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Search Results for " isoquinoline "

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カタログ番号	製品名	別名	ターゲット
T11600	IBR2	Isoquinoline	DNA/RNA Synthesis
	IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA...		DNA/RNA Synthesis
T60109	Protein kinase inhibitor H-7	5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	PKC
	Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein k...		PKC
T8921	M-31850	1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-	Others
	M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respec...		Others
T32227	Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide
	Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide is a bioactive chemical.
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T60186	(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide		Discoidin Domain Receptor (DDR)
	MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cyto...		Discoidin Domain Receptor (DDR)
T64999	5-Hydroxyisoquinoline
	5-Hydroxyisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T64999 and the CAS number is 2439-04-5.
T66594	2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
	2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66594 and the CAS number is 851784-82-2.
T67325	6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
	6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67325 and the CAS number is 204827...
T64998	1-Hydroxyisoquinoline
	1-Hydroxyisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T64998 and the CAS number is 491-30-5.
T66649	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T66649 and the CAS number is 118864-75-8.
T8860	DSRM-3716		Androgen Receptor
	Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.		Androgen Receptor
T32590	Lauformine
	Lauformine is a isoquinoline alkaloid.
T30858	CH 102	Chinoin 102,CH-102,CH102,Chinoin-102
	CH 102 is an isoquinoline derivative that inhibits platelet aggregation.
T68887	Octaverine hydrochloride
	Octaverine hydrochloride is an isoquinoline derivative that has shown inhibition of HIV (human immunodeficiency virus) reverse transcriptase.
T32546	Lamellarin H	Lamellarine H
	Lamellarin H is a benzo-isoquinoline-coumarin.
T23918	Cularine
	Cularine is an isoquinoline alkaloid from the Fumariaceae family. It displays non-specific antispasmodic activity on guinea-pig and human airways.
T33282	Memotine HCl	UK-237101,UK-2371,UK 237101,UK 2371,UK2371
	Memotine HCl has antiviral activity against respiratory tract infection and is used as a therapeutic agent for acute respiratory diseases. It is also a memo fracture in the form of hydrochloride, an isoquinoline, with an...
T35459	Glycyl H-1152 hydrochloride
	Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and prol...
T75238	YS-49 monohydrate
	YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated...

Compounds

IBR2

T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Protein kinase inhibitor H-7

T60109

Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

Target: PKC

M-31850

T8921

Synonym: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-

Target: Others

Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide

T32227

Synonym:

Target:

1,5-Isoquinolinediol

T7042

Synonym:

Target: PARP

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

T60186

Synonym:

Target: Discoidin Domain Receptor (DDR)

5-Hydroxyisoquinoline

T64999

Synonym:

Target:

2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

T66594

Synonym:

Target:

6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

T67325

Synonym:

Target:

1-Hydroxyisoquinoline

T64998

Synonym:

Target:

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Target: Androgen Receptor

Synonym: Chinoin 102,CH-102,CH102,Chinoin-102

Target:

Octaverine hydrochloride

Synonym: Lamellarine H

Synonym: UK-237101,UK-2371,UK 237101,UK 2371,UK2371

Target:

