|
T25175 |
BRD 9757
|
BRD9757,N-Hydroxy-1-cyclopentene-1-carboxamide,BRD-9757 |
HDAC
|
|
BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM). |
|
T10602L |
BRD 4354
|
|
HDAC
|
|
BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively. |
|
T10603 |
BRD-6929
|
|
HIV Protease
,
HDAC
|
|
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin... |
|
T26901 |
BRD-9526
|
BRD 9526 |
|
|
BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh). |
|
T26894 |
BRD0209
|
BRD-0209,BRD 0209 |
GSK-3
|
|
BRD0209 is a highly selective and potent GSK3 inhibitor. |
|
T30577 |
BRD0418
|
BRD 0418,BRD-0418 |
Others
|
|
BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it. |
|
T23820 |
BRD32048
|
BRD-32048,BRD 32048 |
DNA/RNA Synthesis
|
|
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor. |
|
T2292 |
FPH2
|
BRD-9424 |
Others
|
|
FPH2 (BRD-9424) (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes. |
|
T6506 |
FPH1
|
BRD-6125 |
Others
|
|
FPH1 (BRD-6125) (BRD-6125) can promote the expansion of iPS-derived hepatocytes. |
|
T70600 |
BRD-7880
|
|
|
|
BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C. |
|
T35872 |
BRD-8000.3
|
|
|
|
BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent known for its specific inhibition of EfpA. It exhibits potent activity against wild-type strains and proves to be a valuable tool in tuberculosis rese... |
|
T10602 |
BRD 4354 ditrifluoroacetate
|
BRD 4354 ditrifluoroacetate (315698-07-8 free base) |
HDAC
|
|
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM). |
|
T10605 |
BRD-K98645985
|
|
Others
|
|
BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 µM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning. |
|
T69692 |
BRD-K25923209
|
|
|
|
BRD-K25923209 is a novel inhibitor of BAF transcriptional repression. |
|
T2102 |
FH1
|
BRD-K4477,NSC 12407 |
Others
|
|
FH1 (NSC-12407) (BRD-K4477), a small molecule, enhances the functions of hepatocytes and promotes differentiation hepatocytes derived by iPS. |
|
T41198 |
BRD PHOTAC-I-3
|
|
|
|
BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ... |
|
T16905 |
SNIPER(BRD)-1
|
|
Others
|
|
SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway an... |
|
T10604 |
BRD-IN-3
|
|
Others
|
|
BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ. |
|
T61361 |
BRD-8899
|
|
|
|
BRD-8899 is a STK33 inhibitor, with an IC 50 of 11 nM [1]. |
|
T2353 |
BRD7116
|
BRD7716 |
DNA gyrase
,
Antibacterial
|
|
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity. |
|
T26897 |
BRD2492
|
|
HDAC
|
|
BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, HDAC3 and HDAC6.BRD2492 inhibits the growth of breast cancer... |
|
T30579 |
BRD4097
|
|
HDAC
|
|
BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insulin resistance, help promote cognitive function and enhance l... |
|
T30583 |
BRD6897
|
BRD-6897,BRD 6897 |
|
|
BRD6897 is a mitochondrial content inducer. |
|
T30582 |
BRD56491
|
BRD-56491,BRD 56491 |
|
|
BRD56491 is a non-toxic reactive oxygen species (ROS) enhancer that strongly elevates markers of oxidative stress without causing cell death. |
|
T26899 |
BRD50837
|
BRD-50837,BRD 50837 |
|
|
BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh). |
|
T30584 |
BRD9092
|
BRD 9092,BRD-9092 |
|
|
BRD9092 is an enhancer of reactive oxygen species that are nontoxic or cause genotype-selective cell death. |
|
T26900 |
BRD7539
|
BRD-7539,BRD 7539 |
|
|
BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 shows to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM). |
|
T26896 |
BRD1652
|
BRD-1652,BRD 1652 |
|
|
BRD1652 is a highly selective and potent GSK3 inhibitor. |
|
T25176 |
BRD2577
|
BRD-2577,BRD 2577 |
|
|
BRD2577 is an HDAC inhibitor, by suppressing multiple HDAC enzymes and modulating acetylation levels in cells. |
|
T9329 |
BRD0639
|
|
Histone Methyltransferase
|
|
BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities depend... |
|
T21715 |
BRD6688
|
|
HDAC
|
|
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes |
|
T23821 |
BRD4884
|
BRD-4884,BRD 4884 |
|
|
BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes. |
|
T30581 |
BRD5459
|
BRD-5459,BRD 5459 |
|
|
BRD5459 is a kind of reactive oxygen species enhancer that is non-toxic or leads to genotype selective cell death. Brd5459 can selectively kill cancer cells in various in vitro and in vivo models. |
|
T26898 |
BRD2879
|
BRD 2879,BRD-2879 |
|
|
BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM). |
|
T30578 |
BRD3067
|
BRD-3067,BRD 3067 |
|
|
BRD3067 is a negative control for tubastatin A. |
|
T6793 |
BRD7552
|
|
Others
|
|
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. |
|
T7378 |
BRD9539
|
|
Histone Methyltransferase
|
|
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM |
|
T10608 |
BRD5648
|
(R)-BRD0705 |
GSK-3
|
|
|
|
T69644 |
DUN73423
|
RET-IN-21 |
c-RET
|
|
DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer. |
|
T14778 |
BRD6989
|
|
IL Receptor
,
CDK
,
Interleukin
|
|
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex... |
|
T1923 |
BRD4770
|
|
Histone Methyltransferase
|
|
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. |
|
T6421 |
BRD73954
|
|
HDAC
|
|
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
|
T14779 |
BRD7389
|
|
SGK
,
FLT
,
Pim
,
CDK
,
S6 Kinase
,
DAPK
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
|
T26895 |
BRD0476
|
BRD-0476,ML 187,ML187,ML-187,BRD 0476 |
|
|
BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell ... |
|
T8233 |
BRD3308
|
|
Apoptosis
,
HIV Protease
,
HDAC
|
|
BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK. |
|
T10606 |
BRD0705
|
|
GSK-3
|
|
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM). |
|
T8342 |
BRD9876
|
|
Others
,
Kinesin
,
Microtubule Associated
|
|
BRD9876 is a selective inhibitor of MM1S growth. |
|
T12664 |
(Rac)-BRD0705
|
|
Others
|
|
(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (IC50 of 66 nM and a Kd of 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold... |
|
T69691 |
Pocenbrodib
|
FT-7051,P-300 |
Epigenetic Reader Domain
|
|
Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research. |
|
T17697 |
BRD7-IN-1
|
|
Epigenetic Reader Domain
|
|
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 through linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1]. |
