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T9984 |
Antimalarial agent 13
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N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine |
Parasite
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Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent. |
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T36102 |
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone dea... |
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T50083 |
12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide
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Others
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12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide available as a molecular structural unit, it is used in the synthesis of various compounds. |
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T17204 |
UNC0321
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Histone Methyltransferase
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UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. |
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T4288 |
HVEGF-IN-1
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VEGFR
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hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity. |
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T17203 |
UNC0224
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Histone Methyltransferase
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UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. |
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T66391 |
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is a useful organic compound for research related to life sciences. The catalog number is T66391 and the CAS number is 314771-76-1. |
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T14336 |
Allitinib
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AST-1306,ALS 1306 |
EGFR
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Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1] |
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T4296 |
MTX-211
|
MTX 211 |
EGFR
,
PI3K
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MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases. |
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T0197 |
Terazosin hydrochloride
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Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor
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Terazosin hydrochloride (Hytrin) , a selective alpha1-antagonist, can treat the benign prostatic hyperplasia (BPH). It also can lower blood pressure, so it is a drug of choice for patients with prostate enlargement and h... |
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T6331 |
Allitinib tosylate
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AST-1306 TsOH,AST-6,Allitinib,AST-1306,AST-1306 (TsOH) |
EGFR
,
FLT
|
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Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively. |
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T6701 |
Terazosin hydrochloride dihydrate
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Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate |
Adrenergic Receptor
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Terazosin hydrochloride dihydrate (Heitrin dihydrate) is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH). |
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T72072 |
2-benzylsulfanyl-6-methoxy-4-methylquinazoline
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ROS
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2-benzylsulfanyl-6-methoxy-4-methylquinazoline can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity, such as lysosomal storage disease, muscular dystrophy, oxidative stress or rea... |
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T8565 |
N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride
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TRP/TRPV Channel
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N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4. |
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T66340 |
4,6-Dichloro-7-methoxyquinazoline
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4,6-Dichloro-7-methoxyquinazoline is a useful organic compound for research related to life sciences. The catalog number is T66340 and the CAS number is 205584-69-6. |
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T65621 |
2-(Chloromethyl)-4-methylquinazoline
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2-(Chloromethyl)-4-methylquinazoline is a useful organic compound for research related to life sciences. The catalog number is T65621 and the CAS number is 109113-72-6. |
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T65018 |
2-Chloro-4-amino-6,7-dimethoxyquinazoline
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2-Chloro-4-amino-6,7-dimethoxyquinazoline is a useful organic compound for research related to life sciences. The catalog number is T65018 and the CAS number is 23680-84-4. |
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T125912 |
Fumiquinazoline A
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Fumiquinazoline A is a useful organic compound for research related to life sciences. The catalog number is T125912 and the CAS number is 140715-85-1. |
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T126280 |
Carnequinazoline A
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|
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Carnequinazoline A is a useful organic compound for research related to life sciences. The catalog number is T126280 and the CAS number is 1175962-86-3. |
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T66020 |
4-Chloroquinazoline-6,7-diol
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4-Chloroquinazoline-6,7-diol is a useful organic compound for research related to life sciences. The catalog number is T66020 and the CAS number is 1145671-36-8. |
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T64861 |
2,4-Dichloro-6,7-dimethoxyquinazoline
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2,4-Dichloro-6,7-dimethoxyquinazoline is a useful organic compound for research related to life sciences. The catalog number is T64861 and the CAS number is 27631-29-4. |
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T6153 |
Icotinib
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BPI-2009,BPI-2009H,Conmana |
EGFR
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Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. |
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T34609 |
Selurampanel
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BGG-492,BGG 492,BGG492 |
iGluR
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Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
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T0101 |
