|
T8976 |
PD-089828
|
|
EGFR
,
FGFR
,
PDGFR
,
Src
|
|
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ... |
|
T27606 |
Indantadol HCl
|
CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol |
MAO
,
NMDAR
|
|
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor. |
|
T12444 |
Phentolamine Analogue 1
|
|
Adrenergic Receptor
|
|
Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic. |
|
T6387 |
Ampiroxicam
|
CP 65703,Flucam |
COX
|
|
Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
|
T8738 |
LUN42518 HCl 47142-51-8(free base)
|
|
Adrenergic Receptor
|
|
LUN42518 HCl is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist. |
|
T10355 |
Apyramide
|
|
COX
|
|
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2. |
|
T64373 |
CDK1-IN-2
|
cdk1 inhibitor 2 |
CDK
|
|
CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases. |
|
T3951 |
NSC632839
|
F6,Ubiquitin Isopeptidase Inhibitor II |
DUB
|
|
NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM). |
|
T21389 |
Enprofylline
|
Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum |
Others
|
|
Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick... |
|
T1889 |
CP-640186
|
CP 640186 |
Acetyl-CoA Carboxylase
|
|
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. |
|
T1282 |
Carteolol hydrochloride
|
Arteoptic,Abbott-43326,OPC-1085 hydrochloride,Carteolol HCl,Mikelan |
Adrenergic Receptor
|
|
Carteolol hydrochloride (Abbott-43326) is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-s... |
|
T3622 |
CP-640186 hydrochloride
|
CP 640186 HCl |
Acetyl-CoA Carboxylase
|
|
CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit... |
|
T2137 |
Ibudilast
|
AV-411,KC-404,MN-166 |
PDE
|
|
Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan. |
|
T20898 |
(R)-Propranolol hydrochloride
|
Dexpropranolol hydrochloride,(R)-(+)-Propranolol |
Adrenergic Receptor
|
|
(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antag... |
|
T1275 |
Phentolamine mesylate
|
Phentolamine methanesulfonate,Phentolamine mesilate |
Adrenergic Receptor
|
|
Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS... |
|
T4612 |
NS309
|
|
EGFR
,
Potassium Channel
,
HER
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... |
|
TP1910L1 |
CALP1 acetate
|
CALP1 acetate(145224-99-3 free base) |
CaMK
|
|
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo... |
|
T38240 |
2,6-Dichlorodiphenylamine
|
|
Antibacterial
|
|
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1... |
|
T28024 |
Metfendrazine
|
NSC 169501,A-17767,A 17767,methphendrazine,A17767 |
|
|
Metfendrazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI). |
|
T32699 |
Levobunolol
|
Levobunololum,Liquifilm,AK-Beta,Betegan |
|
|
Levobunolol is a nonselective beta-blocker. It is used topically to treat glaucoma. |
|
T25144 |
Benmoxin
|
Neuralex,Nerusil |
|
|
Benmoxin is a monoamine oxidase inhibitor (MAOI) that is irreversible and nonselective. |
|
T25205 |
Caroxazone
|
|
|
|
Caroxazone is an antidepressant drug, monoamine oxidase inhibitor (MAOI) that is irreversible and nonselective meanwhile. |
|
T68488 |
Indatraline
|
|
|
|
Indatraline is a nonselective monoamine transporter inhibitor. |
|
T12402L |
Penbutolol
|
HOE 893,l-Penbutolol,Levopenbutol,HOE 893D,Betapressin |
|
|
Penbutolol is a nonselective beta-blocker utilized as an antihypertensive and an antianginal. |
|
T4560L1 |
Alprenolol hydrochloride, (S)-
|
L-Alloprenalol hydrochloride |
|
|
Alprenolol hydrochloride, (S)- is a nonselective β-blocker. It is also a serotonin 5HT1A receptor antagonist. |
|
T28977 |
Tilisolol HCl
|
Tilisolol, trade name Selecal,N 696,N-696,N696 |
|
|
Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs. |
|
T15386 |
Glisoxepide
|
|
Others
|
|
