|
T5051 |
Isopropamide Iodide
|
|
AChR
|
|
Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor antagonist which can be applied to the t... |
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T38612 |
Linaprazan glurate
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|
Others
|
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases. |
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T15500 |
HPi1
|
|
Others
,
Antibacterial
|
|
HPi1 is a selective and orally active antimicrobial against Helicobacter pylori (IC50: 0.24 μM and a MIC of 0.08-0.16 μg/mL). HPi1 is inactive against other Xaliproden, including the gut commensals, Lactobacillus reuteri... |
|
T0044 |
Oxethazaine
|
Oxetacaine |
HBV
,
Sodium Channel
|
|
Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain. |
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T6710 |
Troxipide
|
Aplace |
Others
|
|
Troxipide (Aplace), a new-type systemic non-antisecretory gastric cytoprotective agent, which is mucus-secreting, anti-ulcer, and anti-inflammatory properties irrespective of pH of stomach or duodenum. |
|
T1562 |
Rebamipide
|
Proamipide,OPC12759 |
Free radical scavengers
,
COX
,
Prostaglandin Receptor
|
|
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... |
|
T8388 |
Vonoprazan
|
TAK-438 (free base) |
Proton pump
|
|
Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis |
|
T0157 |
Roxatidine Acetate hydrochloride
|
HOE 760,Roxatidine Acetate HCl |
Histamine Receptor
|
|
Roxatidine Acetate hydrochloride (HOE 760) is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation. |
|
T6928 |
Pantoprazole
|
SKF96022,BY1023 |
Apoptosis
,
Proton pump
,
Autophagy
|
|
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
|
TP1035 |
Cyclic somatostatin
|
SRIF-14,Somatostatin-14 |
Others
|
|
Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions. |
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T19763 |
Cetraxate hydrochloride
|
DV-1006,DV 1006,Cetraxate HCl,DV1006 |
Serine/threonin kinase
|
|
Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect. |
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T21254 |
Vonoprazan Fumarate
|
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 |
Proton pump
|
|
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... |
|
T0161 |
Pantoprazole Sodium Hydrate
|
SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis
,
Potassium Channel
,
Proton pump
,
Autophagy
|
|
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
|
T6929 |
Pantoprazole sodium
|
Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc |
Apoptosis
,
Others
,
Proton pump
,
HIF
,
Autophagy
|
|
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... |
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T10124 |
Antiulcer Agent 1
|
|
Others
|
|
Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration. |
|
T76577 |
Antiulcer Agent 2
|
|
|
|
Antiulcer Agent 2, a tetrapeptide comprising aspartic acid, alanine, histidine, and lysine, localizes at the N-terminal of human albumin. This compound shows promise in treating ulcers and producing active oxygen [1] [2]... |
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T29015 |
Trithiozine
|
Tresanil,Sulmetozine,Tritiozinum,Tritiozine,Tritiozina |
Others
|
|
Trithiozine (Tritiozinum) exhibits antisecretory and antiulcer capacity. Trithiozine can be used for research on the treatment of peptic ulcer disease and hypersecretory disorders. |
|
T28665 |
Saviprazole
|
Hoe731,Hoe 731,Hoe-731 |
Proton pump
|
|
Saviprazole (Hoe-731), a proton pump inhibitor, is used potentially for treatment of gastric ulcer. |
|
T31195 |
Dalcotidine
|
KU 1257,KU-1257 |
Histamine Receptor
|
|
Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value f... |
|
T5008 |
Teprenone
|
Tetraprenylacetone,Geranylgeranylacetone |
HSP
|
|
Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). |
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T77618 |
COX-2-IN-34
|
|
COX
|
|
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice. |
|
T4510 |
Polaprezinc
|
Zinc L-carnosine |
Others
|
|
Polaprezinc is an bioavailable chelate comprised of zinc and L-carnosine, known for its gastrointestinal protective properties, as well as its anti-ulcer, antioxidant, and anti-inflammatory effects. |
|
T12215 |
Nexopamil racemate
|
(Rac)-Nexopamil |
Calcium Channel
,
5-HT Receptor
|
|
|
|
T6548 |
Irsogladine
|
Dicloguamine |
PDE
,
AChR
|
|
Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. |
|
T10872L |
CP 96021
|
|
5-HT Receptor
|
|
CP 96021 is a group of 5-HT1 receptors and 5-HT2 receptors antagonists that have anti-inflammatory properties and are non-non-self anti-ulcer compounds for the treatment of gastrointestinal tract and respiratory asthma. |
|
T6349 |
Sitafloxacin Hydrate
|
DU-6859a,DU6859a hydrate |
Antibacterial
,
Antibiotic
|
|
Sitafloxacin Hydrate (DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. |
|
T1639 |
Amlexanox
|
CHX3673,Amoxanox,AA673 |
IL Receptor
,
FGFR
,
Others
,
IκB/IKK
|
|
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan... |
|
T77617 |
MMP-9-IN-6
|
|
MMP
|
|
MMP-9-IN-6 is an MMP-9 inhibitor with an IC50 value of 50 μM and good anti-ulcer efficacy.MMP-9-IN-6 has potential anti-tumor activity and can be used to study tissue remodeling, wound repair and atherosclerosis. |
|
T1756L |
Ilaprazole
|
IY81149,IY 81149,IY-81149 |
Proton pump
,
TOPK
|
|
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm... |
|
T16865 |
SCH28080
|
|
ATPase
,
Proton pump
|
|
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... |
|
T21385 |
Cinitapride
|
Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor
|
|
Cinitapride (Blaston) is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia. Cinitapride acts as an antag... |
|
T36454 |
1-Stearoyl-rac-glycerol
|
|
|
|
1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenes... |
|
T0786 |
Clidinium bromide
|
Ro 2-3773 |
AChR
|
|
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
|
T23725 |
Amicoumacin A
|
|
|
|
Amicoumacin A has antibacterial activity. It also strongly suppresses inflammatory and ulcer activity. |
|
T33710 |
Nocloprost
|
|
|
|
Nocloprost is a prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. |
|
T10008 |
BTM-1086
|
|
Others
|
|
BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent. |
|
T34087 |
Plaunotol
|
Kelnac,Plaunotolum |
|
|
Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing. |
|
T28613 |
RP73870
|
RP 73870,RP-73870 |
|
|
RP73870 is a gastrin/cholecystokinin-B receptor antagonist and H2 receptor antagonist with potent anti-ulcer activity. |
|
T34936 |
Tridihexethyl chloride
|
Propethonum,Pathilon,Tridihexethyl |
|
|
Tridihexethyl is an anticholinergic, antimuscarinic, and antispasmolytic drug, which can be used to treat acquired nystagmus or peptic ulcer disease. |
|
T24728 |
Rosaprostol
|
C 83 |
|
|
Rosaprostol is an agent of the anti-ulcer drug. |
|
T31743 |
Famotine hydrochloride
|
Famotine HCl,UK-2054 |
|
|
Famotine Hydrochloride is a histamine H2 receptor antagonist that suppresses acid production in the stomach and commonly treats peptic ulcer disease and gastroesophageal reflux disease. |
|
T32599 |
Lauroylglycyrrhetinic acid
|
BX 24,BX24,BX-24 |
|
|
Lauroylglycyrrhetinic acid, an analog of carbenoxolone, can be used in the treatment of stomach ulcer. |
|
T70127 |
Famotine
|
|
|
|
Famotine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. |
|
T38058 |
Cimetidine sulfoxide
|
|
|
|
Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorr... |
|
T68725 |
Famotidine propanamide
|
|
|
|
Famotidine propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. |
|
T70090 |
Nizatidine amide
|
|
|
|
Nizatidine amide is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. |
|
T0157L |
Roxatidine acetate
|
|
|
|
Roxatidine acetate is an anti-ulcer agent and histamine antagonist that inhibits gastric acid secretion. Compared to other similar drugs, Roxatidine acetate has an improved safety profile, in part because lower doses of ... |
|
T24254 |
KB-5492 anhydrous
|
KB-5492,KB5492,KB 5492 |
|
|
KB 5492 is an agent of anti-ulcer. It preventing cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion. |
|
T69801 |
AU-461
|
|
|
|
AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent. |
|
T25728 |
Limaprost alfadex
|
Opalmon,OP 1306 - alpha-cyclodextrin,Prorenal |
|
|
Limaprost alfadex is an oral medicine for the circulatory system (for confinement-related thromboangiitis ulcer, anaphrodisia, sharp pain and ischemia characteristics symptom, the improvement of subjective symptom and wa... |
