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Search Results for " p35 "

ターゲット

25

阻害剤

26

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T7426 ALSTERPAULLONE Apoptosis , GSK-3 , CDK
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
T7167 Purvalanol B NG 95 CDK , Parasite
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)
T2095 Seliciclib Roscovitine,R-roscovitine,CYC202 CDK
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).
T21588 Olomoucine ERK , CDK
Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...
T2378 RGB-286638 free base GSK-3 , MEK , JAK , CDK
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...
T22260 Aminopurvalanol A CDK
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...
T21720 GP-82996 Cdk4/6 Inhibitor IV,CINK4 CDK
GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U...
T5200 Indirubin-3'-monoxime Indirubin-3'-oxime GSK-3 , Lipoxygenase , CDK
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
T37207L Cdk5 Substrate acetate CDK
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...
T2059 Purvalanol A NG-60 Apoptosis , CDK , Autophagy
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.
T22590 AT7519 TFA AT7519 trifluoroacetate Others
AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T11653 Indirubin-5-sulfonate Others
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli...
T21377 Aloisine A
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS...
T37207 Cdk5 Substrate Cdk5 Substrate
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a ...
T73196 RGB-286638
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM...
T2247 KenPaullone 9-Bromopaullone,NSC-664704 GSK-3 , CDK
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...
T1917 GSK 3 Inhibitor IX BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime Apoptosis , GSK-3 , Tyrosine Kinases , CDK
GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.
T1778 AT7519 Hydrochloride AT7519 HCl,AT 7519 hydrochloride salt Apoptosis , GSK-3 , CDK
AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T14779 BRD7389 SGK , FLT , Pim , CDK , S6 Kinase , DAPK
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T10898 Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride Apoptosis , CDK
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...
T5533 MC180295 (rel)-MC180295 CDK
MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.
T11345L Lerociclib dihydrochloride G1T38 dihydrochloride CDK
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
TQ0068 NVP-LCQ195 AT9311,LCQ-195 CDK
NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
T10464 Atuveciclib BAY-1143572 CDK
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
T11345 Lerociclib G1T38 CDK
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.

Compounds

ALSTERPAULLONE
T7426
Synonym:
Target: Apoptosis, GSK-3, CDK
Purvalanol B
T7167
Synonym: NG 95
Target: CDK, Parasite
Seliciclib
T2095
Synonym: Roscovitine,R-roscovitine,CYC202
Target: CDK
Olomoucine
T21588
Synonym:
Target: ERK, CDK
RGB-286638 free base
T2378
Synonym:
Target: GSK-3, MEK, JAK, CDK
Aminopurvalanol A
T22260
Synonym:
Target: CDK
GP-82996
T21720
Synonym: Cdk4/6 Inhibitor IV,CINK4
Target: CDK
Indirubin-3'-monoxime
T5200
Synonym: Indirubin-3'-oxime
Target: GSK-3, Lipoxygenase, CDK
Cdk5 Substrate acetate
T37207L
Synonym:
Target: CDK
Purvalanol A
T2059
Synonym: NG-60
Target: Apoptosis, CDK, Autophagy
AT7519 TFA
T22590
Synonym: AT7519 trifluoroacetate
Target: Others
Indirubin-5-sulfonate
T11653
Synonym:
Target: Others
Aloisine A
T21377
Synonym:
Target:
Cdk5 Substrate
T37207
Synonym: Cdk5 Substrate
Target:
RGB-286638
T73196
Synonym:
Target:
KenPaullone
T2247
Synonym: 9-Bromopaullone,NSC-664704
Target: GSK-3, CDK
GSK 3 Inhibitor IX
T1917
Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime
Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK
AT7519 Hydrochloride
T1778
Synonym: AT7519 HCl,AT 7519 hydrochloride salt
Target: Apoptosis, GSK-3, CDK
BRD7389
T14779
Synonym:
Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK
Samuraciclib hydrochloride
T10898
Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride
Target: Apoptosis, CDK
MC180295
T5533
Synonym: (rel)-MC180295
Target: CDK
Lerociclib dihydrochloride
T11345L
Synonym: G1T38 dihydrochloride
Target: CDK
NVP-LCQ195
TQ0068
Synonym: AT9311,LCQ-195
Target: CDK
Atuveciclib
T10464
Synonym: BAY-1143572
Target: CDK
Lerociclib
T11345
Synonym: G1T38
Target: CDK

