|
T40004 |
Pomalidomide-C7-NH2 hydrochloride
|
|
Others
|
|
Pomalidomide-C7-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology. |
|
T39701 |
Pomalidomide-C7-COOH
|
Pomalidomide-C7-COOH |
|
|
Pomalidomide-C7-COOH is a chemically synthesized E3 ligase cereblon ligand-linker conjugate, utilized as an intermediate compound for the synthesis of PROTAC BCL-XL degraders. |
|
T39511 |
Thalidomide-O-C7-NH2
|
Thalidomide-O-C7-NH2 |
|
|
Thalidomide-O-C7-NH2 is a synthesized conjugate compound comprising an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Thalidomide and a linker that is commonly employed in PROTAC... |
|
T39645 |
Thalidomide-O-C7-acid
|
Thalidomide-O-C7-acid |
|
|
Thalidomide-O-C7-acid is a compound created through the synthesis of an E3 ligase ligand-linker conjugate. It consists of a cereblon ligand derived from Thalidomide, combined with a linker that is commonly employed in PR... |
|
T39838 |
(S,R,S)-AHPC-C7-amine
|
VH032-C7-amine,(S,R,S)-AHPC-C7-amine |
|
|
(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed f... |
|
T82988 |
AP-C7
|
|
|
|
AP-C7 is a selective inhibitor of cGMP-dependent protein kinase II (cGKII) with a pIC50 value of 5.0, demonstrating only weak inhibition of cGKII-dependent anion secretion [1]. |
|
T18671 |
(S,R,S)-AHPC-Me-C7 ester
|
|
Others
|
|
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders[1]. |
|
T77954 |
Thalidomide-5-O-C7-NH2 hydrochloride
|
|
|
|
Thalidomide-5-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment. This compound can be tethered to a protein-targeting ligand using a linker, enabling the formation of PROTA... |
|
T77917 |
Thalidomide-4-O-C7-NH2 hydrochloride
|
|
|
|
Thalidomide-4-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, plays a role in the recruitment of CRBN protein and, when linked to a protein ligand, forms PROTACs [1]. |
|
T83954 |
VH 032 amide-alkylC7-acid
|
(S,R,S)-AHPC-amido-C7-acid |
|
|
VH 032 amide-alkylC7-acid is a specialized compound designed for PROTAC research and development, serving as a functionalized von-Hippel-Lindau (VHL) protein ligand. It combines an E3 ligase ligand with an alkylC7 linker... |
|
T19663 |
Triheptanoin
|
UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011 |
Others
|
|
Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1. |
|
T50125 |
Compound C749
|
|
|
|
Compound C749 is a useful organic compound for research related to life sciences. The catalog number is T50125 and the CAS number is 57-03-4. |
|
T10727 |
Cdc7-IN-5
|
|
CDK
|
|
Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cycle. |
|
T23867 |
Cdc7-IN-7c
|
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK
|
|
Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer. |
|
T16355 |
NSC781406
|
|
PI3K
,
mTOR
|
|
NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα). |
|
T11372 |
GC7 Sulfate
|
|
Autophagy
|
|
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS act... |
|
T2274 |
SC79
|
SC 79 |
Akt
|
|
SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective ... |
|
T11828 |
LDC7559
|
|
Pyroptosis
|
|
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage. |
|
T15648 |
KDM5-C70
|
|
Histone Demethylase
|
|
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e... |
|
TP1166 |
ZINC77292789
|
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH,Fmoc-Thr(Ac₃AcNH-α-Gal)-OH |
Others
|
|
ZINC77292789 (Fmoc-Thr[GalNAc(Ac)3-α-D]-OH) is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-Thr as a Tn antigen isomer which induces the antibody production against tumor cells. ZINC7729... |
|
T3463 |
NVP-ACC789
|
ACC-789,ZK202650 |
VEGFR
,
PDGFR
|
|
ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases. |
|
T24557 |
NSC756093
|
NSC-756093,NSC 756093 |
Others
|
|
NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies. |
|
T6661 |
SC75741
|
|
Influenza Virus
,
NF-κB
|
|
SC75741 is a potent P65 inhibitor with IC50 of 200 nM |
|
T60164 |
UNC7467
|
|
Others
|
|
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol... |
|
T10729 |
Cdc7-IN-7
|
|
CDK
|
|
Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase. |
|
T10656 |
Trans-C75
|
(±)-C75 |
Others
,
Fatty Acid Synthase
|
|
trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN). |
|
T10657 |
C75
|
C-75 |
Fatty Acid Synthase
|
|
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM). |
|
T3169 |
KC7F2
|
|
HIF/HIF Prolyl-Hydroxylase
,
HIF
|
|
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity. |
|
TQ0235 |
AC710
|
|
FLT
,
PDGFR
,
c-Kit
|
|
|
|
T3084 |
SGC707
|
|
Histone Methyltransferase
|
|
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. |
|
T62921 |
EBNA1-IN-SC7
|
|
|
|
EBNA1-IN-SC7 (compound SC7) is a selective inhibitor of Epstein-Barr nuclear antigen 1 (EBNA1) that interferes with EBNA1-DNA binding activity (IC50: 23 μM). Barr virus (EBV) related cancers. |
|
T61289 |
Cdc7-IN-14
|
|
|
|
Cdc7-IN-14 (compound 82) is a highly potent inhibitor of CDC7, demonstrating an IC50 value of less than 1 nM. This compound, Cdc7-IN-14, exhibits promising potential for cancer research [1]. |
|
T36282 |
VH 032 amide-alkylC7-amine
|
VH 032 amide-alkylC7-amine |
|
|
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of funct... |
|
T61435 |
(S)-Cdc7-IN-18
|
|
|
|
(S)-Cdc7-IN-18, a potent CDC7 inhibitor, effectively impedes the overactivation of MCM2, a crucial tumor cell marker, induced by huCdc7 overexpression. Consequently, it inhibits the aberrant proliferation of tumor cells.... |
|
T61223 |
Cdc7-IN-19
|
|
|
|
Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1]. |
|
T71597 |
JCC76
|
|
|
|
JCC76 is a selective inhibitor of heat shock protein 27 (Hsp27). JCC76 inhibits the proliferation of human epidermal growth factor 2 (Her2). |
|
T61288 |
Cdc7-IN-13
|
|
|
|
Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1]. |
|
T10724 |
Cdc7-IN-1
|
|
CDK
|
|
Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and effectively induces cell death. |
|
T61436 |
Cdc7-IN-18
|
|
|
|
Cdc7-IN-18 (compound 1-2) is a highly effective inhibitor of the CDC7 enzyme. It has an IC 50 value of 1.29 nM for the Cdc7/DBF4 enzyme. In addition, this compound exhibits strong antiproliferative activities, with an IC... |
|
T60589 |
Cdc7-IN-17
|
|
|
|
Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1]. |
|
T74514 |
HD-TAC7
|
|
PROTACs
|
|
HD-TAC7, a potent PROTAC HDAC degrader, exhibits IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM for HDAC1, HDAC2, and HDAC3, respectively. It effectively decreases NF-κB p65 in RAW 264.7 macrophages and is utilized in researc... |
|
T77934 |
PhosTAC7
|
|
PROTACs
|
|
PhosTAC7, akin to PROTACs in promoting ternary complex formation, recruits a Ser/Thr phosphatase to a phosphosubstrate to facilitate dephosphorylation. |
|
T79616 |
UNC7096
|
|
Histone Methyltransferase
|
|
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1]. |
|
T60659 |
Cdc7-IN-12
|
|
|
|
Cdc7-IN-12 (compound 1) is a potent inhibitor of CDC7 (IC 50 of <1 nM) that has the potential in the cancer research. Cdc7-IN-12 exhibits antiproliferative activities in COLO205 cells with IC 50 of 100-1000 nM [1]. |
|
T16354 |
NSC745885
|
|
Others
|
|
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cel... |
|
T60815 |
Cdc7-IN-9
|
|
|
|
Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1]. |
|
T62231 |
Cdc7-IN-11
|
|
|
|
Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases. |
|
T75168 |
Homo-BacPROTAC7
|
|
|
|
Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1]. |
|
T31146 |
CycLuc7
|
CycLuc 7,CycLuc-7 |
|
|
CycLuc7 is a cyclic alkylaminoluciferin substrate for firefly luciferase. |
|
T24135 |
HEC72702
|
HEC-72702,HEC 72702 |
|
|
HEC72702 is a novel Hepatitis B virus capsid inhibitor, based on clinical candidate GLS4. HEC72702 was found to display no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at the high concentration of 10 μM. |
