|
T1765 |
Erastin
|
|
Ferroptosis
,
VDAC
|
|
Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product... |
|
T3572 |
NSC 15364
|
1,3-Bis(4-aminophenyl)urea,NSC15364 |
Apoptosis
,
Others
,
VDAC
|
|
NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System. |
|
T18975 |
DIDS sodium salt
|
MDL101114ZA |
VDAC
,
ABC
|
|
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. |
|
T2141 |
Mecamylamine hydrochloride
|
Inversine,Mevasin |
AChR
|
|
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension. |
|
T0825 |
Ebselen
|
SPI-1005,PZ-51,CCG-39161 |
Phosphatase
,
Virus Protease
,
Calcium Channel
,
COX
,
HIV Protease
|
|
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... |
|
T20341 |
DNDS
|
|
CFTR
|
|
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR). |
|
T11979 |
McN5691
|
MCN 5691,RWJ26240 |
Calcium Channel
|
|
McN5691 (RWJ26240) is a voltage-dependent calcium channel blocker with antihypertensive activity that can be used in the study of diseases caused by vascular smooth muscle abnormalities. |
|
T13428 |
(5R)-BW-4030W92
|
|
Sodium Channel
|
|
(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer. (5R)-BW-4030W92 is an orally available, non-selective, voltage-dependent and use-dependent sodium channel antagonist for the study of neurological disor... |
|
T17227 |
Vernakalant Hydrochloride
|
RSD1235 hydrochloride |
Potassium Channel
,
Sodium Channel
|
|
Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. |
|
T0596 |
Phenylhydantoin
|
5-Phenylhydantoin |
Others
|
|
5-Phenylhydantoin (5-Phenylhydantoin) is a metabolite of Mephenytoin. 5-Phenylhydantoin has been shown to bind to voltage-dependent sodium channels (NVSC) and has anti-epileptic properties. |
|
T21263 |
Amlodipine maleate
|
Amlodipine (+-)-form maleate,Amvaz |
Calcium Channel
|
|
Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hy... |
|
T30188L |
Atagabalin HCl
|
PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base） |
Calcium Channel
|
|
Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia. |
|
T7502L |
PF 05089771
|
PF-05089771,PF05089771 |
Sodium Channel
|
|
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. |
|
T26778 |
Besipirdine
|
HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493 |
Sodium Channel
,
Adrenergic Receptor
|
|
Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni... |
|
T26778L |
Besipirdine hydrochloride
|
HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base) |
Adrenergic Receptor
|
|
Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibit... |
|
T0030 |
Bupivacaine hydrochloride
|
Vivacaine,Bupivacaine HCl |
Sodium Channel
|
|
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol... |
|
T13287 |
VBIT-4
|
|
VDAC
|
|
VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular dis... |
|
T68060 |
Elgodipine
|
|
|
|
Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression ... |
|
T40376 |
L-Phenylalanine-15N
|
(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel
|
|
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dep... |
|
T23274 |
RuBi-4AP
|
|
Others
|
|
voltage-dependent K+ channel blocker |
|
T70199 |
Enecadin HCl
|
|
|
|
Enecadin HCl is a voltage-dependent sodium and calcium channel blocker. |
|
T16447 |
β-Amino Acid Imagabalin Hydrochloride
|
PD-0332334 |
Calcium Channel
|
|
β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit. |
|
T71281 |
Nerispirdine
|
|
|
|
Nerispirdine is a biochemical that inhibits batrachotoxin binding to voltage-dependent sodium channels. |
|
T26092 |
Risotilide
|
|
|
|
Risotilide is a voltage-dependent potassium channel inhibitor. It can prolong cardiac action potentials and refractory periods. |
|
T16487 |
PF-05241328
|
|
Others
|
|
PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM). |
|
T19788 |
Piretanide
|
Eurelix,Tauliz,Arelix |
|
|
Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic. |
|
T70691 |
ITP-2
|
|
|
|
ITP-2 is a selective activator of hERG channels. ITP-2 causes large depolarizing shifts in the midpoint of voltage-dependent inactivation and hyperpolarizing shifts in the voltage-dependence of activation. |
|
T36808 |
UK 59811 hydrochloride
|
|
|
|
Blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).
Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagon... |
|
T10209 |
A-887826
|
|
Others
|
|
|
|
T80439 |
GTx1-15
|
|
Sodium Channel
|
|
GTx1-15, an inhibitor cystine knot (ICK) peptide, antagonizes the voltage-dependent calcium channel Cav3.1, as well as voltage-dependent sodium channels Nav1.3 and Nav1.7 [1]. |
|
T26564 |
ADCI
|
SGB-017,SGB017,SGB 017 |
|
|
ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabo... |
|
TP1967 |
Phrixotoxin 3
|
|
|
|
Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner. |
|
T28346 |
PD-217014 HCl
|
PD 217014,PD217014,PD-217,014,PD-217014 |
|
|
PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic ac... |
|
T14150 |
AKOS-22
|
|
Others
|
|
AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 ol... |
|
T19591 |
Triamterene D5
|
|
Others
|
|
Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic. |
|
T27032 |
CK59
|
CK-59,CK 59 |
|
|
CK59 is a reversible inhibitor of calcium-calmodulin-dependent kinase II (CaMKII). CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The... |
|
T13286 |
VBIT-3
|
|
Others
|
|
VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurod... |
|
TP2118 |
SNX-482
|
SNX 482 |
|
|
Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses. |
|
T68125 |
(Rac)-PD0299685
|
(Rac)-PF-299685 |
Calcium Channel
|
|
(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases. |
|
T23210 |
Quinacrine (dihydrochloride hydrate)
|
Quinacrine (hydrochloride hydrate) (83-89-6 free base) |
Others
|
|
Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of pr... |
|
T80184 |
GsAF-II
|
|
Sodium Channel
|
|
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium channels [1]. |
|
T76392 |
β-Bag cell peptide
|
|
|
|
β-Bag cell peptide, a neuroactive peptide, elevates cyclic AMP levels and reduces the amplitudes of voltage-dependent potassium currents [1] in bag cell neurons. |
|
T80980 |
Tityustoxin-Kα
|
TsTx-Kα |
|
|
Tityustoxin-Kα (TsTx-Kα) acts as an inhibitor of potassium voltage-gated channels, exhibiting a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons [1]. |
|
T68918 |
Phenytoin-d10
|
|
|
|
Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fospheny... |
|
T23652 |
AFD-21
|
AFD21,NS-2 Class 1 antiarrhythmic agent |
|
|
AFD-21 is a class I antiarrhythmic drug. It binds to sodium channels in their inactivated state and exerts use- and voltage-dependent inhibition of sodium channels with unbinding rates comparable to those of class I anti... |
|
T28160 |
Nerispirdine HCl
|
HP-184,HP 184,Nerispirdine hydrochloride,HP184 |
|
|
Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11... |
|
T80434 |
Heteropodatoxin-2
|
|
Potassium Channel
|
|
Heteropodatoxin-2, a 30-amino acid peptide, inhibits the Kv4.2 current in Xenopus laevis oocytes through a voltage-dependent mechanism, exhibiting reduced blocking at more positive potentials [1]. |
|
T80028 |
Iberiotoxin TFA
|
|
Potassium Channel
|
|
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet it does not inhibit other types of voltage-dependent ion chann... |
|
T11240 |
Ethacrynic acid D5
|
|
Others
|
|
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effec... |
|
T79280 |
Nav1.3 channel inhibitor 1
|
|
Sodium Channel
|
|
Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM. It has the ability to cross the blood-brain barrier, making it applicabl... |
