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Search Results for " p35 "

ターゲット

阻害剤

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T7167	Purvalanol B	NG 95	CDK , Parasite
	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)		CDK , Parasite
T2095	Seliciclib	Roscovitine,R-roscovitine,CYC202	CDK
	Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).		CDK
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T22260	Aminopurvalanol A		CDK
	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...		CDK
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T37207L	Cdk5 Substrate acetate		CDK
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...		CDK
T21720	GP-82996	Cdk4/6 Inhibitor IV,CINK4	CDK
	GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U...		CDK
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T2059	Purvalanol A	NG-60	Apoptosis , CDK , Autophagy
	Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.		Apoptosis , CDK , Autophagy
T22590	AT7519 TFA	AT7519 trifluoroacetate	Others
	AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).		Others
T21377	Aloisine A
	Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS...
T11653	Indirubin-5-sulfonate		Others
	Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli...		Others
T37207	Cdk5 Substrate	Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a ...
T73196	RGB-286638
	RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM...
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T1917	GSK 3 Inhibitor IX	BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis , GSK-3 , Tyrosine Kinases , CDK
	GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.		Apoptosis , GSK-3 , Tyrosine Kinases , CDK
T1778	AT7519 Hydrochloride	AT7519 HCl,AT 7519 hydrochloride salt	Apoptosis , GSK-3 , CDK
	AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.		Apoptosis , GSK-3 , CDK
T10898	Samuraciclib hydrochloride	ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis , CDK
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...		Apoptosis , CDK
T14779	BRD7389		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
T11345L	Lerociclib dihydrochloride	G1T38 dihydrochloride	CDK
	Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.		CDK
T5533	MC180295	(rel)-MC180295	CDK
	MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.		CDK
TQ0068	NVP-LCQ195	AT9311,LCQ-195	CDK
	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).		CDK
T10464	Atuveciclib	BAY-1143572	CDK
	Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].		CDK
T11345	Lerociclib	G1T38	CDK
	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.		CDK

Compounds

ALSTERPAULLONE

T7426

Synonym:

Target: Apoptosis, GSK-3, CDK

Purvalanol B

T7167

Synonym: NG 95

Target: CDK, Parasite

Seliciclib

T2095

Synonym: Roscovitine,R-roscovitine,CYC202

Target: GSK-3, MEK, JAK, CDK

Cdk5 Substrate acetate

Synonym: Cdk4/6 Inhibitor IV,CINK4

Target: CDK

Indirubin-3'-monoxime

T5200

Synonym: Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

Purvalanol A

T2059

Synonym: NG-60

Target: Apoptosis, CDK, Autophagy

AT7519 TFA

T22590

Synonym: AT7519 trifluoroacetate

Indirubin-5-sulfonate

Synonym: Cdk5 Substrate

Synonym: 9-Bromopaullone,NSC-664704

Target: GSK-3, CDK

GSK 3 Inhibitor IX

T1917

Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime

Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK

AT7519 Hydrochloride

T1778

Synonym: AT7519 HCl,AT 7519 hydrochloride salt

Target: Apoptosis, GSK-3, CDK

Samuraciclib hydrochloride

T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

BRD7389

T14779

Synonym:

Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK

Lerociclib dihydrochloride

T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

MC180295

T5533

Synonym: (rel)-MC180295

Target: CDK

NVP-LCQ195

TQ0068

Synonym: AT9311,LCQ-195

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02350	IL-12 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.3 kDa. Accession number: P43431&P43432
TMPY-04793	IL-35 Protein, Human, Recombinant (Flag & His)	Human	HEK293
	IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPY-04863	IL-12 Protein, Human, Recombinant	Human	HEK293
	IL-12 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 57.2 kDa. Accession number: P29459-1&NP_002178.2
TMPY-01409	IL-12A Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-00838	IL-12A Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...
TMPY-06105	IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His)	Human	HEK293
	IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPK-00768	ANXA1 Protein, Human, Recombinant (His)	Human	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPY-02349	IL-12 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 111.5 kDa. Accession number: P43431&P43432
TMPY-02351	IL-12 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	IL-12 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 with His and hFc tag. The predicted molecular weight is 85.9 kDa. Accession number: P43431&P43432
TMPY-03879	IL-35 Protein, Human, Recombinant	Human	HEK293
	IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, ...
TMPJ-00766	ANXA1 Protein, Human, Recombinant	Human	E. coli
	Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-infla...
TMPK-00799	ANXA1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-01291	ANXA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPY-02109	IL-12 Protein, Human, Recombinant (His)	Human	HEK293
	IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459-1&NP_002178.2
TMPY-05458	IL-12 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 60.13 kDa. Accession number: P29459.2&NP_002178.2
TMPY-00144	Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His)	EBV	Baculovirus-Insect Cells
	Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 53.7 kDa. Accession number: A0A0B6VN60
TMPY-06322	Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated	EBV	HEK293
	Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 55.51 kDa. Accession number: YP_401667.1
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)	ZEBOV	HEK293
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-02383	Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)	MARV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPY-03142	IL-27 Protein, Human, Recombinant (His)	Human	CHO
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPH-01398	GSTP1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01399	GSTP1 Protein, Human, Recombinant (His)	Human	Yeast
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-02683	GSTP1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPY-04556	CDK5 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which...
TMPY-04268	NUDC Protein, Human, Recombinant (His)	Human	HEK293
	NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic...
TMPJ-00499	GSTP1 Protein, Human, Recombinant	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...
TMPY-04105	IL-12A Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 ...