|
T38685 |
C12-Sphingosine
|
C12-Sphingosine |
|
|
C12-Sphingosine is a short-chain homologue of Sphingosine. It effectively inhibits the activity of serine palmitoyltransferase in primary cultured cerebellar cells. |
|
T24044 |
Erythro-sphingosine, (+)-
|
L-Erythro-c18-sphingosine,L-Erythro-sphingosine |
|
|
Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 µM) and enhances Src kinase activity. |
|
T83883 |
Biotin Sphingosine
|
Biotinyl Sphingosine |
|
|
Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates. |
|
T37954 |
Sphingosine (d20:1)
|
Sphingosine (d20:1) |
|
|
Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, howe... |
|
T37955 |
Sphingosine-1-phosphate (d16:1)
|
Sphingosine-1-phosphate (d16:1) |
|
|
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO... |
|
T34693 |
Sphingosine phosphorylcholine
|
|
|
|
Sphingosine phosphorylcholine is a wound healing agent. |
|
T6085 |
PF-543
|
Sphingosine Kinase 1 Inhibitor II,PF 543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. |
|
T22917 |
L-threo-Sphingosine C-18
|
|
Others
|
|
L-threo-Sphingosine C-18 is a protein kinase C inhibitor. |
|
T81700 |
NBD Sphingosine
|
|
|
|
NBD Sphingosine (NBD-Sph), a fluorochrome-tagged sphingosine, is utilized in fluorescence assays for sphingosine kinases [1] [2]. |
|
T40849 |
C20 Ceramide
|
N-Arachidoyl-D-sphingosine |
Endogenous Metabolite
|
|
C20 Ceramide is a 20:0 ceramide found in the brain that crosses the blood-brain barrier to activate microglia and induce depressive-like behavior. |
|
T35803 |
C14 Ceramide (d18:1/14:0)
|
Cer(d18:1/14:0),N-Myristoyl-D-sphingosine |
|
|
C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's research. |
|
T21260 |
Psychosine
|
Sphingosine galactoside,Galactosylsphingosine,Galactosylsphingosine (d18:1) |
PKC
|
|
Psychosine (Galactosylsphingosine) is a PKC inhibitor, a substrate for the enzyme galactosylceramide cerebrosidase (GALC), and a potential biomarker of Krabbe's disease.Psychosine is highly cytotoxic and induces cell dea... |
|
T37436 |
C12-Ceramide
|
N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine |
|
|
C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activi... |
|
T8461 |
SKI V
|
|
Apoptosis
,
PI3K
,
S1P Receptor
|
|
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity |
|
T20827 |
C8-Ceramide
|
N-Octanoyl-D-erythro-Sphingosine |
|
|
C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides. |
|
T12436 |
PF-543 Citrate
|
Sphingosine Kinase 1 Inhibitor II Citrate |
S1P Receptor
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ). |
|
T8840 |
PF-543 hydrochloride
|
PF-543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
|
T16128 |
MP-A08
|
|
S1P Receptor
|
|
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively). |
|
T4658 |
MHP
|
Methyl caprooyl tyrosinate |
S1P Receptor
|
|
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. |
|
T6673 |
SKI II
|
SphK-I2 |
Apoptosis
,
Wnt/beta-catenin
,
S1P Receptor
|
|
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2. |
|
TQ0138 |
K145 hydrochloride
|
|
Apoptosis
,
S1P Receptor
|
|
|
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T6750 |
Opaganib
|
ABC294640 |
S1P Receptor
|
|
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM). |
|
T21658 |
ARN14974
|
|
Others
|
|
ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1]. |
|
T83910 |
S1PL-IN-31
|
Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 |
|
|
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem... |
|
T83880 |
C18 Ceramide-1-phosphate (d18:1/18:0) ammonium
|
Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate |
|
|
C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin known to promote the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (H... |
|
T9014 |
SKI-178
|
|
Apoptosis
,
S1P Receptor
|
|
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ... |
|
TQ0064 |
Peretinoin
|
NIK333 |
HCV Protease
,
Retinoid Receptor
,
S1P Receptor
,
Autophagy
|
|
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
|
T12148 |
N-Desmethyltamoxifen hydrochloride
|
|
Estrogen Receptor/ERR
,
Endogenous Metabolite
,
PKC
|
|
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans. |
|
T6923 |
Ozanimod
|
RPC-1063 |
S1P Receptor
,
LPL Receptor
|
|
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
|
T23045 |
N,N-Dimethylsphingosine
|
|
Others
|
|
sphingosine kinase (SphK) inhibitor |
|
T38214 |
1-Deoxysphingosine (m18:1(4E))
|
1-Deoxysphingosine (m18:1(4E)) |
|
|
1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine durin... |
|
T37928 |
13C6 Glucosylsphingosine (d18:1)
|
|
|
|
13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.... |
|
T27189 |
DL-threo dihydrosphingosine
|
DL-Safingol,DTD,DL threo dihydrosphingosine |
|
|
DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- an... |
|
T38291 |
C24 Phytosphingosine (t18:0/24:0)
|
|
|
|
C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t... |
|
T38354 |
Lactosylsphingosine (d18:1)
|
Lactosylsphingosine (d18:1) |
|
|
Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent man... |
|
T38090 |
3'-sulfo Galactosylsphingosine (ammonium salt)
|
|
|
|
3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM... |
|
T35806 |
N-Stearoylsphingosine
|
C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide |
Phosphatase
|
|
N-Stearoylsphingosine is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylati... |
|
T27106 |
CYM50374
|
|
|
|
CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM. |
|
T27864 |
LX-2931
|
LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305 |
S1P Receptor
|
|
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis. |
|
T10305 |
Amiselimod hydrochloride
|
MT-1303 hydrochloride |
S1P Receptor
,
LPL Receptor
|
|
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator. |
|
T63047 |
SLP9101555
|
|
S1P Receptor
,
LPL Receptor
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace... |
|
T9992 |
SphK1&2-IN-1
|
|
S1P Receptor
|
|
SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects. |
|
T12086 |
Mocravimod hydrochloride
|
KRP-203 |
Others
,
LPL Receptor
|
|
|
|
T15031 |
CYM50260
|
|
Others
,
LPL Receptor
|
|
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
|
TQ0227 |
Etrasimod
|
APD334 |
S1P Receptor
,
LPL Receptor
|
|
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). |
|
T7360 |
GSK2018682
|
|
S1P Receptor
,
LPL Receptor
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). |
|
T2026 |
CYM5442
|
|
S1P Receptor
,
LPL Receptor
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine. |
|
T28643 |
Ex26
|
S1P1-IN-Ex26 |
S1P Receptor
|
|
Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling.Ex26 can be used in experimental autoimmune encep... |
|
T9464 |
CYM50358
|
|
LPL Receptor
|
|
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM. |