Glisoxepide is a sulphonamide derivative and is an orally available nonselective K(ATP) channel blocker. It has antihyperglycemic activity and cardiovascular regulation effect. |
|
T24631 |
Pheniprazine hydrochloride
|
Pheniprazine HCl,NSC 17766,CCRIS 1417,NSC-17766,NSC17766 |
|
|
Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor of the hydrazine chemical class. It was also used in the treatment of angina pectoris and schizophrenia. |
|
T12701 |
(rel)-Tranylcypromine D5 hydrochloride
|
2-Phenylcyclopropylamine D5 hydrochloride |
Histone Demethylase
|
|
(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible, nonselective inhibitor of monoamine oxidase (MAO) used in the tre... |
|
T10371 |
Arotinolol
|
|
5-HT Receptor
|
|
Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is... |
|
T37893 |
3-MPPI
|
|
|
|
3-MPPI was a high-affinity nonselective α1-antagonist. |
|
T69267 |
Naproxen glucuronide
|
|
|
|
Naproxen glucuronide is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen) that relieves pain, fever, swelling, and stiffness. It is a nonselective COX inhibitor. |
|
T12550 |
Propranolol-d7 hydrochloride
|
Propranolol D7 hydrochloride |
Others
|
|
Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective antagonist of β-adrenergic receptor (βAR). |
|
T11754 |
Ketorolac-d5
|
Ketorolac D5 |
PPAR
|
|
Ketorolac D5, a deuterium-labeled version of Ketorolac, is a non-steroidal anti-inflammatory agent that functions as a nonselective COX inhibitor. It exhibits IC50 values of 20 nM for COX-1 and 120 nM for COX-2. |
|
T40757 |
1-Stearoyl-2-arachidonoyl-sn-glycerol
|
|
|
|
1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) encompassing polyunsaturated fatty acids, possesses the ability to activate PKC. Moreover, this compound has the potential to enhance nonselective cation chan... |
|
T11655 |
Indomethacin-D4
|
Indometacin-D4 |
CDK
|
|
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. |
|
T69031 |
Cirazoline (free base)
|
|
|
|
Cirazoline (free base) is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α₂ adrenergic receptor. It is believed that th... |
|
T13069 |
Talabostat isomer mesylate
|
|
Others
|
|
Talabostat isomer mesylate is an isomer of talabostat mesylate. Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available inhibitor of dipeptidyl peptidase IV (DPP-IV)(Ki of 0.18 nM). |
|
T69019 |
Mecamylamine
|
|
|
|
Mecamylamine, an orally active, nonselective, noncompetitive antagonist of nAChR (nicotinic acetylcholine receptors), exhibits ganglionic blockade capabilities and can cross the blood-brain barrier. Its applications span... |
|
T76262 |
Cagrilintide
|
|
|
|
Cagrilintide, an investigational novel long-acting acylated amylin analogue, functions as an agonist for nonselective amylin receptors (AMYR) and the calcitonin G protein-coupled receptor (CTR). It significantly reduces ... |
|
T60704 |
Loxoprofen sodium (dihydrate)
|
|
|
|
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent that has analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate exhibits antitumor activity which also can reduce atherosc... |
|
T37861 |
Talabostat
|
|
|
|
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ... |
|
T21750 |
A 784168
|
|
|
|
A-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, an... |
|
T60496 |
Ketorolac hemicalcium
|
|
|
|
Ketorolac (RS37619) hemicalcium is a nonselective COX inhibitor with IC50s of 20 nM and 120 nM for COX-1 and COX-2, respectively. Ketorolac hemicalcium is a non-steroidal anti-inflammatory drug (NSAID) that is used as 0.... |
|
T75791 |
CALP1 TFA
|
|
|
|
CALP1 TFA, a calmodulin (CaM) agonist with a dissociation constant (Kd) of 88 µM, selectively binds to the CaM EF-hand/Ca2+-binding site, inhibiting calcium channel opening. This action blocks calcium influx and apoptosi... |
