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カタログ番号 | 製品名 | 別名 | ターゲット |
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T78829 | JNK2-IN-1 | JNK | |
JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and IL-6 secretion via inhibition of the NF-κB/MAPK pathway. It e... | |||
T4646 | TA-02 | p38 MAPK , Autophagy | |
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2. | |||
T2234 | TCS JNK 5a | SC202671,SC 202671,N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide,JNK Inhibitor IX,SC-202671 | Apoptosis , JNK |
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5). | |||
T3109 | SP600125 | 1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone | Apoptosis , Ferroptosis , Trk receptor , JNK , Aurora Kinase , Autophagy |
SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis. | |||
T8477 | IQ-3 | JNK | |
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... | |||
T6324 | (E/Z)-BIX02188 | 334949-59-6 | ERK , MEK , TGF-beta/Smad |
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2. | |||
T9688 | CC-90001 | JNK | |
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. | |||
T60534 | JNK-IN-11 | ||
JNK-IN-11 (compound 1) is a potent inhibitor of JNK with the potential for Alzheimer's and Parkinson's disease research. JNK-IN-11 has IC50 values of 2.2, 21.4, 1.8 μM for JNK1, JNK2, JNK3, respectively. | |||
T2675 | Bentamapimod | AS 602801 | JNK |
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK. | |||
T3598 | JNK-IN-7 | JNK inhibitor | JNK |
JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase. | |||
T1974 | PH-797804 | PH797804 | p38 MAPK , Autophagy |
PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2. | |||
T6380 | AMG 900 | AMG900,AMG-900 | p38 MAPK , Tyrosine Kinases , Aurora Kinase |
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1. | |||
T38260 | SP 600125, negative control | JNK Inhibitor II, negative control | |
SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/me... | |||
T2668 | JNK-IN-8 | JNK Inhibitor XVI | JNK , c-Kit |
JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line. | |||
T3627 | IQ-1S free acid | IQ-1,IQ-1S,IQ-1S (free acid) | NF-κB , JNK |
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can se... | |||
TP2145 | JTP10-△-R9 TFA | JNK | |
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3. | |||
TP2146 | JTP10-△-TATi TFA | JNK | |
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3. | |||
T74850 | YL5084 | ||
YL5084, a covalent inhibitor selective for JNK2 and JNK3 over JNK1, demonstrates IC50 values of 70 nM and 84 nM for JNK2 and JNK3, respectively, compared to 2173 nM for JNK1. This compound also shows antiproliferative ef... | |||
T60805 | JNK3 inhibitor-2 | ||
JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor. The IC50 values of JNK3 inhibitor-2 for JNK1, JNK2, JNK3 are >100, >100, 0.25 μM, respectively. JNK3 inhibitor-2 also inhibits DDR1 and EGFR (T790M, L858R) [1]. | |||
T14895 | Tanzisertib | CC-930 | JNK |
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. | |||
T72714 | JNK3 inhibitor-3 | JNK | |
JNK3 Inhibitor-3 (compound 15g) is a selective, blood-brain barrier permeable, and orally active inhibitor of c-Jun N-terminal kinase 3 (JNK3) with IC50 values of 147.8 nM, 44.0 nM, and 4.1 nM against JNK1, JNK2, and JNK... | |||
T63749 | JAK3-IN-13 | ||
JAK3-IN-13 is a potent, selective, orally active JAK3 inhibitor that acts on NK1 (IC50: 4728 nM), JNK2 (IC50: 2039 nM), JNK3 (IC50: 8 nM), and Tyk2 (IC50: 365 nM). JAK3-IN-13 exhibits anti-tumor effects. | |||
T2343 | AS601245 | JNK | |
AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties. | |||
T74818 | JNK3 inhibitor-8 | ||
JNK3 Inhibitor-8 is a potent, selective, and orally active inhibitor that can cross the blood-brain barrier, targeting JNK3 with IC50 values of 21 nM for JNK3, 2203 nM for JNK2, and >10000 nM for JNK1. This compound demo... | |||
T7677 | JNK Inhibitor VIII | TCS JNK 6o | JNK |
JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively). | |||
T9138 | Indirubin-3′-oxime | Indirubin-3'-monoxime | GSK-3 , CDK , JNK |
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. | |||
T8661 | AS601245.2TFA (345987-15-7 free base) | AS601245.2TFA | JNK |
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively). | |||
T79754 | JNK-IN-14 | JNK | |
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits be... | |||
T74817 | JNK3 inhibitor-7 | ||
JNK3 inhibitor-7, a potent and orally active compound that can cross the blood-brain barrier, acts as a JNK3 inhibitor with IC50 values of 53 nM for JNK3, 973 nM for JNK2, and 1039 nM for JNK1. Demonstrating significant ... | |||
T72715 | JNK3 inhibitor-4 | ||
JNK3 Inhibitor-4, a potent 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile derivative, demonstrates a strong inhibitory effect on JNK3 with an IC 50 value of 1.0 nM. It exhibits exceptional selectivity against JNK3 w... | |||
T10298L2 | AMG-548 dihydrochloride (864249-60-5 free base) | AMG-548 dihydrochloride | p38 MAPK |
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhi... | |||
T10298 | AMG-548 hydrochloride (864249-60-5 free base) | AMG-548 hydrochloride | p38 MAPK |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibi... | |||
T10298L | AMG-548 | p38 MAPK | |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole b... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN7121 | D-Epigalbacin | (-)-Zuonin A | JNK |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-04550 | JNK2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm... | |||
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... |