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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
TP1604L	Thioredoxin reductase peptide acetate	Thioredoxin reductase peptide acetate(950890-23-0 free base)	Others
	Thioredoxin reductase peptide acetate corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active...		Others
TP1604	Thioredoxin reductase peptide
	Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfi...
TP1375	Thioredoxin reductase peptide TFA
	Thioredoxin reductase peptide TFA corresponds to residues 53-67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research..
T13230	TXNIP-IN-1		Others
			Others
T5481	TRi-1		Others
	TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy		Others
T20168	Aurothiomalate sodium	Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others , PKC
	Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ...		Others , PKC
T9118	KEA1-97		Apoptosis , Others , Caspase
	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ...		Apoptosis , Others , Caspase
T4414	Eprenetapopt	APR-246,PRIMA-1Met	Apoptosis , Others , Ferroptosis , p53 , Autophagy
	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...		Apoptosis , Others , Ferroptosis , p53 , Autophagy
T60446	LCS3		Apoptosis , Glutathione reductase
	LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, in...		Apoptosis , Glutathione reductase
T2283	PX-12	IV-2,PX12	Thioredoxin
	PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...		Thioredoxin
T29018	TrxR inhibitor D9	D9,TrxR-IN-D9
	TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).
T23166	PMX 464		Others
	inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system		Others
T24593	PAO-PDT	PAO PDT
	PAO-PDT is a highly selective thioredoxin reductase inhibitor.
T28906	T6603185	T-6603185,T 6603185
	T6603185 is a novel inhibitor of peroxiredoxin (Prx) and thioredoxin (Trx) systems.
T70131	TPP2a bromide
	TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor.
T11130	DVD-445		Others
	Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M.		Others
T34922	TRFS-red	TRFSred
	TRFS-red is the first red emission off-on probe for thioredoxin reductase.
T33413	Mito-TRFS	MitoTRFS
	Mito-TRFS is the first off-on probe for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells.
T40946	Seph-PAO
	Seph-PAO, a modified form of polyalphaolefin (PAO) compound, is created by coupling a sepharose fluorophore. Its primary application lies in the detection of thioredoxin reductase (TrxR).
T39048	Sel-green
	Sel-green is a selective selenol fluorescent probe used for quantifying the selenocysteine (Sec) content in the selenoenzyme thioredoxin reductase, as well as imaging endogenous Sec in live HepG2 cells.
T75351	TP-TRFS
	TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR) [1] .
T39915	Trx-red	Trx-red,NBL-SS perchlorate
	Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derived from the nile blue fluorophore. It is specifically designed for imaging thioredoxin (Trx) in live cells and in vivo, with excitation and emission w...
T62021	TrxR-IN-2
	TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma.
T61647	TrxR-IN-5
	TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A...
T79198	S-Gem		Nucleoside Antimetabolite/Analog
	S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine [1].		Nucleoside Antimetabolite/Analog
T36399	PAO-Nap
	PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting o...
T73825	TRFS-green
	TRFS-green, a highly selective off-on fluorescent probe, is designed for the specific imaging of thioredoxin reductase (TrxR) in living cells, exhibiting its maximum absorbance at approximately 373 nm [1].
T39664	Ethaselen	BBSKE
	Ethaselen (BBSKE), a selective thioredoxin reductase (TrxR) inhibitor, is orally active with IC50s of 0.5 and 0.35 μM for wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique sele...
T62294	SRI-37330 hydrochloride
	SRI-37330 hydrochloride is an orally active thioredoxin-interacting protein (TXNIP) inhibitor. hydrochloride can be used to study type 2 diabetes.
T73512	ZC0109
	ZC0109, a dual inhibitor targeting IDO1 and Thioredoxin Reductase 1 (TrxR1) with IC50 values of 50 nM and 3.0 μM respectively, effectively promotes ROS accumulation and arrests the cell cycle at the G1/S phase, culminati...
T78158	MitoCur-1		Others
	MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun...		Others
T35811	CAY10410
	CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a pot...
T83871	Ferroptocide
	Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cell...

Compounds

Thioredoxin reductase peptide acetate

TP1604L

Synonym: Thioredoxin reductase peptide acetate(950890-23-0 free base)

Target: Others

Thioredoxin reductase peptide

TP1604

Synonym:

Target:

Thioredoxin reductase peptide TFA

Aurothiomalate sodium

T20168

Synonym: Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Apoptosis, Others, Caspase

Eprenetapopt

T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

LCS3

T60446

Synonym:

Target: Apoptosis, Glutathione reductase

PX-12

T2283

Synonym: IV-2,PX12

Target: Thioredoxin

TrxR inhibitor D9

T29018

Synonym: D9,TrxR-IN-D9

Synonym: T-6603185,T 6603185

Synonym: Trx-red,NBL-SS perchlorate

Target: Nucleoside Antimetabolite/Analog

SRI-37330 hydrochloride

カタログ番号	製品名	別名	ターゲット
T5372	L-SelenoMethionine	L-(+)-Selenomethionine	Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite
	L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase.