Doxazosin mesylate
|
UK 33274 mesylate |
Mitophagy
,
Adrenergic Receptor
,
Autophagy
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Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors. |
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T2307 |
Icotinib Hydrochloride
|
BPI-2009H |
EGFR
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Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type ... |
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T1066 |
Ketanserin
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R41468,Ketanserin tartrate,Ketanserinum |
Potassium Channel
,
5-HT Receptor
,
Autophagy
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Ketanserin (Ketanserinum) is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration,... |
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T2501 |
Canertinib dihydrochloride
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CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib |
EGFR
|
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Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. |
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T8758 |
Poziotinib hydrochloride
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HM 781-36B hydrochloride,NOV120101 hydrochloride |
EGFR
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Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavaila... |
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T1773 |
Afatinib Dimaleate
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BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate |
EGFR
,
HER
,
Autophagy
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Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act... |
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T2627 |
Nolatrexed dihydrochloride
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Thymitaq,AG 337 |
DNA/RNA Synthesis
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Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidyla... |
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T77615 |
ND-011992
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ND011992 |
Mitochondrial Metabolism
,
Antibacterial
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ND-011992 is a reversible and selective quinazoline inhibitor targeting quinone reductases and quinol oxidases.ND-011992 inhibits E. coli BL21*Δcyo respiratory complex I. ND-011992 inhibits bo3 oxidase, bd-I oxidases and... |
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T19938 |
Fenazaquin
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XDE-436,EL-436,XDE436,EL436,XDE 436,EL 436 |
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Fenazaquin is quinazoline derivatives and alkyl aryl ethers |
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T28326 |
PD 130883
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PD-130883,PD130883 |
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PD 130883 is a potent lipophilic quinazoline antifolate. |
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T14879 |
CB 300919
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Others
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CB 300919 is a quinazoline-based antitumor agent with high activity in the CH1 human ovarian tumor xenograft and has continuous exposure (96 h) growth inhibition (IC50: 2 nM). |
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T82330 |
GCase modulator-1
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Glucosidase
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GCase Modulator-1 (Compound 9g), a quinazoline derivative, functions as a glucosidase modulator with an AC50 value of 2.23 µM [1]. |
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T71623 |
ICI-M247496
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ICI-M247496 is a non-polyglutamated analog of CB3717 and quinazoline-based inhibitor of thymidylate synthase. |
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T24255 |
KB 5666
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KB-5666,KB5666 |
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KB 5666, a quinazoline derivative, is a lipid peroxidation inhibitor. It protects the brain from both cellular and functional consequences of ischemia. |
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T62476 |
Trimazosin
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Trimazosin is an orally active quinazoline derivative, structurally related to prazosin. trimazosin has hypotensive activity by selectively blocking alpha1-adrenoceptors. |
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T19297 |
Doxazosin D8
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UK 33274 D8 |
Others
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Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor. |
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T37817 |
Terazosin dimer impurity dihydrochloride
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Terazosin dimer impurity dihydrochloride, a dimeric form of Terazosin, is a chemical impurity found in Terazosin. Terazosin itself is a derivative of quinazoline and acts as a competitive and orally active α1-adrenocepto... |
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T74663 |
KRAS G12D inhibitor 17
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KRAS G12D Inhibitor 17 (example 8), a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, acts as a proteolysis targeting chimera (PROTAC) [1], specifically inducing degradation of the G12D-mutation KRAS protein. |
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T61729 |
Terazosin
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Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeut... |
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T62509 |
Antitumor agent-74
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Antitumor agent-74 is a quinazoline derivative and an antitumour agent. antitumor agent-74 in combination with the regional tautomer Antitumor agent-75 (compound 14 da) (mriBIQ 13da/14da) exhibits enhanced tumour inhibit... |
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T79739 |
CYP51/PD-L1-IN-2
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CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal ... |
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T35534 |
7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine
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7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors.
1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery a... |
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T79738 |
CYP51/PD-L1-IN-1
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CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, marked... |
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T79740 |
CYP51/PD-L1-IN-3
|
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CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis within the ... |
