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T0283 |
Trimethadione
|
3,5,5,-Trimethyloxazolidine-2,4-dione |
Calcium Channel
|
|
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity. |
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T8594 |
Pheneturide
|
2-PHENYLBUTYRYLUREA,S-46,Benuride |
Others
|
|
Pheneturide (Benuride) is the ureide class, used to treat epilepsy, and is an anticonvulsant. |
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T23782 |
Benzolamide
|
CL-11366,W 1803,CL 11366,CL11366,W-1803 |
Carbonic Anhydrase
|
|
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons. |
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T7806 |
Licarbazepine
|
10,11-hydroxy-10,11 Dihydrocarbamezer |
Others
|
|
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. |
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T3285L |
Eslicarbazepine
|
Pazzul,EC 810-248-9,BIA 2-194,Stedesa,Erelib |
Beta-Secretase
,
Sodium Channel
|
|
Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures. |
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T15302 |
Fluzinamide
|
AHR-8559 |
Others
|
|
Fluzinamide (AHR-8559) has anticonvulsant effects on ignited amygdala seizures. |
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T27845 |
Losigamone
|
ADD-137022,AO33,AO 33,ADD 137022,AO-33,ADD137022;Losigamone |
GABA Receptor
|
|
Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures. |
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T22171 |
WWL123
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|
MAGL
|
|
WWL123 is a potent and selective ABHD6 inhibitor (IC50=430 nM). WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole... |
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T1249 |
Beclamide
|
N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon |
Others
|
|
Beclamide (Chlorakon) (N-benzyl-B-chloropropionamide) is a drug that possesses anticonvulsant activity. It is no longer used. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its a... |
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T68054 |
Denzimol
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|
Others
|
|
Denzimol is a novel anticonvulsant compound.Denzimol is selective for tonic seizures. |
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T40864 |
Magnesium sulfate
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|
Others
|
|
Magnesium sulfate is the preferred anticonvulsant for preventing and controlling eclamptic seizures. Additionally, it is extensively utilized as a tocolytic agent. |
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T12156 |
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
|
|
Others
|
|
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures. |
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T23717 |
Ameltolide
|
|
Others
|
|
Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models. |
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T3285 |
Eslicarbazepine Acetate
|
Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa |
Beta-Secretase
,
Sodium Channel
|
|
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve... |
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T29201 |
Z944
|
Z 944,Z-944 |
Calcium Channel
|
|
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. |
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T6953 |
Prilocaine
|
Citanest,Propitocaine,NSC 40027 |
ATPase
,
Sodium Channel
|
|
Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures. |
|
T68058 |
Dulozafone
|
F1933 |
Others
|
|
Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures. |
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T73556 |
CZL55
|
|
Caspase
|
|
CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS). |
|
T23508 |
VU 0255035
|
|
AChR
|
|
muscarinic M1 antagonist |
|
T21526 |
α-Guanidinoglutaric Acid
|
|
Others
|
|
α-Guanidinoglutaric Acid is found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric Acid-induced seizures are associated with abnormal serotonergic function and that they ar... |
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T14384 |
AZD8797
|
KAN-0440567,KAND567 |
CXCR
|
|
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi... |
|
T0675 |
Topiramate
|
RWJ 17021,McN 4853 |
Potassium Channel
,
Calcium Channel
,
GABA Receptor
,
Sodium Channel
,
GluR
,
Carbonic Anhydrase
,
iGluR
|
|
Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and largely when used in combination ... |
|
T11800 |
L-803087
|
|
Somatostatin
|
|
|
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T0192 |
Levetiracetam
|
UCB L059,SIB-S1 |
DNA Methyltransferase
,
Others
,
Calcium Channel
|
|
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... |
|
T37149 |
Carbamazepine 10,11-epoxide
|
|
Others
|
|
Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e... |
|
T0267 |
Zonisamide
|
AD 810,CI 912 |
Calcium Channel
,
Sodium Channel
,
Carbonic Anhydrase
|
|
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... |
|
T25307 |
Denzimol hydrochloride
|
REC 15-1533 |
|
|
Denzimol hydrochloride is a new anticonvulsant drug that inhibits electrically and chemically induced tonic seizures but does not stop clonic seizures. It behaves similarly to phenytoin and carbamazepine, but differently... |
|
T23037 |
N-Acetylglycyl-D-glutamic acid
|
|
Others
|
|
Excitatory peptide that induces seizures |
|
T71206 |
Tiagabine-d6 hydrochloride
|
|
|
|
Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduc... |
|
T28766 |
SGE-516
|
SGE516 |
|
|
SGE516 is a neuroactive steroid and a positive allosteric modulator of both gamma- and delta-containing GABAA receptors. SGE516 reduces neuronal firing rates and epileptiform activity in vitro. SGE-516 protects against a... |
|
T82294 |
GLUT1-IN-3
|
|
|
|
GLUT1-IN-3 (Compd 4b), a compound under investigation for type 1 glucose transporter deficiency syndrome, effectively inhibits seizures [1]. |
|
T37557 |
(-)-(α)-Kainic Acid (hydrate)
|
|
|
|
(-)-(α)-Kainic Acid (hydrate) is a potent excitotoxic agent that can induce seizures. (-)-(α)-Kainic Acid (hydrate) is also an agonist of ionotropic glutamate receptor subtypes. |
|
T68918 |
Phenytoin-d10
|
|
|
|
Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fospheny... |
|
TP2028 |
Galanin (1-29)(rat, mouse)
|
Galanin (1-29) (rat, mouse) |
|
|
Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats. |
|
T39207 |
L-803087 TFA
|
|
|
|
L-803087 TFA is a highly potent and selective agonist of the somatostatin sst4 receptor, exhibiting a Ki value of 0.7 nM. It displays a remarkable selectivity, being over 280-fold more preferential for the sst4 receptor ... |
|
T69780 |
VU6007477
|
|
|
|
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp,uu = 0.32;... |
|
T70896 |
PF05020182
|
|
|
|
PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemic... |
|
T37950 |
2-(Isopentylamino)naphthalene-1,4-dione
|
|
|
|
2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, r... |
|
TMIH-0024 |
10,11-Dihydro-10-hydroxycarbamazepine-d4
|
rac-Licarbazepine-d4 |
|
|
10,11-Dihydro-10-hydroxycarbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxycarbamazepine. 10,11-Dihydro-10-hydroxycarbamazepine has a CAS number of 29331-92-8. Licarbazepine is the pharmacologically act... |
|
T72748 |
(S,S)-BD-AcAc 2
|
(S,S)-Ketone Ester |
|
|
(S,S)-BD-AcAc 2 ((S,S)-Ketone Ester), an (S,S)-enantiomer of BD-AcAc 2, increases AcAc and acetone levels, inducing sustained ketosis and significantly delaying seizures associated with central nervous system oxygen toxi... |
|
T7720 |
CGP 37849
|
CGP-37849,CGP37849 |
NMDAR
,
iGluR
|
|
CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties. |
|
T70292 |
DDPM-2571 HCl
|
|
|
|
DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and... |
|
T26366L |
Prasterone sulfate sodium hydrate
|
Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate |
|
|
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activit... |
|
T37608 |
Riluzole-13C,15N2
|
Riluzole-13C,15N2 |
|
|
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic... |
|
T83963 |
Z-DEVD-FMK Caspase-3 Inhibitor
|
|
|
|
Z-DEVD-FMK, a Caspase-3 Inhibitor, is an irreversible, cell-permeable inhibitor of caspase-3/CPP32 that impedes tumor cell apoptosis. In vivo studies show it offers neuroprotection in rat hippocampi post-seizures and con... |
|
T73436 |
AK-IN-1
|
|
|
|
AK-IN-1, a competitive inhibitor for adenosine (Ado) but not for ATP, demonstrates significant inhibition of AK activity, achieving 86%, 87%, and 89% at concentrations of 2, 4, and 10 µM, respectively. This compound show... |
|
T38224 |
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
|
|
|
|
N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuriminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 μM, respectively). In vivo, DANA (30 μL of a 5 mM solution) reduces latency to f... |
|
T70186 |
Methazolamide-d6
|
|
|
|
Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal flu... |
|
T70063 |
GYKI 52466 HCl
|
|
|
|
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
|
T35432 |
α-Conotoxin ImI (trifluoroacetate salt)
|
|
|
|
α-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM)... |
