |
Perthane
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|
|
|
Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans,and also prevent the formation of spontaneous mammary carcinoma. |
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T34664 |
SMN2-Stablizer-27
|
SMN2-Stablizer 27,SMN2 Stablizer-27 |
|
|
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA). |
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T78236 |
MuRF1-IN-2
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|
Others
|
|
MuRF1-IN-2 (Example 3) serves as a MuRF1 inhibitor, applicable for investigating conditions associated with muscle wasting, including both skeletal and cardiac muscle atrophy [1]. |
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T33663 |
Nicotinamide Riboside Triflate
|
SRT 647 Triflate,SRT 647,Nicotinamide Riboside,Nicotinamide Ribose,SRT-647,SRT647,SRT647 Triflate,SRT-647 Triflate |
Sirtuin
|
|
Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle ... |
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T78046 |
RG7800 tetrahydrochloride
|
RO6885247 tetrahydrochloride |
DNA/RNA Synthesis
|
|
RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production. This compound holds promise as a therapeutic agent for spinal m... |
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T78197 |
5-Fluoromethylornithine dihydrochloride
|
5-FMOrn dihydrochloride |
|
|
5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific, irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT), utilized in research pertaining to gyrate atrophy of the choroid and retina [1] [2]... |
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T60042 |
NPT200-11
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|
Others
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|
NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathi... |
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T83176 |
Activated C Subunit
|
|
|
|
Activated C Subunit is utilized in synthesizing exon jumping oligomer conjugates that complement specific target sites within the human anti-muscular atrophy protein gene to promote exon 51 skipping, offering a research ... |
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T83173 |
Activated T Subunit
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|
|
|
Activated T Subunit is employed in synthesizing exon-jumping oligomer conjugates that target specific sites within the human anti-muscular atrophy protein gene to induce exon 51 skipping, a potential avenue for muscular ... |
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T83175 |
Activated DPG Subunit
|
|
|
|
Activated DPG subunit facilitates the synthesis of exon jumping oligomer conjugates targeting specific sites within the human anti-muscular atrophy protein gene to induce exon 51 skipping, a potential research avenue for... |
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T70941 |
CLR01 sodium
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|
|
|
CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro ... |
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T74683 |
IONIS-FB-LRx
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|
|
|
IONIS-FB-LRx, a targeted antisense oligonucleotide (ASO) specifically designed to inhibit complement factor B (CFB), effectively lowers circulating CFB levels. This compound has potential applications in geographic atrop... |
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T83174 |
Activated EG3 Tail
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|
|
|
Activated EG3 Tail facilitates the synthesis of exon-skipping oligomer conjugates that target specific sites within the human anti-muscular atrophy protein gene, promoting exon 51 skipping. This compound holds potential ... |
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T81693 |
NCP2 Anchor
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|
|
|
NCP2 Anchor is employed in synthesizing exon jumping oligomer conjugates that align with specific target sequences within the human anti-muscular atrophy protein gene to promote exon 52 skipping, facilitating research in... |
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T74699 |
Avacincaptad pegol
|
|
|
|
Avacincaptad pegol, a pegylated aptamer, stands out as an effective C5 complement inhibitor capable of mitigating inflammation-induced damage to the retinal pigment epithelium (RPE). This compound is under investigation ... |
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T35594 |
Cuspin-1
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|
|
|
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative dise... |
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T74881 |
FITC-labeled Tominersen
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|
|
|
FITC-labeled Tominersen is Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT p... |
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T62920 |
HDAC-IN-38
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|
|
|
HDAC-IN-38 is a potent inhibitor of HDAC. HDAC-IN-38 has similar micromolar inhibitory effects on HDAC1, 2, 3, 5, 6 and 8, and also increases histone acetylation levels (H3K14 or H4K5). HDAC-IN-38 increases cerebral bloo... |
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T38279 |
C2-8
|
C2-8 |
|
|
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola... |
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T83177 |
Activated A Subunit
|
|
|
|
Activated A Subunit is instrumental in synthesizing exon skipping oligomer conjugates, which are designed to specifically pair with chosen sequences within the human anti-muscular atrophy protein gene, thereby promoting ... |
|
T76725 |
Tilavonemab
|
|
|
|
Tilavonemab (ABBV-8E12), a humanized anti-tau antibody, targets amino acids 25-30 near the tau protein's N-terminal end. It inhibits the uptake of tau aggregates by human and mouse neurons and diminishes brain atrophy, m... |
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T80951 |
Trevogrumab
|
REGN-1033 |
|
|
Trevogrumab (REGN-1033), a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as muscle growth inhibitor), is currently under investigation for the treatment of sarcopenia, characterized by w... |
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T62381 |
Branaplam hydrochloride
|
|
|
|
Branaplam (LMI070; NVS-SM1) hydrochloride is a selective, orally active SMN2 splicing modulator that acts on SMN (EC50: 20 nM). branaplam hydrochloride inhibits hERG (IC50: 6.3 μM). In a mouse model of severe spinal musc... |
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T70174 |
Pirlindole-d4 HCl
|
|
|
|
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A ov... |
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T73453 |
MRS4719
|
|
|
|
MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec... |