天然物製品

L-SelenoMethionine

T5372

Synonym: L-(+)-Selenomethionine

Target: Apoptosis, Amino Acids and Derivatives, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00382	Thioredoxin/TRX Protein, Mouse, Recombinant	Mouse	E. coli
	Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act ...
TMPY-02250	Thioredoxin/TRX Protein, Human, Recombinant	Human	E. coli
	Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act ...
TMPY-02084	Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanot...
TMPY-02723	TXNL4B Protein, Human, Recombinant (His)	Human	E. coli
	Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in c...
TMPH-00739	Thioredoxin-1 Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
TMPJ-01404	TMX2 Protein, Human, Recombinant (His)	Human	E. coli
	TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of ...
TMPY-02572	TXNDC17 Protein, Human, Recombinant	Human	E. coli
	Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa...
TMPJ-01098	PRDX4 Protein, Human, Recombinant (His)	Human	E. coli
	Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alk...
TMPY-06696	TXNDC15 Protein, Human, Recombinant (His)	Human	HEK293
	TXNDC15 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 32.96 kDa. Accession number: NP_078991.3
TMPY-05058	TMX1 Protein, Human, Recombinant (mFc)	Human	HEK293
	As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in t...
TMPY-02271	TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)	Human	E. coli
	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat...
TMPY-02797	TXNL4A Protein, Human, Recombinant (His)	Human	E. coli
	DIM1, also known as TXNL4A, is a member of the Dim protein family. The Dim protein family is composed of two classes, DIM1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their ro...
TMPJ-00720	TXNDC12 Protein, Human, Recombinant (His)	Human	Human Cells
	Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defens...
TMPJ-00826	TXN Protein, Human, Recombinant (His)	Human	E. coli
	Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates...
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His)	Human	Human Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox...
TMPH-00072	2-Cys Prx A Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	Yeast
	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide...
TMPH-00078	Beta-amylase 1, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Beta-amylase activity. Can use p-nitrophenyl maltopentaoside (PNPG5) as substrate only in reduced form. Can play a minor role in the starch degradation and maltose metabolism in chloroplasts during the night. More active...
TMPJ-01124	PDIA6 Protein, Human, Recombinant (His)	Human	Human Cells
	Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br...
TMPJ-00934	PRDX3 Protein, Human, Recombinant	Human	E. coli
	Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and hu...
TMPH-03443	GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	E. coli
	Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres...
TMPH-02196	TXNDC5 Protein, Human, Recombinant (GST)	Human	E. coli
	Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
TMPH-02197	TXNDC5 Protein, Human, Recombinant	Human	E. coli
	Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
TMPY-05169	Peroxiredoxin 2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm pro...
TMPY-02462	Peroxiredoxin 5 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Peroxiredoxin-5, also known as Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5 and ACR1, is cytoplasm ...
TMPY-02200	Peroxiredoxin 2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm pro...
TMPY-02208	Peroxiredoxin 5 Protein, Human, Recombinant (His)	Human	E. coli
	Peroxiredoxin-5, also known as Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5 and ACR1, is cytoplasm ...
TMPH-02198	TXNRD2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
TMPJ-00461	PDIA5 Protein, Human, Recombinant (His)	Human	Human Cells
	Protein disulfide-isomerase A5 is a 519 amino acids protein that belongs to the protein disulfide isomerase family.It contains 3 thioredoxin domains.It can catalyze the rearrangement of -S-S- bonds in proteins.
TMPJ-01225	PDILT Protein, Human, Recombinant (His)	Human	Human Cells
	Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid ...
TMPY-01276	Peroxiredoxin 1 Protein, Human, Recombinant (His)	Human	E. coli
	Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is...
TMPY-02372	Peroxiredoxin 1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is...
TMPJ-01268	ERP27 Protein, Human, Recombinant (His)	Human	Human Cells
	Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thio...
TMPH-02200	TXNIP Protein, Human, Recombinant (B2M & His)	Human	in vitro E. coli expression system
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPH-02929	TXNIP Protein, Mouse, Recombinant (His)	Mouse	Yeast
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPY-02890	ERP27 Protein, Human, Recombinant (mFc)	Human	HEK293
	ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide...