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TP1328 |
TB500
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Others
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TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. |
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T38369 |
CAY10678
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Prostaglandin Receptor
,
PD-1/PD-L1
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CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS |
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TP2308 |
TB500 acetate(885340-08-9 free base)
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Frag17-23 Acetate,TB500 Acetate |
Others
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TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col... |
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T15300 |
Fluorofenidone
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AKF-PD |
Others
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Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an... |
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T28248 |
Ono-3307 mesylate
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Ono-3307,Ono3307,Ono 3307 |
Protease
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Ono-3307 mesylate is a protease inhibitor with inhibitory effects on a variety of proteases.Ono-3307 mesylate has significant protective effects against liver injury in rats and inhibits the deposition of radiofibrillar ... |
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T2753 |
Avasimibe
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PD-148515,CI-1011 |
P450
,
Acyltransferase
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Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
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T24270 |
KS370G
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KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide |
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KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... |
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T1641 |
Strontium ranelate
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Distrontium renelate,S12911 |
Calcium Channel
,
CaSR
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Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in... |
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T67961 |
Safironil
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Others
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safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin le... |
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T124358 |
Deferoxamine
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Deferoxamine B,Desferrioxamine B |
Apoptosis
,
Antioxidant
,
HIF
,
Autophagy
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Deferoxamine（Desferrioxamine B） is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may imp... |
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T16898 |
Complement factor D-IN-1
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Others
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Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). |
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T38902 |
Cyanine 5 Tyramide
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Tyramide-Cy5 |
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Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in sit... |
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T23874 |
CESTRIN
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|
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CESTRIN is a cellulose synthase trafficking probe that acts by inhibiting cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1. |
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T71904 |
Chlormadinone (free base)
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Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in... |
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T69436 |
Endosidin7
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|
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Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis without affectting endomembrane trafficking during interphase or cytoskeletal organization. |
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T26879 |
BNC-1
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BNC 1 |
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BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and a... |
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T11359 |
Gamma-secretase modulator 2
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Others
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Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-... |
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T39181 |
Cyanine 3 Tyramide
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Cyanine 3 Tyramide,Tyramide-Cy3 |
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Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic a... |
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T26611 |
AM7499
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AM 7499,AM-7499 |
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AM7499 is a non-selective cannabinoid receptor agonist with remarkably high in vitro and in vivo potency. It is readily hydrolysed by plasma esterases and to be less prone to deposition in bodily fat than existing classi... |
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T69571 |
SEW84
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SEW84 is an inhibitor of Aha1-stimulated Hsp90(ASH) ATPase activity.SEW84 inhibits Aha1-stimulated Hsp90(ASH) activity with an IC50 value of 0.3 μM.SEW84 can be used in the study of protein deposition diseases. |
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T63691 |
Chrysamine G
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Chrysamine G is a carboxylic acid analogue of Congo red that inhibits Aβ-induced PC12 cytotoxicity.Chrysamine G can be used as a probe for amyloid deposition in Alzheimer's disease. |
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T26705 |
AZ-4217
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AZ4217,AZ 4217 |
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AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in ... |
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T33595 |
Naproxcinod
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AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582 |
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Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in... |
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TP1233 |
Amylin (8-37), rat
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Amylin (8-37) (mouse, rat) |
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Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) ... |
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T39638 |
Eprodisate
|
|
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Eprodisate is a novel compound specifically developed to disrupt the interactions between amyloidogenic proteins and glycosaminoglycans, effectively impeding the polymerization of amyloid fibrils and their deposition in ... |
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T25976 |
Ppack HCl
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Ppack dihydrochloride,Fprmecl, dihydrochloride |
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Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an... |
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T25977 |
Ppack trifluoroacetate
|
Ppack trifluoroacetate salt |
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Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been u... |
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T74402 |
FAP-PI3KI1
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|
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FAP-PI3KI1, a fibroblast-activated protein (FAP)-targeted PI3K inhibitor, selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells. It effectively inhibits collagen synthesis and reduces collage... |
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T62301 |
J-1063
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J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has poten... |
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T68302 |
KD3010 tosylate
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KD-3010 is a peroxisome proliferator-activated receptor delta agonist potentially for the treatment of diabetes and obesity. KD-3010 dramatically ameliorates liver injury induced by carbon tetrachloride (CCl(4)) injecti... |
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T78406 |
Cyanine 3 Tyramide methyl indole
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|
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Cyanine 3 Tyramide methyl indole, a derivative of the orange fluorescent dye Cyanine 3 Tyramide, serves as a reporter fluorescent substrate in the horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification... |
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T69664 |
Umibecestat HCl
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|
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Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD... |
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T74073 |
Cyanine 5 Tyramide methyl indole
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|
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Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole, a red fluorescent dye, is used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, facilitating signal amplification in immunoassay ... |
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T38048 |
Globotetraosylceramides (porcine RBC)
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|
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Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, ... |
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T64141 |
ATX inhibitor 11
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ATX inhibitor 11 is a potent inhibitor of ATX (autotaxin) (IC50: 2.7 nM). ATX inhibitor 11 alleviates the severity of fibrotic tissue and effectively reduces the deposition of α-SMA, a biomarker of fibrosis, in a mouse m... |
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T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
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|
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Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne... |
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T36357 |
Dimethyldioctadecylammonium (bromide)
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Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune ... |
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T72506 |
Antioxidant agent-8
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Antioxidant agent-8 is an orally active compound that inhibits the deposition of Aβ 1-42 by preventing fibril aggregation (IC 50 =11.15 µM) and aiding in fibril disaggregation (IC 50 =6.87 µM). Moreover, it effectively c... |
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T60438 |
PXS-6302
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|
|
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PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate... |
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T65440 |
Sodium Thiosulfate Pentahydrate
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|
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Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3... |