Glycyl H-1152 hydrochloride

カタログ番号	製品名	別名	ターゲット
TN1584	Dihydropalmatine	ZINC689644,2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline	Others
	Dihydropalmatine (2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline) is a natural product derived from the roots and stem barks of Berberis aristata.		Others
T8187	Tetrahydroepiberberine		Others , Influenza Virus , Antifungal
	Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities.		Others , Influenza Virus , Antifungal
T5S1895	Norisoboldine	Laurelliptine,(+)-Laurelliptine	MAPK , Adenosine Receptor
	1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisobo...		MAPK , Adenosine Receptor
T5S0055	Chelidonine	Helidonine,Khelidonin,Stylophorin	Apoptosis , Others , Influenza Virus
	1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...		Apoptosis , Others , Influenza Virus
T3933	Jatrorrhizine	Yatrorizine,neprotin	MAO , 5-HT Receptor , Antibacterial , AChE
	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...		MAO , 5-HT Receptor , Antibacterial , AChE
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T2718	Palmatine chloride		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T2874	Tetrahydroberberine	Tetrahydroberberine THB,Canadine	Dopamine Receptor , 5-HT Receptor
	Tetrahydroberberine (Canadine) is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.		Dopamine Receptor , 5-HT Receptor
T2917	Tetrahydropalmatine hydrochloride	1-Tetrahydropalmitine HCl,Gindarine hydrochloride	Others , Dopamine Receptor
	Tetrahydropalmatine hydrochloride (Gindarine hydrochloride) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo). It is a potent muscle relaxant.		Others , Dopamine Receptor
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
T5S2360	Corydaline	Corydalin,(+)-Corydaline	P450 , Virus Protease , Opioid Receptor , AChE
	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...		P450 , Virus Protease , Opioid Receptor , AChE
T32329	Juzirine
	Juzirine is a member of the class of benzylisoquinolines. Benzylisoquinolines are organic compounds containing an isoquinoline to which a benzyl group is attached. Juzirine, practically insoluble (in water), is a very we...
T83255	7(R)-7,8-Dihydrosinomenine
	7(R)-7,8-Dihydrosinomenine, an isoquinoline alkaloid extractable from Sinomenium acutum (Menispermaceae), exhibits anti-osteoclastogenic properties [1].
T83234	8-Demethoxycephatonine
	8-Demethoxycephatonine, an isoquinoline alkaloid, can be isolated from the plant Sinomenium acutum, which is part of the Menispermaceae family [1].
T83410	2,3,5,6-Tetramethoxyaporphine
	2,3,5,6-Tetramethoxyaporphine, a benzyl isoquinoline alkaloid with antitussive properties, can be extracted from Glaucium flavum Cr. (Family Papaveraceae) [1] [2].
T81159	Sibiricine
	Sibiricine (Compound 8), an isoquinoline alkaloid extracted from the medicinal plant Corydalis crispa, exhibits substantial anti-inflammatory effects by inhibiting TNF-α production in LPS-activated THP-1 cells [1].
T73640	Pancratistatin
	Pancratistatin, an isoquinoline alkaloid extracted from Hymenocallis littoralis, induces apoptosis in human melanoma cells and is utilized in researching neuroblastoma, leukemia, and breast cancer [1].
T75433	Norisoboldine hydrochloride
	Norisoboldine hydrochloride, an orally active aryl hydrocarbon receptor (AhR) agonist and a prominent isoquinoline alkaloid found in Radix Linderae, is utilized for research purposes in the study of Rheumatoid Arthritis ...

天然物製品

Dihydropalmatine

TN1584

Synonym: ZINC689644,2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline

Target: Others

Tetrahydroepiberberine

T8187

Synonym:

Target: Others, Influenza Virus, Antifungal

Norisoboldine

T5S1895

Synonym: Laurelliptine,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Chelidonine

T5S0055

Synonym: Helidonine,Khelidonin,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Jatrorrhizine

T3933

Synonym: Yatrorizine,neprotin

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine chloride

T4912

Synonym: Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Palmatine chloride

T2718

Synonym:

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Liensinine

T5S1099

Synonym:

Target: Apoptosis, Mitophagy, Others, Autophagy

Tetrahydroberberine

T2874

Synonym: Tetrahydroberberine THB,Canadine

Target: Dopamine Receptor, 5-HT Receptor

Tetrahydropalmatine hydrochloride

T2917

Synonym: 1-Tetrahydropalmitine HCl,Gindarine hydrochloride

Target: Others, Dopamine Receptor

Liensinine diperchlorate

T4S1102

Synonym: Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Corydaline

T5S2360

Synonym: Corydalin,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

7(R)-7,8-Dihydrosinomenine

T83255

Synonym:

Target:

8-Demethoxycephatonine

T83234

Synonym:

Target:

2,3,5,6-Tetramethoxyaporphine

Norisoboldine hydrochloride

T75433

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03128	TSPO Protein, Pig, Recombinant (His & Myc & SUMO)	Sus scrofa (Pig)	E. coli
	Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynt...

TSPO Protein, Pig, Recombinant (His & Myc & SUMO)

TMPH-03128

Species: Sus scrofa (Pig)

Expression System: E. coli

カタログ番号	製品名
L6110	Alkaloid Natural Product Library		464 compounds
	A unique collection of 464 natural alkaloids can be used for high throughput and high content screening；

ライブラリー

Alkaloid Natural Product Library

L6110

Compounds: 464