cytotoxicities | TargetMol

カタログ番号	製品名	別名	ターゲット
T6830	Epoxomicin	BU-4061T,BU-4061T,Aids010837	Apoptosis , Proteasome
	Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited...		Apoptosis , Proteasome
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
TN4864	Pungiolide A		Others
	Pungiolide A exhibits moderate cytotoxicities with IC50 values in the range of 0.90-6.84 uM.		Others
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone		Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.		Others
TN2490	1,3-Diacetylvilasinin		Others
	1,3-Diacetylvilasinin shows marginal cytotoxicities against certain human tumor cell lines. It also shows antifeeding activity towards insects.		Others
TN3009	4',5,7-Trihydroxy-6-prenylflavone		Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cance...		Others
TN2923	3'-Deoxy-4-O-methylsappanol		Tyrosinase
	3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4.		Tyrosinase
TN4630	Nemoralisin		Others
	Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines.		Others
TN1173	1-Hydroxyrutaecarpine		Others
	1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.		Others
TN4215	Hispidanin B		Others
	Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.		Others
TN2695	2,3-Dihydroamentoflavone 7,4'-dimethyl ether		Others
	2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.		Others
TN4172	Guajadial B		Topoisomerase
	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM to...		Topoisomerase
TN2493	1,4,5,6-Tetrahydroxy-7-prenylxanthone		Others
	1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI...		Others
TN5012	Shizukaol C		HIV Protease , Antifection
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>		HIV Protease , Antifection
T81170	Shishijimicin A
	Shishijimicin A, a novel antitumor agent isolated from the ascidian Didemnum proliferum, exhibits highly potent cytotoxicities and demonstrates considerable anti-tumor activity [1] [2]. This compound also serves as a cli...
T81168	Shishijimicin C
	Shishijimicin C, a novel antitumor agent isolated from the ascidian Didemnum proliferum, exhibits highly potent cytotoxicities and anti-tumor activities. This compound also serves as a click chemistry reagent, featuring ...
TN5011	Shizukaol B		ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production...
TN5153	Torilin		MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK
	Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi...