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T37118 |
ADP-Glucose (sodium salt)
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ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt) |
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ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.... |
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T37898 |
UDP-α-D-Glucose (sodium salt hydrate)
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UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation ... |
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T37899 |
UDP-β-D-Glucose (sodium salt)
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UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) . The activities of the UDP-β-D-glucose isomer are not known. |
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T37786 |
1-thio-β-D-Glucose (sodium salt)
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1-thio-β-D-Glucose is an analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position. The thiol group allows diverse chemical reactions, including click chemistry and polymerization. 1-thio-β-D-... |
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T35416 |
α-D-Glucose-1-phosphate (sodium salt hydrate)
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α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen... |
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T38843 |
Enavogliflozin
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DWP-16001 |
SGLT
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Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor. |
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T31976 |
Glymidine sodium
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Others
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Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion. |
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T7717 |
Sodium 2-oxopropanoate
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Sodium pyruvate |
Reactive Oxygen Species
,
Endogenous Metabolite
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Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease. |
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T15656 |
KGA-2727
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SGLT
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KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA... |
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T9590 |
T-1095
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SGLT
,
transporter
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T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). |
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T2389 |
Dapagliflozin
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BMS-512148 |
SGLT
,
HIF
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Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. |
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T2385 |
Ipragliflozin
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ASP1941 |
SGLT
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Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2. |
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T1766 |
Empagliflozin
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BI 10773 |
SGLT
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Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. |
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T3547 |
Sotagliflozin
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LX-4211,LP-802034 |
SGLT
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Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. |
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T4999 |
Ertugliflozin
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MK-8835,PF-04971729 |
SGLT
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PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). |
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T15244 |
Ertugliflozin L-pyroglutamic acid
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PF-04971729 L-pyroglutamic acid |
Others
,
SGLT
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Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatmen... |
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T5016 |
Tofogliflozin (hydrate)
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Tofogliflozin hydrate,CSG-452 hydrate |
SGLT
,
Reactive Oxygen Species
,
ROS
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Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2). |
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T1782 |
Canagliflozin
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JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 |
SGLT
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Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes. |
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T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
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BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate |
SGLT
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Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre... |
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T15752 |
Licogliflozin
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LIK066 |
SGLT
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Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2). |
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T16083 |
Mizagliflozin
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GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT
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Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... |
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T37985 |
D-Fructose-6-phosphate (sodium salt hydrate)
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D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base) |
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D-Fructose-6-phosphate (sodium salt hydrate) is a sugar intermediate in the glycolytic pathway produced by the isomerization of glucose 6-phosphate by glucose phosphate isomerase, and is used in cancer research. |
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T76279L1 |
Retatrutide sodium salt
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Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt |
Glucagon Receptor
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Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium s... |
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T1782L |
Canagliflozin hemihydrate
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JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 |
SGLT
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Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab... |
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T7217 |
Bexagliflozin
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THR-1442,EGT1442,EGT0001442 |
SGLT
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Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively |
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T35337L |
Teduglutide acetate
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Glucagon Receptor
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Teduglutide acetate, a GLP-2 analogue, maximizes small intestinal mucosal hypertrophy. Teduglutide acetate partially restores small intestinal epithelial function through an altered distribution of claudin-10, facilitati... |
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T13647 |
Dextran sulfate sodium salt (MW 4500-5500)
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DSS,Dextran sulfate sodium salt (MW 4500-5500) |
Apoptosis
,
HIV Protease
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Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. Dextran sulfate sodium salt (MW 4500-5500) inhibits human immunodeficiency virus replication by preve... |
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T36587 |
APTS
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8-Aminopyrene-1,3,6-trisulfonic acid trisodium |
Others
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8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively. It forms a ground state complex with viologen-type quenchers, inducing a red-shift i... |
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T17221 |
Velagliflozin
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SGLT
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Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2. |
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T30534 |
BMS-639432
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BMS-639432 is a potent sodium-glucose cotransporter type II (SGLT2) inhibitor. |
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T21399 |
Luseogliflozin
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TS71,TS-071,TS 71,TS071,TS-71,TS 071 |
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Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM. |
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T24708 |
Remogliflozin
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GSK189074,Remogliflozin A,GSK-189074,GSK 189074 |
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Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). |
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T29188 |
YM-543 trimethylamine
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ASP 543,ASP-543,ASP543 |
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YM-543, a sodium-glucose transporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes. |
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T28971 |
Tianagliflozin
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Tianagliflozin, a sodium/glucose cotransporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes. |
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T10957 |
Dapagliflozin impurity
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Others
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Dapagliflozin impurity is the enantiomer of Dapagliflozin, Dapagliflozin is a sodium glucose transporter 2 inhibitor. |
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T13647L |
Dextran sulfate sodium salt (MW 40000)
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Dextran sulfate sodium salt (MW 40000) is a glucose dehydrating polymer with a molecular weight of 40000. |
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T71340 |
Mizagliflozin sebacate
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Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from... |
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T13179 |
Tofogliflozin
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CSG452 |
Others
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Tofogliflozin is a highly specific inhibitor of sodium/glucose cotransporter 2 (SGLT2) (Kis: 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. IC50s: 2.9/14.9/6.4 nM (human/rat/mouse SGLT2)). |
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T15797 |
LX2761
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Others
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LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the... |
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T12892 |
SGL5213
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SGLT
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SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes. |
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TMIH-0013 |
(S)-Empagliflozin-d4
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(S)-Empagliflozin-d4 is a deuterated compound of (S)-Empagliflozin. (S)-Empagliflozin has a CAS number of 864070-44-0. Empagliflozin is a Sodium-Glucose Cotransporter 2 Inhibitor. The mechanism of action of empagliflozin... |
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T68236 |
TP0438836
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TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively. |
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T40141 |
Palmitic acid-13C16 sodium
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Palmitic acid-13C16 sodium |
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Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated prote... |
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T68922 |
YM543 free base
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YM543 free base, a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor, effectively reduces blood glucose levels and is suitable for diabetes research. |
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T34430 |
RU 24411
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RU24411,RU-24411 |
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RU 24411 is a synthetic 19-nor steroid compound. RU 24411 appeared as capable of stimulation of sodium transport as aldosterone in the absence of glucose. |
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T38539 |
Luseogliflozin hydrate
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TS 071 hydrate |
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Luseogliflozin (TS 071) hydrate, a second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor, exhibits selective potency and oral activity, with an IC50 of 2.26 nM. This compound is utilized in research for the... |
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T35619 |
Dapagliflozin-3-O-β-D-Glucuronide
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Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metab... |
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T70390 |
YM-543 choline
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YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and ... |
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T39423 |
Palmitic acid-13C sodium
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Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (... |
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T72143 |
Velagliflozin proline hydrate
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Velagliflozin proline hydrate, the clinical form of Velagliflozin, is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor exhibiting antidiabetic activity. By decreasing renal glucose reabsorption and promoting glyc... |