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-04793 IL-35 Protein, Human, Recombinant (Flag & His) Human HEK293 Cells
IL-35 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 48.3 kDa and the accession number is P29459-1.
TMPY-02350 IL-12 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
IL-12 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.3 kDa and the accession number is P43431&P43432.
TMPY-04863 IL-12 Protein, Human, Recombinant Human HEK293 Cells
IL-12 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.2 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-01409 IL-12A Protein, Human, Recombinant (His) Human HEK293 Cells
IL-12A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P29459.
TMPY-00838 IL-12A Protein, Human, Recombinant (hFc) Human HEK293 Cells
IL-12A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is P29459.
TMPY-06105 IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His) Human HEK293 Cells
IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His) is expressed in HEK293 mammalian cells with Fc-Flag, Fc-His tag. The predicted molecular weight is 102.1 kDa and the accession number is Q14213.
TMPY-03879 IL-35 Protein, Human, Recombinant Human HEK293 Cells
IL-35 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 102 kDa and the accession number is P29459-1.
TMPY-02349 IL-12 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.5 kDa and the accession number is P43431&P43432.
TMPY-02351 IL-12 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293 Cells
IL-12 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 85.9 kDa and the accession number is P43431&P43432.
TMPK-00768 ANXA1 Protein, Human, Recombinant (His) Human E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPJ-00766 ANXA1 Protein, Human, Recombinant Human E. coli
Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-infla...
TMPK-00799 ANXA1 Protein, Mouse, Recombinant (His) Mouse E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-01291 ANXA1 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPY-02109 IL-12 Protein, Human, Recombinant (His) Human HEK293 Cells
IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-05458 IL-12 Protein, Human, Recombinant (His), Biotinylated Human HEK293 Cells
IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459.2&NP_002178.2.
TMPY-00144 Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His) EBV Baculovirus Insect Cells
Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is A0A0B6VN60.
TMPY-06322 Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated EBV HEK293 Cells
Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 55.51 kDa and the accession number is YP_4016...
TMPH-03733 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc) ZEBOV HEK293 Cells
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-02383 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His) MARV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPH-03732 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc) ZEBOV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-02683 GSTP1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01399 GSTP1 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01398 GSTP1 Protein, Human, Recombinant (E. coli, His) Human E. coli
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPY-04556 CDK5 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which...
TMPJ-00499 GSTP1 Protein, Human, Recombinant Human E. coli
Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...
TMPY-04268 NUDC Protein, Human, Recombinant (His) Human HEK293 Cells
NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic...
IL-35 Protein, Human, Recombinant (Flag & His)
TMPY-04793
Species: Human
Expression System: HEK293 Cells
IL-12 Protein, Mouse, Recombinant (His)
TMPY-02350
Species: Mouse
Expression System: HEK293 Cells
IL-12 Protein, Human, Recombinant
TMPY-04863
Species: Human
Expression System: HEK293 Cells
IL-12A Protein, Human, Recombinant (His)
TMPY-01409
Species: Human
Expression System: HEK293 Cells
IL-12A Protein, Human, Recombinant (hFc)
TMPY-00838
Species: Human
Expression System: HEK293 Cells
IL-35 Protein, Human, Recombinant (Fc-Flag & Fc-His)
TMPY-06105
Species: Human
Expression System: HEK293 Cells
IL-35 Protein, Human, Recombinant
TMPY-03879
Species: Human
Expression System: HEK293 Cells
IL-12 Protein, Mouse, Recombinant (hFc)
TMPY-02349
Species: Mouse
Expression System: HEK293 Cells
IL-12 Protein, Mouse, Recombinant (His & hFc)
TMPY-02351
Species: Mouse
Expression System: HEK293 Cells
ANXA1 Protein, Human, Recombinant (His)
TMPK-00768
Species: Human
Expression System: E. coli
ANXA1 Protein, Human, Recombinant
TMPJ-00766
Species: Human
Expression System: E. coli
ANXA1 Protein, Mouse, Recombinant (His)
TMPK-00799
Species: Mouse
Expression System: E. coli
ANXA1 Protein, Cynomolgus, Recombinant (His)
TMPK-01291
Species: Cynomolgus
Expression System: E. coli
IL-12 Protein, Human, Recombinant (His)
TMPY-02109
Species: Human
Expression System: HEK293 Cells
IL-12 Protein, Human, Recombinant (His), Biotinylated
TMPY-05458
Species: Human
Expression System: HEK293 Cells
Epstein-Barr virus (Herpesvirus 4) EBV Glycoprotein gp350/EBV GP350 Protein (His)
TMPY-00144
Species: EBV
Expression System: Baculovirus Insect Cells
Epstein-Barr virus (B95-8) Glycoprotein gp350 Protein (His & Avi), Biotinylated
TMPY-06322
Species: EBV
Expression System: HEK293 Cells
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
TMPH-03733
Species: ZEBOV
Expression System: HEK293 Cells
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)
TMPH-02383
Species: MARV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
TMPH-03732
Species: ZEBOV
Expression System: E. coli
GSTP1 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02683
Species: Mouse
Expression System: E. coli
GSTP1 Protein, Human, Recombinant (His)
TMPH-01399
Species: Human
Expression System: P. pastoris (Yeast)
GSTP1 Protein, Human, Recombinant (E. coli, His)
TMPH-01398
Species: Human
Expression System: E. coli
CDK5 Protein, Human, Recombinant (GST)
TMPY-04556
Species: Human
Expression System: Baculovirus Insect Cells
GSTP1 Protein, Human, Recombinant
TMPJ-00499
Species: Human
Expression System: E. coli
NUDC Protein, Human, Recombinant (His)
TMPY-04268
Species: Human
Expression System: HEK293 Cells